|
【结 构 式】 
|
【分子编号】18762 【品名】1-Ethoxyethylene; Ethyl vinyl ether；Ethoxyethene 【CA登记号】109-92-2 |
【 分 子 式 】C4H8O 【 分 子 量 】72.10692 【元素组成】C 66.63% H 11.18% O 22.19% |
合成路线1
该中间体在本合成路线中的序号：(E)The reduction of ethylene ketal (XXI) with LiAlH4 produces the hydroxymethyl compound (XXII), which by selective tosylation with tosyl chloride yields the tosyloxymethyl compound (XXIII). The cyclization of (XXIII) with NaH in DMF affords the epoxy methane derivative (XXIV), which is deprotected by treatment with piruvic acid (D) in THF to give 2-(3-hydroxy-1-octen-1-yl)-3,5-epoxymethanocyclopentane-1-carboxaldehyde (XXV). The selective protection of the hydroxyl group of (XXV) with ethyl vinyl ether (E) affords the 1-ethoxyethoxy compound (XXVI), which is submitted to homologation in the aldehyde group by treatment with methoxymethylene-triphenylphosphorane (F) and butyllithium in THF, followed by hydrolysis of the non-isolated enol ether with mercuric acetate - water to give the acetaldehyde homolog (XXVII). The Wittig reaction of (XXVII) with 4-carboxybutyltriphenylphosphonium chloride (G) and NaH in DMSO yields 9,11-dideoxy-11alpha,9alpha-epoxymethano-15-(1-ethoxyethoxy)-PGE2 (XXVIII), which is finally deprotected by treatment with acetic acid in THF-water.
| 【1】 Trost, B.M.; et al.; An enantioconvergent approach to prostanoids. J Chem Soc Chem Commun 1978, 10, 436-438. |
| 【2】 Castaner, J.; Owen, R.T.; U-46619. Drugs Fut 1980, 5, 9, 453. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (E) | 18762 | 1-Ethoxyethylene; Ethyl vinyl ether；Ethoxyethene | 109-92-2 | C4H8O | 详情 | 详情 |
| (D) | 24066 | 2-oxopropionic acid | 127-17-3 | C3H4O3 | 详情 | 详情 |
| (F) | 39163 | (methoxymethyl)(triphenyl)phosphonium chloride | 4009-98-7 | C20H20ClOP | 详情 | 详情 |
| (G) | 39165 | (3-carboxypropyl)(triphenyl)phosphonium chloride | C22H22ClO2P | 详情 | 详情 | |
| (XXI) | 39157 | (1R,2R,3R,4S)-3-(1,3-dioxolan-2-yl)-2-[(E,3S)-3-(1-ethoxyethoxy)-1-octenyl]-4-(methoxycarbonyl)cyclopentyl [1,1'-biphenyl]-4-carboxylate | C35H46O8 | 详情 | 详情 | |
| (XXII) | 39158 | (1R,2R,3S,4S)-3-(1,3-dioxolan-2-yl)-2-[(E,3S)-3-(1-ethoxyethoxy)-1-octenyl]-4-(hydroxymethyl)cyclopentanol | C21H38O6 | 详情 | 详情 | |
| (XXIII) | 39159 | [(1S,2S,3R,4R)-2-(1,3-dioxolan-2-yl)-3-[(E,3S)-3-(1-ethoxyethoxy)-1-octenyl]-4-hydroxycyclopentyl]methyl 4-methylbenzenesulfonate | C28H44O8S | 详情 | 详情 | |
| (XXIV) | 39160 | (1S,2E)-3-[(1S,4R,5S,6R)-5-(1,3-dioxolan-2-yl)-2-oxabicyclo[2.2.1]hept-6-yl]-1-pentyl-2-propenyl 1-ethoxyethyl ether; (1S,4R,5S,6R)-5-(1,3-dioxolan-2-yl)-6-[(E,3S)-3-(1-ethoxyethoxy)-1-octenyl]-2-oxabicyclo[2.2.1]heptane | C21H36O5 | 详情 | 详情 | |
| (XXV) | 39161 | (1S,4R,5S,6R)-6-[(E,3S)-3-hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]heptane-5-carbaldehyde | C15H24O3 | 详情 | 详情 | |
| (XXVI) | 39162 | (1S,4R,5S,6R)-6-[(E,3S)-3-(1-ethoxyethoxy)-1-octenyl]-2-oxabicyclo[2.2.1]heptane-5-carbaldehyde | C19H32O4 | 详情 | 详情 | |
| (XXVII) | 39164 | 2-[(1S,4R,5S,6S)-6-[(E,3S)-3-(1-ethoxyethoxy)-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-yl]acetaldehyde | C20H34O4 | 详情 | 详情 | |
| (XXVIII) | 39166 | (Z)-7-[(1S,4R,5S,6S)-6-[(E,3S)-3-(1-ethoxyethoxy)-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-yl]-5-heptenoic acid | C25H42O5 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(VII)A new partial synthesis for taxol has been reported: The cyclization of N-(4-methoxyphenyl)benzylideneimine (I) with acetoxyacetyl chloride (II) by means of triethylamine in dichloromethane gives cis-3-acetoxy-1-(4-methoxyphenyl)-4-phenylazetidin-2-one (III), which is treated with ceric ammonium nitrate in acetonitrile to afford cis-3-acetoxy-4-phenylazetidin-2-one (IV). Hydrolysis of (IV) with KOH in THF-water yields cis-3-hydroxy-4-phenylazetidin-2-one (V), which is submitted to optical resolution giving the (3R,4S)-isomer (VI). The reaction of (VI) with ethyl vinyl ether (VII) by means of methanesulfonic acid in THF affords (3R,4S)-3-(1-ethoxyethoxy)-4-phenylazetidin-2-one (VIII), which is benzoylated with benzoyl chloride (IX) and butyllithium in hexane to give (X). Opening of the azetidine ring of (X) with KOH in THF-water gives (2R,3S)-3-(benzamido)-2-(1-ethoxyethoxy)propanoic acid (XI), which is cyclized with potassium tert-butoxide and methanesulfonyl chloride to (4S,5R)-5-(1-ethoxyethoxy)-2,4-diphenyl-5,6-dihydro-4H-1,3-oxazin-6-one (XII). Finally, this compound is condensed with 7-O-(triethylsilyl)baccatin III (XIV) [prepared from 10-deacetylbaccatin III (XIII) by successive reaction with triethylsilyl chloride and acetyl chloride] by means of dimethylaminopyridine (DMAP) in pyridine.
