Elliptinium acetate, NSC-264137, HME, Celiptium, -Drug Synthesis Database

【结构式】

【药物名称】Elliptinium acetate, NSC-264137, HME, Celiptium

【化学名称】9-Hydroxy-2-methylellipticinium acetate
　　　　　　9-Hydroxy-2,5,11-trimethyl-6H-pyrido[4,3-b]carbazolium acetate

【CA登记号】58337-35-2, 58447-24-8 (iodide)

【分子式】C₂₀H₂₀N₂O₃

【分子量】336.394

【开发单位】Sanofi-synthélabo (Originator)

【药理作用】Breast Cancer Therapy, Oncolytic Drugs

合成路线1

The iodide is formed as follows: 9-Methoxy-ellipticine (I) (extracted from Ochrosia maculata) is demethylated by refluxing with pyridine hydrochloride to give 9-hydroxy-ellipticine (II), which is then treated with methyl iodide in DMF at room temperature.

参考文献中间体

【1】 Le Pecq, J.B.; et al. (ANVAR (Agence Natl. Valor. Rech.)); Derivatives of 9-hydroxy-ellipticine and a process fo their preparation. CH 616937; DE 2618223; FR 2308365; GB 1508388 .
【2】 Woodman, R.J.; NSC-264137. Drugs Fut 1979, 4, 4, 267.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	33272	9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole; 5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-yl methyl ether		C₁₈H₁₆N₂O	详情	详情
(II)	20350	5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol		C₁₇H₁₄N₂O	详情	详情

Extended Information