9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole; 5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-yl methyl ether -Drug Synthesis Database

【结构式】

【分子编号】33272

【品名】9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole; 5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-yl methyl ether

【CA登记号】

【分子式】C₁₈H₁₆N₂O

【分子量】276.33792

【元素组成】C 78.24% H 5.84% N 10.14% O 5.79%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The iodide is formed as follows: 9-Methoxy-ellipticine (I) (extracted from Ochrosia maculata) is demethylated by refluxing with pyridine hydrochloride to give 9-hydroxy-ellipticine (II), which is then treated with methyl iodide in DMF at room temperature.

参考文献中间体

合成目标

【1】 Le Pecq, J.B.; et al. (ANVAR (Agence Natl. Valor. Rech.)); Derivatives of 9-hydroxy-ellipticine and a process fo their preparation. CH 616937; DE 2618223; FR 2308365; GB 1508388 .
【2】 Woodman, R.J.; NSC-264137. Drugs Fut 1979, 4, 4, 267.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	33272	9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole; 5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-yl methyl ether		C₁₈H₁₆N₂O	详情	详情
(II)	20350	5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol		C₁₇H₁₄N₂O	详情	详情

Extended Information