| 【1】 Holton, R.A. (University of Florida); Method for preparation of taxol using an oxazinone. US 5015744 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 10455 | N-(4-Methoxyphenyl)-N-[(Z)-benzylidene]amine; 4-Methoxy-N-[(Z)-benzylidene]aniline | 783-08-4 | C14H13NO | 详情 | 详情 |
| (II) | 10456 | Acetoxiacetil chloride; 2-chloro-2-oxoethyl acetate | 13831-31-7 | C4H5ClO3 | 详情 | 详情 |
| (III) | 10457 | (3R,4S)-1-(4-methoxyphenyl)-2-oxo-4-phenylazetanyl acetate | C18H17NO4 | 详情 | 详情 | |
| (IV) | 10458 | (3R,4S)-2-oxo-4-phenylazetanyl acetate | C11H11NO3 | 详情 | 详情 | |
| (V) | 63030 | cis-3-Hydroxy-4-phenyl-2-azetanone; (3R*,4S*)-3-Hydroxy-4-phenyl-2-azetanone | C9H9NO2 | 详情 | 详情 | |
| (VI) | 10459 | (3R,4S)-3-Hydroxy-4-phenyl-2-azetanone | C9H9NO2 | 详情 | 详情 | |
| (VII) | 18762 | 1-Ethoxyethylene; Ethyl vinyl ether；Ethoxyethene | 109-92-2 | C4H8O | 详情 | 详情 |
| (VIII) | 10462 | (3R,4S)-3-(1-Ethoxyethoxy)-4-phenyl-2-azetanone | C13H17NO3 | 详情 | 详情 | |
| (IX) | 10463 | Benzoyl chloride | 98-88-4 | C7H5ClO | 详情 | 详情 |
| (X) | 10464 | (3R,4S)-1-Benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetanone | C20H21NO4 | 详情 | 详情 | |
| (XI) | 10465 | (2R,3S)-3-(Benzoylamino)-2-(1-ethoxyethoxy)-3-phenylpropionic acid | C20H23NO5 | 详情 | 详情 | |
| (XII) | 10466 | (4S,5R)-5-(1-Ethoxyethoxy)-2,4-diphenyl-4,5-dihydro-6H-1,3-oxazin-6-one | C20H21NO4 | 详情 | 详情 | |
| (XIII) | 10467 | (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-(acetoxy)-1,9,12,15-tetrahydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | 32981-86-5 | C29H36O10 | 详情 | 详情 |
| (XIV) | 10468 | (1S,2S,3R,4S,7R,9R,10S,12R,15S)-4,12-bis(acetoxy)-1,15-dihydroxy-10,14,17,17-tetramethyl-11-oxo-9-[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate | C37H52O11Si | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(II)The protection of 4-bromo-2-methoxyphenol (I) with ethyl vinyl ether (II) and TsOH in dichloromethane gives the ethoxyethyl ether (III), which is treated with n-BuLi in THF to yield the phenyl lithium compound (IV). The reaction of (IV) with 2H-labeled DMF (V), followed by hydrolysis with HCl, affords the labeled 4-hydroxy-3-methoxybenzaldehyde (VI), which is finally condensed with pentane-2,4-dione (VII) by means of B2O3 and tetrahydroquinoline in DMF.
| 【1】 Threadgill, M.D.; Parveen, I.; Labelled compounds of interest as antitumour agents - VII. [H-2]- and [C-14]-curcumin. J Label Compd Radiopharm 2000, 43, 9, 883. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 45436 | 4-bromo-2-methoxyphenol | 7368-78-7 | C7H7BrO2 | 详情 | 详情 |
| (II) | 18762 | 1-Ethoxyethylene; Ethyl vinyl ether；Ethoxyethene | 109-92-2 | C4H8O | 详情 | 详情 |
| (III) | 45437 | 5-bromo-2-(1-ethoxyethoxy)phenyl methyl ether; 4-bromo-1-(1-ethoxyethoxy)-2-methoxybenzene | C11H15BrO3 | 详情 | 详情 | |
| (IV) | 45438 | [4-(1-ethoxyethoxy)-3-methoxyphenyl]lithium | C11H15LiO3 | 详情 | 详情 | |
| (V) | 33491 | Dimethylformamide | 68-12-2 | C3H7NO | 详情 | 详情 |
| (V) | 45439 | dimethylformamide | C3H7NO | 详情 | 详情 | |
| (VI) | 22701 | 4-hydroxy-3-methoxybenzaldehyde | 121-33-5 | C8H8O3 | 详情 | 详情 |
| (VI) | 45440 | 4-hydroxy-3-methoxybenzaldehyde | 21-59-0 | C8H8O3 | 详情 | 详情 |
| (VII) | 11620 | 2,4-Pentanedione;acetylacetone | 123-54-6 | C5H8O2 | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：(II)The protection of 4-bromo-2-methoxyphenol (I) with ethyl vinyl ether (II) and TsOH in dichloromethane gives the ethoxyethyl ether (III), which is treated with n-BuLi in THF to yield the phenyl lithium compound (IV). The reaction of (IV) with 14C-labeled DMF (V), followed by hydrolysis with HCl, affords the labeled 4-hydroxy-3-methoxybenzaldehyde (VI), which is finally condensed with pentane-2,4-dione (VII) by means of B2O3 and tetrahydroquinoline in DMF.
| 【1】 Threadgill, M.D.; Parveen, I.; Labelled compounds of interest as antitumour agents - VII. [H-2]- and [C-14]-curcumin. J Label Compd Radiopharm 2000, 43, 9, 883. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 45436 | 4-bromo-2-methoxyphenol | 7368-78-7 | C7H7BrO2 | 详情 | 详情 |
| (II) | 18762 | 1-Ethoxyethylene; Ethyl vinyl ether；Ethoxyethene | 109-92-2 | C4H8O | 详情 | 详情 |
| (III) | 45437 | 5-bromo-2-(1-ethoxyethoxy)phenyl methyl ether; 4-bromo-1-(1-ethoxyethoxy)-2-methoxybenzene | C11H15BrO3 | 详情 | 详情 | |
| (IV) | 45438 | [4-(1-ethoxyethoxy)-3-methoxyphenyl]lithium | C11H15LiO3 | 详情 | 详情 | |
| (V) | 33491 | Dimethylformamide | 68-12-2 | C3H7NO | 详情 | 详情 |
| (V) | 45441 | dimethylformamide | C3H7NO | 详情 | 详情 | |
| (VI) | 22701 | 4-hydroxy-3-methoxybenzaldehyde | 121-33-5 | C8H8O3 | 详情 | 详情 |
| (VI) | 45442 | 4-hydroxy-3-methoxybenzaldehyde | C8H8O3 | 详情 | 详情 | |
| (VII) | 11620 | 2,4-Pentanedione;acetylacetone | 123-54-6 | C5H8O2 | 详情 | 详情 |
合成路线5
该中间体在本合成路线中的序号：(II)The reaction of 3-methyl-2-trans-penten-4-yn-1-ol (I) with ethyl vinyl ether (II) by means of p-toluenesulfonic acid gives 1-(1-ethoxyethoxy)-3-methyl-4-trans-penten-1-yne (III), which is condensed with 2,6,6-trimethyl-3-isobutoxycyclohex-2-en-1-one (IV) by means of butyllithium in ether at -60 C to afford 5-(2,6,6-trimethyl-3-oxocyclohexen-1-yl)-3-methyl-2-trans-penten-4-yn-1-ol (V). The reduction of (V) with H2 over a Lindlar catalyst in toluene yields 5-(2,6,6-trimethyl-3-oxocyclohexen-1-yl)-3-methyl-2,4-pentadien-1-ol (VI), which is converted into the corresponding pentadienyl bromide (VII) by reaction with PBr3 in ether. The reaction of (VII) with triphenylphosphine in refluxing benzene affords 5-(2,6,6-trimethyl-3-oxocyclohexen-1-yl)-3-methyl-2,4-pentadien-1-triphenylphosphonium bromide (VIII) , which is finally condensed in a Wittig reaction with 2,7-dimethyl-2,4,6-octatriene-1,8-dial (IX) by means of sodium methoxide in dichloromethane.
| 【1】 Serradell, M.N.; Blancafort, P.; Castaner, J.; Hillier, K.; Canthazanthin. Drugs Fut 1979, 4, 7, 477. |
| 【2】 Rosenberg, M.; US 4000198 . |
| 【3】 Rigassi, N.; Schwieter, U.; DE 2037935 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 39576 | (E)-3-methyl-2-penten-4-yn-1-ol | 6153-06-6 | C6H8O | 详情 | 详情 |
| (II) | 18762 | 1-Ethoxyethylene; Ethyl vinyl ether；Ethoxyethene | 109-92-2 | C4H8O | 详情 | 详情 |
| (III) | 39577 | 5-(1-ethoxyethoxy)-3-methyl-1-penten-4-yne; 1-ethoxyethyl 3-methyl-4-penten-1-ynyl ether | C10H16O2 | 详情 | 详情 | |
| (IV) | 39578 | 3-isobutoxy-2,6,6-trimethyl-2-cyclohexen-1-one | C13H22O2 | 详情 | 详情 | |
| (V) | 39579 | 3-[(E)-5-hydroxy-3-methyl-3-penten-1-ynyl]-2,4,4-trimethyl-2-cyclohexen-1-one | C15H20O2 | 详情 | 详情 | |
| (VI) | 39580 | 3-[(1E,3E)-5-hydroxy-3-methyl-1,3-pentadienyl]-2,4,4-trimethyl-2-cyclohexen-1-one | 29538-78-1 | C15H22O2 | 详情 | 详情 |
| (VII) | 39581 | 3-[(1E,3E)-5-bromo-3-methyl-1,3-pentadienyl]-2,4,4-trimethyl-2-cyclohexen-1-one | C15H21BrO | 详情 | 详情 | |
| (VIII) | 39582 | [(2E,4E)-3-methyl-5-(2,6,6-trimethyl-3-oxo-1-cyclohexen-1-yl)-2,4-pentadienyl](triphenyl)phosphonium bromide | C33H36BrOP | 详情 | 详情 | |
| (IX) | 39583 | (2E,4E,6E)-2,7-dimethyl-2,4,6-octatrienedial | C10H12O2 | 详情 | 详情 |
合成路线6
该中间体在本合成路线中的序号：(A)A different synthetic strategy used 3,4:5,6-O-diisopropylidene-D-mannitol (VI) as the starting material. Dehydration of (VI) by means of dimethylformamide dimethylacetal and Ac2O provided olefin (VII). Selective hydrolysis of the terminal acetonide of (VII) was achieved by means of 80% AcOH to afford diol (VIII). Conversion of (VIII) to the primary tosylate (IX), followed by treatment with Na2CO3 gave epoxide (X). Oxirane ring opening in (X) with NaCN furnished the beta-hydroxy nitrile (XI). This was then protected as the unsymmetric acetal (XII) by acid-catalyzed addition of ethyl vinyl ether. Partial reduction of the nitrile function of (XII) with DIBAL in toluene at -78 C gave rise to aldehyde (XIII), which was further derivatized as the corresponding oxime (XIV). The nitrile oxide generated by treatment of oxime (XIV) with NaOCl and Et3N underwent a dipolar cycloaddition to the olefin, leading to isoxazoline (XV)
| 【1】 Takahashi, T.; Shiono, M. (Kuraray Co., Ltd.); Cyclohexanetriol derivs.. EP 0503630 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 18762 | 1-Ethoxyethylene; Ethyl vinyl ether；Ethoxyethene | 109-92-2 | C4H8O | 详情 | 详情 |
| (VI) | 59854 | C12H22O6 | 详情 | 详情 | ||
| (VII) | 59855 | C12H20O4 | 详情 | 详情 | ||
| (VIII) | 59856 | (1R)-1-[(4R,5R)-2,2-dimethyl-5-vinyl-1,3-dioxolan-4-yl]-1,2-ethanediol | C9H16O4 | 详情 | 详情 | |
| (IX) | 59857 | (2R)-2-[(4R,5R)-2,2-dimethyl-5-vinyl-1,3-dioxolan-4-yl]-2-hydroxyethyl 4-methylbenzenesulfonate | C16H22O6S | 详情 | 详情 | |
| (X) | 59858 | (4R,5R)-2,2-dimethyl-4-[(2R)oxiranyl]-5-vinyl-1,3-dioxolane | C9H14O3 | 详情 | 详情 | |
| (XI) | 59859 | (3R)-3-[(4R,5R)-2,2-dimethyl-5-vinyl-1,3-dioxolan-4-yl]-3-hydroxypropanenitrile | C10H15NO3 | 详情 | 详情 | |
| (XII) | 59860 | (3R)-3-[(4R,5R)-2,2-dimethyl-5-vinyl-1,3-dioxolan-4-yl]-3-(1-ethoxyethoxy)propanenitrile | C14H23NO4 | 详情 | 详情 | |
| (XIII) | 59861 | (3R)-3-[(4R,5R)-2,2-dimethyl-5-vinyl-1,3-dioxolan-4-yl]-3-(1-ethoxyethoxy)propanal | C14H24O5 | 详情 | 详情 | |
| (XIV) | 59862 | (3R)-3-[(4R,5R)-2,2-dimethyl-5-vinyl-1,3-dioxolan-4-yl]-3-(1-ethoxyethoxy)propanal oxime | C14H25NO5 | 详情 | 详情 | |
| (XV) | 59863 | (3aR,4R,8bR)-2,2-dimethyl-3a,4,5,8,8a,8b-hexahydro[1,3]dioxolo[4,5-e][2,1]benzisoxazol-4-yl 1-ethoxyethyl ether; (3aR,4R,8bR)-4-(1-ethoxyethoxy)-2,2-dimethyl-3a,4,5,8,8a,8b-hexahydro[1,3]dioxolo[4,5-e][2,1]benzisoxazole | C14H23NO5 | 详情 | 详情 |
合成路线7
该中间体在本合成路线中的序号：(II)Tetrofosmin (III) was prepared by condensation of 1,2-diphosphinoethane (I) with ethyl vinyl ether (II) in the presence of AIBN. The title technetium complex was then prepared by treatment of a solution of sodium pertechnetate with a reducing agent in the presence of the bis-phosphine ligand (III).
| 【1】 Archer, C.M.; Dilworth, J.R.; Jobanputra, P.; Latham, I.A.; Thompson, R.M. (Amersham plc); New cores for technetium radiopharmaceuticals. JP 2002060397; WO 9103262 . |
| 【2】 Kelly, J.D.; Chiu, K.W.; Latham, I.A. (Amersham plc); Ligands and cationic complexes thereof with technetium-99m. EP 0337654; JP 1997328495 . |
| 【3】 Kelly, J.D.; et al.; Technetium-99m-tetrofosmin as a new radiopharmaceutical for myocardial perfusion imaging. J Nucl Med 1993, 34, 2, 222. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 56546 | 1,2-Bis(phosphino)ethane | 5518-62-7 | C2H8P2 | 详情 | 详情 |
| (II) | 18762 | 1-Ethoxyethylene; Ethyl vinyl ether；Ethoxyethene | 109-92-2 | C4H8O | 详情 | 详情 |
| (III) | 56547 | 2-[{2-[bis(2-ethoxyethyl)phosphino]ethyl}(2-ethoxyethyl)phosphino]ethyl ethyl ether; 6,9-bis(2-ethoxyethyl)-3,12-dioxa-6,9-diphosphatetradecane | C18H40O4P2 | 详情 | 详情 |
合成路线8
该中间体在本合成路线中的序号：Synthesis of intermediate (XIV): The condensation of epoxide (VIII) with isopropenyl bromide (IX) by means of n-BuLi and CuCN gives the alcohol (X), which is treated with 2-(tert-butoxycarbonyloxyimino)-2-phenylacetonitrile (Boc-ON) and n-BuLi in toluene to yield the cyclic carbonate (XI). The epoxidation of (XI) with HOAc in THF affords the epoxide (XII), which is selectively monoprotected with ethyl vinyl ether to provide the secondary alcohol (XIII). Finally this compound is silylated with TBDMSCl and imidazole to furnish the desired intermediate (XIV).
| 【1】 Guo, J.; et al.; Total synthesis of altohyrtin A (spongistatin 1): Part 1. Angew Chem. Int Ed Engl 1998, 37, 1-2, 187. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 18762 | 1-Ethoxyethylene; Ethyl vinyl ether；Ethoxyethene | 109-92-2 | C4H8O | 详情 | 详情 | |
| (VIII) | 42374 | tert-butyl(dimethyl)[(2R)oxiranylmethoxy]silane; tert-butyl(dimethyl)silyl (2R)oxiranylmethyl ether | C9H20O2Si | 详情 | 详情 | |
| (IX) | 42375 | 2-bromo-1-propene；2-bromopropene;Isopropenyl bromide;a-Methylvinyl bromide | 557-93-7 | C3H5Br | 详情 | 详情 |
| (X) | 42376 | (2R)-1-[[tert-butyl(dimethyl)silyl]oxy]-4-methyl-4-penten-2-ol | C12H26O2Si | 详情 | 详情 | |
| (XI) | 42377 | (4S,6R)-6-([[tert-butyl(dimethyl)silyl]oxy]methyl)-4-(iodomethyl)-4-methyl-1,3-dioxan-2-one | C13H25IO4Si | 详情 | 详情 | |
| (XII) | 42378 | (2R)-3-[(2S)-2-methyloxiranyl]-1,2-propanediol | C6H12O3 | 详情 | 详情 | |
| (XIII) | 42379 | (2R)-1-(2-ethoxyethoxy)-3-[(2S)-2-methyloxiranyl]-2-propanol | C10H20O4 | 详情 | 详情 | |
| (XIV) | 42380 | tert-butyl(dimethyl)silyl (1R)-2-(2-ethoxyethoxy)-1-[[(2S)-2-methyloxiranyl]methyl]ethyl ether; (5R)-2,2,3,3-tetramethyl-5-[[(2S)-2-methyloxiranyl]methyl]-4,7,10-trioxa-3-siladodecane | C16H34O4Si | 详情 | 详情 |
合成路线9
该中间体在本合成路线中的序号：The reaction of oxirane (I) with vinylmagnesium bromide in THF gives 1-(4-fluorophenoxy)-4-penten-2(S)-ol (II), which is treated with ethyl vinyl ether and mercuric trifluoroacetate to yield the vinyl ether (III). The cyclization of (III) by means of Grubb's catalyst in refluxing benzene affords the dihydrofuran (IV), which is treated with benzenesulfinic acid in dichloromethane to give the sulfone (V). The reaction of (V) with the acetylenic tetrahydropyranyl ether (VI) by means of isopropylmagnesium bromide in THF yields the expected addition product (VII), which is treated with TsOH to eliminate the tetrahydropyranyl group and provide the alcohol (VIII). The condensation of (VIII) with N,O-bis (phenoxycarbonyl)hydroxylamine (IX) by means of PPh3 and DEAD in THF affords the protected carbamate derivative (X), which is finally treated with ammonia in methanol.
| 【1】 Gurjar, M.K.; et al.; A versatile approach to anti-asthmatic compound CMI-977 and its six-membered analogue. Synthesis 2000, 4, 557. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 16524 | bromo(vinyl)magnesium | 1826-67-1 | C2H3BrMg | 详情 | 详情 | |
| 18762 | 1-Ethoxyethylene; Ethyl vinyl ether；Ethoxyethene | 109-92-2 | C4H8O | 详情 | 详情 | |
| 40726 | dioxo(phenyl)-lambda(6)-sulfane | C6H6O2S | 详情 | 详情 | ||
| (I) | 32986 | 4-fluorophenyl (2S)oxiranylmethyl ether; (2S)-2-[(4-fluorophenoxy)methyl]oxirane | 108648-25-5 | C9H9FO2 | 详情 | 详情 |
| (II) | 38536 | (2S)-1-(4-fluorophenoxy)-4-penten-2-ol | C11H13FO2 | 详情 | 详情 | |
| (III) | 38537 | (1S)-1-[(4-fluorophenoxy)methyl]-3-butenyl vinyl ether; 1-fluoro-4-[[(2S)-2-(vinyloxy)-4-pentenyl]oxy]benzene | C13H15FO2 | 详情 | 详情 | |
| (IV) | 38538 | (2S)-2-[(4-fluorophenoxy)methyl]-2,3-dihydrofuran; (2S)-2,3-dihydro-2-furanylmethyl 4-fluorophenyl ether | C11H11FO2 | 详情 | 详情 | |
| (V) | 38539 | (2S,5R)-2-[(4-fluorophenoxy)methyl]-5-(phenylsulfonyl)tetrahydrofuran; (2R,5S)-5-[(4-fluorophenoxy)methyl]tetrahydro-2-furanyl phenyl sulfone | C17H17FO4S | 详情 | 详情 | |
| (VI) | 38540 | 2-(4-pentynyloxy)tetrahydro-2H-pyran; 4-pentynyl tetrahydro-2H-pyran-2-yl ether | 62992-46-5 | C10H16O2 | 详情 | 详情 |
| (VII) | 38541 | 5-[(2S,5S)-5-[(4-fluorophenoxy)methyl]tetrahydro-2-furanyl]-4-pentynyl tetrahydro-2H-pyran-2-yl ether; 2-[(5-[(2S,5S)-5-[(4-fluorophenoxy)methyl]tetrahydro-2-furanyl]-4-pentynyl)oxy]tetrahydro-2H-pyran | C21H27FO4 | 详情 | 详情 | |
| (VIII) | 19645 | 4-[(2S,5S)-5-[(4-fluorophenoxy)methyl]tetrahydro-2-furanyl]-3-butyn-1-ol | C15H17FO3 | 详情 | 详情 | |
| (IX) | 19646 | 1-[([[(phenoxycarbonyl)oxy]amino]carbonyl)oxy]benzene | C14H11NO5 | 详情 | 详情 | |
| (X) | 19647 | (2S,5S)-2-[(4-fluorophenoxy)methyl]-5-(4-[(phenoxycarbonyl)[(phenoxycarbonyl)oxy]amino]-1-butynyl)tetrahydrofuran | C29H26FNO7 | 详情 | 详情 |
合成路线10
该中间体在本合成路线中的序号：(VIII)1) The reaction of 3-(2,5,5-trimethyl-1,3-dioxan-2-yl)thiophene (I) with butyllithium, SO2 and hydroxylamine-O-sulfonic acid in hexane/THF gives the corresponding sulfonamide (II), which is hydrolyzed with HCl yielding 3-acetylthiophene-2-sulfonamide (III). The cyclization of (III) with pyridinium bromide perbromide (IV) and NaBH4 affords 4-hydroxy-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine 1,1-dioxide (V), which is treated with 1,3-dibromopropane (VI) and NaH in DMF giving the corresponding 3-bromopropyl derivative (VII). The protection of the hydroxy group of (VII) with ethyl vinyl ether (VIII) in p-toluenesulfonic acid yields the ethoxyethyl ether (IX), which by reaction with sodium methoxide in refluxing methanol affords the 3-methoxypropyl derivative (X). The sulfonation of (X) with butyllithium, SO2 and hydroxylamine-O-sulfonic acid in hexane/THF gives the sulfonamide (XI), which is oxidized with CrO3/H2SO4 to yield 2-(3-methoxypropyl)-4-oxo-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide (XII). The stereocontrolled reduction of (XII) with (+)-beta-chlorodiisopinocamphenylborane [(+)-CDPB] in THF affords the 4(S)-hydroxy derivative (XIII), which is finally treated first with p-toluenesulfonyl chloride/triethylamine and then with ethylamine in THF.
| 【1】 Graul, A.; Wroblewski, T.; Castañer, J.; Brinzolamide. Drugs Fut 1998, 23, 4, 365. |
| 【2】 Dean, T.R.; Chen, H.-H.; May, J.A. (Alcon Laboratories, Inc.); Thiophene sulfonamides useful as carbonic anhydrase inhibitors. EP 0527801; JP 1993508832; US 5153192; US 5240923; WO 9115486 . |
| 【3】 Dean, T.R.; Chen, H.-H.; May, J.A. (Alcon Laboratories, Inc.); Sulfonamides useful as carbonic anhydrase inhibitors. US 5378703 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 17300 | 2,5,5-trimethyl-2-(3-thienyl)-1,3-dioxane | C11H16O2S | 详情 | 详情 | |
| (II) | 17301 | 3-(2,5,5-trimethyl-1,3-dioxan-2-yl)-2-thiophenesulfonamide | 138890-87-6 | C11H17NO4S2 | 详情 | 详情 |
| (III) | 17302 | 3-acetyl-2-thiophenesulfonamide | C6H7NO3S2 | 详情 | 详情 | |
| (IV) | 17303 | pyridinium | C5H6N | 详情 | 详情 | |
| (V) | 17304 | 4-hydroxy-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-1,1(2H)-dione | 138890-97-8 | C6H7NO3S2 | 详情 | 详情 |
| (VI) | 12581 | 1,3-Dibromopropane | 109-64-8 | C3H6Br2 | 详情 | 详情 |
| (VII) | 17306 | 2-(3-bromopropyl)-4-hydroxy-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-1,1(2H)-dione; (±)-2-(3-bromopropyl)-3,4-dihydro-4-hydroxy-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide | 154127-37-4 | C9H12BrNO3S2 | 详情 | 详情 |
| (VIII) | 18762 | 1-Ethoxyethylene; Ethyl vinyl ether；Ethoxyethene | 109-92-2 | C4H8O | 详情 | 详情 |
| (IX) | 17308 | 2-(3-bromopropyl)-4-(1-ethoxyethoxy)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-1,1(2H)-dione | C13H20BrNO4S2 | 详情 | 详情 | |
| (X) | 17309 | 4-(1-ethoxyethoxy)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-1,1(2H)-dione | 165116-92-7 | C14H23NO5S2 | 详情 | 详情 |
| (XI) | 17310 | 4-hydroxy-2-(3-methoxypropyl)-1,1-dioxo-1,2,3,4-tetrahydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide | 154127-41-0 | C10H16N2O6S3 | 详情 | 详情 |
| (XII) | 17311 | 2-(3-methoxypropyl)-1,1,4-trioxo-1,2,3,4-tetrahydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide | C10H14N2O6S3 | 详情 | 详情 | |
| (XIII) | 17312 | (4S)-4-hydroxy-2-(3-methoxypropyl)-1,1-dioxo-1,2,3,4-tetrahydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide | 154127-42-1 | C10H16N2O6S3 | 详情 | 详情 |
合成路线11
该中间体在本合成路线中的序号：(VI)Reduction of (-)-R-carvone (I) with LiAlH4 in Et2O at -78 C gave alcohol (II). Inversion of the hydroxyl group was then achieved by Mitsunobu reaction with 4-nitrobenzoic acid (III), followed by hydrolysis of the resulting 4-nitrobenzoate ester (IV) to give (V). Treatment of alcohol (V) with ethyl vinyl ether (VI) and N-bromosuccinimide produced the bromoacetal (VII). Subsequent intermolecular radical cyclization of (VII) with NaBH4 in the presence of a catalytic amount of Bu3SnCl and AIBN yielded cyclic acetal (VIII). Acidic hydrolysis of (VIII) followed by reduction of the resulting aldehyde (IX) with LiAlH4 provided diol (X). Protection of the primary alcohol group with trityl chloride in the presence of DMAP gave (XI), and subsequent oxidation of the secondary alcohol with pyridinum chlorochromate afforded ketone (XII). Further carbomethoxylation of (XII) by treatment with LDA and methyl cyanoformate yielded ketoester (XIII), which was reduced to alcohol (XIV) with NaBH4 in MeOH at 0 C. Then, alcohol (XIV) was converted to methyl ether (XV) by reaction with methyl iodide and NaH in DMF, and the ester group was reduced to alcohol (XVI) with LiAlH4 in Et2O at 0 C. Alcohol (XVI) was converted to mesylate (XVII) with methanesulfonyl chloride and Et3N.
| 【1】 Tsukuda, T.; Watanabe, M.; Ontsuka, H.; Hattori, K.; Shirai, M.; Shimma, N.; Synthesis of novel antifungal agents (2). Bioorg Med Chem Lett 1998, 8, 14, 1825. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 13386 | (5R)-5-Isopropenyl-2-methyl-2-cyclohexen-1-one; L-(-)-Carvone | 6485-40-1 | C10H14O | 详情 | 详情 |
| (II) | 18758 | (1R,5R)-5-isopropenyl-2-methyl-2-cyclohexen-1-ol | C10H16O | 详情 | 详情 | |
| (III) | 18119 | 4-nitrobenzoic acid; p-nitrobenzoic acid | 62-23-7 | C7H5NO4 | 详情 | 详情 |
| (IV) | 18760 | (1S,5R)-5-isopropenyl-2-methyl-2-cyclohexen-1-yl 4-nitrobenzoate | C17H19NO4 | 详情 | 详情 | |
| (V) | 18761 | (1S,5R)-5-isopropenyl-2-methyl-2-cyclohexen-1-ol | C10H16O | 详情 | 详情 | |
| (VI) | 18762 | 1-Ethoxyethylene; Ethyl vinyl ether；Ethoxyethene | 109-92-2 | C4H8O | 详情 | 详情 |
| (VII) | 18763 | 2-bromo-1-ethoxyethyl (1S,5R)-5-isopropenyl-2-methyl-2-cyclohexen-1-yl ether; (4R,6S)-6-(2-bromo-1-ethoxyethoxy)-4-isopropenyl-1-methyl-1-cyclohexene | C14H23BrO2 | 详情 | 详情 | |
| (VIII) | 18764 | (3aS,6R,7aS)-2-ethoxy-6-isopropenyl-3a-methyloctahydro-1-benzofuran; (3aS,6R,7aS)-6-isopropenyl-3a-methyloctahydro-1-benzofuran-2-yl ethyl ether | C14H24O2 | 详情 | 详情 | |
| (IX) | 18765 | 2-[(1S,2S,4R)-2-hydroxy-4-isopropenyl-1-methylcyclohexyl]acetaldehyde | C12H20O2 | 详情 | 详情 | |
| (X) | 18766 | (1S,2S,5R)-2-(2-hydroxyethyl)-5-isopropenyl-2-methylcyclohexanol | C12H22O2 | 详情 | 详情 | |
| (XI) | 18767 | (1S,2S,5R)-5-isopropenyl-2-methyl-2-[2-(trityloxy)ethyl]cyclohexanol | C31H36O2 | 详情 | 详情 | |
| (XII) | 18768 | (2S,5R)-5-isopropenyl-2-methyl-2-[2-(trityloxy)ethyl]cyclohexanone | C31H34O2 | 详情 | 详情 | |
| (XIII) | 18769 | methyl (3S,6R)-6-isopropenyl-3-methyl-2-oxo-3-[2-(trityloxy)ethyl]cyclohexanecarboxylate | C33H36O4 | 详情 | 详情 | |
| (XIV) | 18770 | methyl (1S,2R,3S,6R)-2-hydroxy-6-isopropenyl-3-methyl-3-[2-(trityloxy)ethyl]cyclohexanecarboxylate | C33H38O4 | 详情 | 详情 | |
| (XV) | 18771 | methyl (1S,2R,3S,6R)-6-isopropenyl-2-methoxy-3-methyl-3-[2-(trityloxy)ethyl]cyclohexanecarboxylate | C34H40O4 | 详情 | 详情 | |
| (XVI) | 18772 | [(1R,2R,3S,6R)-6-isopropenyl-2-methoxy-3-methyl-3-[2-(trityloxy)ethyl]cyclohexyl]methanol | C33H40O3 | 详情 | 详情 | |
| (XVII) | 18773 | [(1R,2R,3S,6R)-6-isopropenyl-2-methoxy-3-methyl-3-[2-(trityloxy)ethyl]cyclohexyl]methyl methanesulfonate | C34H42O5S | 详情 | 详情 |
合成路线12
该中间体在本合成路线中的序号：(XVII)Reaction of mesylate (XVII) with triazole sodium salt (XVIII) gave (XIX). Ozonization of olefinic double bond, followed by treatment with Me2S and K2CO3 provided ketone (XX). Then, haloform reaction with NaOBr gave acid (XXI), and reduction with LiAlH4 in cold Et2O afforded primary alcohol (XXII). Alcohol (XXII) was converted to mesylate (XXIII), and this was condensed with 4-(trifluoromethoxy)phenol (XXIV) to give ether (XXV). Deprotection of the trityl group with formic acid in EtOAc and subsequent reaction with methanesulfonyl chloride provided mesylate (XXVI), which was finally condensed with mercaptoimidazole (XXVII) to furnish the target compound.
| 【1】 Tsukuda, T.; Watanabe, M.; Ontsuka, H.; Hattori, K.; Shirai, M.; Shimma, N.; Synthesis of novel antifungal agents (2). Bioorg Med Chem Lett 1998, 8, 14, 1825. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XVII) | 18762 | 1-Ethoxyethylene; Ethyl vinyl ether；Ethoxyethene | 109-92-2 | C4H8O | 详情 | 详情 |
| (XVIII) | 16341 | 1H-1,2,4-triazol-1-ylsodium | C2H2N3Na | 详情 | 详情 | |
| (XIX) | 18775 | 2-[(1S,2R,3R,4R)-4-isopropenyl-2-methoxy-1-methyl-3-(1H-1,2,4-triazol-1-ylmethyl)cyclohexyl]ethyl trityl ether; 1-([(1R,2R,3S,6R)-6-isopropenyl-2-methoxy-3-methyl-3-[2-(trityloxy)ethyl]cyclohexyl]methyl)-1H-1,2,4-triazole | C35H41N3O2 | 详情 | 详情 | |
| (XX) | 18776 | 1-[(1R,2R,3R,4S)-3-methoxy-4-methyl-2-(1H-1,2,4-triazol-1-ylmethyl)-4-[2-(trityloxy)ethyl]cyclohexyl]-1-ethanone | C34H39N3O3 | 详情 | 详情 | |
| (XXI) | 18777 | (1R,2R,3R,4S)-3-methoxy-4-methyl-2-(1H-1,2,4-triazol-1-ylmethyl)-4-[2-(trityloxy)ethyl]cyclohexanecarboxylic acid | C33H37N3O4 | 详情 | 详情 | |
| (XXII) | 18778 | [(1R,2R,3R,4S)-3-methoxy-4-methyl-2-(1H-1,2,4-triazol-1-ylmethyl)-4-[2-(trityloxy)ethyl]cyclohexyl]methanol | C33H39N3O3 | 详情 | 详情 | |
| (XXIII) | 18779 | [(1R,2R,3R,4S)-3-methoxy-4-methyl-2-(1H-1,2,4-triazol-1-ylmethyl)-4-[2-(trityloxy)ethyl]cyclohexyl]methyl methanesulfonate | C34H41N3O5S | 详情 | 详情 | |
| (XXIV) | 18780 | 4-(trifluoromethoxy)phenol | 828-27-3 | C7H5F3O2 | 详情 | 详情 |
| (XXV) | 18781 | 1-([(1R,2R,3S,6R)-2-methoxy-3-methyl-6-[[4-(trifluoromethoxy)phenoxy]methyl]-3-[2-(trityloxy)ethyl]cyclohexyl]methyl)-1H-1,2,4-triazole; 2-((1S,2R,3R,4R)-2-methoxy-1-methyl-3-(1H-1,2,4-triazol-1-ylmethyl)-4-[[4-(trifluoromethoxy)phenoxy]methyl]cyclohexyl)ethyl trityl ether | C40H42F3N3O4 | 详情 | 详情 | |
| (XXVI) | 18782 | 2-((1S,2R,3R,4R)-2-methoxy-1-methyl-3-(1H-1,2,4-triazol-1-ylmethyl)-4-[[4-(trifluoromethoxy)phenoxy]methyl]cyclohexyl)ethyl methanesulfonate | C22H30F3N3O6S | 详情 | 详情 | |
| (XXVII) | 18783 | 1-methyl-1H-imidazol-2-ylhydrosulfide; 1-methyl-1H-imidazole-2-thiol | 60-56-0 | C4H6N2S | 详情 | 详情 |
合成路线13
该中间体在本合成路线中的序号：(VI)Reduction of (-)-R-carvone (I) with LiAlH4 in Et2O at -78 C gave alcohol (II). Inversion of the hydroxyl group was then achieved by Mitsunobu reaction with 4-nitrobenzoic acid (III), followed by hydrolysis of the resulting 4-nitrobenzoate ester (IV) to give (V). Treatment of alcohol (V) with ethyl vinyl ether (VI) and N-bromosuccinimide produced the bromoacetal (VII). Subsequent intermolecular radical cyclization of (VII) with NaBH4 in the presence of a catalytic amount of Bu3SnCl and AIBN yielded cyclic acetal (VIII). Acidic hydrolysis of (VIII) followed by reduction of the resulting aldehyde (IX) with LiAlH4 provided diol (X). Protection of the primary alcohol group with trityl chloride in the presence of DMAP gave (XI), and subsequent oxidation of the secondary alcohol with pyridinum chlorochromate afforded ketone (XII). Further carbomethoxylation of (XII) by treatment with LDA and methyl cyanoformate yielded ketoester (XIII), which was reduced to alcohol (XIV) with NaBH4 in MeOH at 0 C. Then, alcohol (XIV) was converted to methyl ether (XV) by reaction with methyl iodide and NaH in DMF, and the ester group was reduced to alcohol (XVI) with LiAlH4 in Et2O at 0 C. Alcohol (XVI) was converted to mesylate (XVII) with methanesulfonyl chloride and Et3N.
| 【1】 Tsukuda, T.; Watanabe, M.; Ontsuka, H.; Hattori, K.; Shirai, M.; Shimma, N.; Synthesis of novel antifungal agents (2). Bioorg Med Chem Lett 1998, 8, 14, 1825. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 13386 | (5R)-5-Isopropenyl-2-methyl-2-cyclohexen-1-one; L-(-)-Carvone | 6485-40-1 | C10H14O | 详情 | 详情 |
| (II) | 18758 | (1R,5R)-5-isopropenyl-2-methyl-2-cyclohexen-1-ol | C10H16O | 详情 | 详情 | |
| (III) | 18119 | 4-nitrobenzoic acid; p-nitrobenzoic acid | 62-23-7 | C7H5NO4 | 详情 | 详情 |
| (IV) | 18760 | (1S,5R)-5-isopropenyl-2-methyl-2-cyclohexen-1-yl 4-nitrobenzoate | C17H19NO4 | 详情 | 详情 | |
| (V) | 18761 | (1S,5R)-5-isopropenyl-2-methyl-2-cyclohexen-1-ol | C10H16O | 详情 | 详情 | |
| (VI) | 18762 | 1-Ethoxyethylene; Ethyl vinyl ether；Ethoxyethene | 109-92-2 | C4H8O | 详情 | 详情 |
| (VII) | 18763 | 2-bromo-1-ethoxyethyl (1S,5R)-5-isopropenyl-2-methyl-2-cyclohexen-1-yl ether; (4R,6S)-6-(2-bromo-1-ethoxyethoxy)-4-isopropenyl-1-methyl-1-cyclohexene | C14H23BrO2 | 详情 | 详情 | |
| (VIII) | 18764 | (3aS,6R,7aS)-2-ethoxy-6-isopropenyl-3a-methyloctahydro-1-benzofuran; (3aS,6R,7aS)-6-isopropenyl-3a-methyloctahydro-1-benzofuran-2-yl ethyl ether | C14H24O2 | 详情 | 详情 | |
| (IX) | 18765 | 2-[(1S,2S,4R)-2-hydroxy-4-isopropenyl-1-methylcyclohexyl]acetaldehyde | C12H20O2 | 详情 | 详情 | |
| (X) | 18766 | (1S,2S,5R)-2-(2-hydroxyethyl)-5-isopropenyl-2-methylcyclohexanol | C12H22O2 | 详情 | 详情 | |
| (XI) | 18767 | (1S,2S,5R)-5-isopropenyl-2-methyl-2-[2-(trityloxy)ethyl]cyclohexanol | C31H36O2 | 详情 | 详情 | |
| (XII) | 18768 | (2S,5R)-5-isopropenyl-2-methyl-2-[2-(trityloxy)ethyl]cyclohexanone | C31H34O2 | 详情 | 详情 | |
| (XIII) | 18769 | methyl (3S,6R)-6-isopropenyl-3-methyl-2-oxo-3-[2-(trityloxy)ethyl]cyclohexanecarboxylate | C33H36O4 | 详情 | 详情 | |
| (XIV) | 18770 | methyl (1S,2R,3S,6R)-2-hydroxy-6-isopropenyl-3-methyl-3-[2-(trityloxy)ethyl]cyclohexanecarboxylate | C33H38O4 | 详情 | 详情 | |
| (XV) | 18771 | methyl (1S,2R,3S,6R)-6-isopropenyl-2-methoxy-3-methyl-3-[2-(trityloxy)ethyl]cyclohexanecarboxylate | C34H40O4 | 详情 | 详情 | |
| (XVI) | 18772 | [(1R,2R,3S,6R)-6-isopropenyl-2-methoxy-3-methyl-3-[2-(trityloxy)ethyl]cyclohexyl]methanol | C33H40O3 | 详情 | 详情 | |
| (XVII) | 18773 | [(1R,2R,3S,6R)-6-isopropenyl-2-methoxy-3-methyl-3-[2-(trityloxy)ethyl]cyclohexyl]methyl methanesulfonate | C34H42O5S | 详情 | 详情 |
合成路线14
该中间体在本合成路线中的序号：(XVII)Reaction of mesylate (XVII) with triazole sodium salt (XVIII) gave (XIX). Ozonization of olefinic double bond, followed by treatment with Me2S and K2CO3 provided ketone (XX). Then, haloform reaction with NaOBr gave acid (XXI), and reduction with LiAlH4 in cold Et2O afforded primary alcohol (XXII). Alcohol (XXII) was converted to mesylate (XXIII), and this was condensed with 4-(trifluoromethoxy)phenol (XXIV) to give ether (XXV). Deprotection of the trityl group with formic acid in EtOAc and subsequent reaction with methanesulfonyl chloride provided mesylate (XXVI), which was finally condensed with morpholine (XXVII) to furnish the target compound.
| 【1】 Tsukuda, T.; Watanabe, M.; Ontsuka, H.; Hattori, K.; Shirai, M.; Shimma, N.; Synthesis of novel antifungal agents (2). Bioorg Med Chem Lett 1998, 8, 14, 1825. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XVII) | 18762 | 1-Ethoxyethylene; Ethyl vinyl ether；Ethoxyethene | 109-92-2 | C4H8O | 详情 | 详情 |
| (XVIII) | 16341 | 1H-1,2,4-triazol-1-ylsodium | C2H2N3Na | 详情 | 详情 | |
| (XIX) | 18775 | 2-[(1S,2R,3R,4R)-4-isopropenyl-2-methoxy-1-methyl-3-(1H-1,2,4-triazol-1-ylmethyl)cyclohexyl]ethyl trityl ether; 1-([(1R,2R,3S,6R)-6-isopropenyl-2-methoxy-3-methyl-3-[2-(trityloxy)ethyl]cyclohexyl]methyl)-1H-1,2,4-triazole | C35H41N3O2 | 详情 | 详情 | |
| (XX) | 18776 | 1-[(1R,2R,3R,4S)-3-methoxy-4-methyl-2-(1H-1,2,4-triazol-1-ylmethyl)-4-[2-(trityloxy)ethyl]cyclohexyl]-1-ethanone | C34H39N3O3 | 详情 | 详情 | |
| (XXI) | 18777 | (1R,2R,3R,4S)-3-methoxy-4-methyl-2-(1H-1,2,4-triazol-1-ylmethyl)-4-[2-(trityloxy)ethyl]cyclohexanecarboxylic acid | C33H37N3O4 | 详情 | 详情 | |
| (XXII) | 18778 | [(1R,2R,3R,4S)-3-methoxy-4-methyl-2-(1H-1,2,4-triazol-1-ylmethyl)-4-[2-(trityloxy)ethyl]cyclohexyl]methanol | C33H39N3O3 | 详情 | 详情 | |
| (XXIII) | 18779 | [(1R,2R,3R,4S)-3-methoxy-4-methyl-2-(1H-1,2,4-triazol-1-ylmethyl)-4-[2-(trityloxy)ethyl]cyclohexyl]methyl methanesulfonate | C34H41N3O5S | 详情 | 详情 | |
| (XXIV) | 18780 | 4-(trifluoromethoxy)phenol | 828-27-3 | C7H5F3O2 | 详情 | 详情 |
| (XXV) | 18781 | 1-([(1R,2R,3S,6R)-2-methoxy-3-methyl-6-[[4-(trifluoromethoxy)phenoxy]methyl]-3-[2-(trityloxy)ethyl]cyclohexyl]methyl)-1H-1,2,4-triazole; 2-((1S,2R,3R,4R)-2-methoxy-1-methyl-3-(1H-1,2,4-triazol-1-ylmethyl)-4-[[4-(trifluoromethoxy)phenoxy]methyl]cyclohexyl)ethyl trityl ether | C40H42F3N3O4 | 详情 | 详情 | |
| (XXVI) | 18782 | 2-((1S,2R,3R,4R)-2-methoxy-1-methyl-3-(1H-1,2,4-triazol-1-ylmethyl)-4-[[4-(trifluoromethoxy)phenoxy]methyl]cyclohexyl)ethyl methanesulfonate | C22H30F3N3O6S | 详情 | 详情 | |
| (XXVII) | 10388 | Morpholine | 110-91-8 | C4H9NO | 详情 | 详情 |
合成路线15
该中间体在本合成路线中的序号：(V)Treatment of hydroxylactone (I) with benzyl bromide and silver oxide gave the corresponding benzyl ether (II). Subsequent reduction of the lactone (II) with LiAlH4 afforded the linear diol (III). Tioether (IV) was prepared by treatment of (III) with diphenyl disulfide and tributylphosphine, and the remaining hydroxyl group of (IV) was then protected as the ketal (VI) using ethyl vinyl ether (V) and pyridinium tosylate. Oxidation of (VI) to sulfone (VII) was accomplished with m-chloroperbenzoic acid. Condensation of (VII) with 2-methyl-delta-valerolactone (VIII), followed by BF3 - Et2O-catalyzed cyclization furnished spiroketal (IX). Finally, the phenylsulfonyl group of (IX) was reductively removed by means of sodium amalgam.
| 【1】 Oikawa, H.; et al.; Highly regio- and stereoselective reductions of spiroketals. Tetrahedron Lett 1993, 34, 33, 5303. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 12912 | 1-(Bromomethyl)benzene; Alpha-bromotoluene | 100-39-0 | C7H7Br | 详情 | 详情 | |
| (I) | 35134 | (4S,5S)-5-(hydroxymethyl)-4-methyldihydro-2(3H)-furanone | C6H10O3 | 详情 | 详情 | |
| (II) | 35135 | (4S,5S)-5-[(benzyloxy)methyl]-4-methyldihydro-2(3H)-furanone | C13H16O3 | 详情 | 详情 | |
| (III) | 35136 | (3S,4S)-5-(benzyloxy)-3-methyl-1,4-pentanediol | C13H20O3 | 详情 | 详情 | |
| (IV) | 35137 | (2S,3S)-1-(benzyloxy)-3-methyl-5-(phenylsulfanyl)-2-pentanol | C19H24O2S | 详情 | 详情 | |
| (V) | 18762 | 1-Ethoxyethylene; Ethyl vinyl ether；Ethoxyethene | 109-92-2 | C4H8O | 详情 | 详情 |
| (VI) | 35138 | benzyl (2S,3S)-2-(1-ethoxyethoxy)-3-methyl-5-(phenylsulfanyl)pentyl ether; 1-([[(2S,3S)-2-(1-ethoxyethoxy)-3-methyl-5-(phenylsulfanyl)pentyl]oxy]methyl)benzene | C23H32O3S | 详情 | 详情 | |
| (VII) | 35139 | (3S,4S)-5-(benzyloxy)-4-(1-ethoxyethoxy)-3-methylpentyl phenyl sulfone; [(3S,4S)-5-(benzyloxy)-4-(1-ethoxyethoxy)-3-methylpentyl](dioxo)phenyl-lambda(6)-sulfane | C23H32O5S | 详情 | 详情 | |
| (VIII) | 35140 | 3-methyltetrahydro-2H-pyran-2-one | C6H10O2 | 详情 | 详情 | |
| (IX) | 35141 | (2S,3S,5R,6S,11R)-2-[(benzyloxy)methyl]-3,11-dimethyl-1,7-dioxaspiro[5.5]undec-5-yl phenyl sulfone; (2S,3S,5R,6S,11R)-2-[(benzyloxy)methyl]-3,11-dimethyl-5-(phenylsulfonyl)-1,7-dioxaspiro[5.5]undecane | C25H32O5S | 详情 | 详情 |
合成路线16
该中间体在本合成路线中的序号：(XIV)Intermediate (III) is prepared by protection of either 4-iodopyrazole (XIIIa) or 4-bromopyrazole (XIIIb) with ethyl vinyl ether (XIV) by means of HCl in toluene or CH2Cl2 to give the corresponding (1-ethoxyethyl)pyrazoles (XVa) and (XVb). Finally, pyrazole (XVa) is submitted to metal-halogen exchange by means of i-PrMgCl in THF, followed by condensation with isopropyl pinacol borate (XVI) (obtained by reaction of pinacol [XVII] with triisopropyl borate at reflux), or pyrazole (XVb) is condensed with methyl pinacol borate (XVIII) by means of i-PrMgCl·LiCl in THF .
| 【1】 Lin, Q., Meloni, D., Pan, Y. et al. Enantioselective synthesis of Janus kinase inhibitor INCB018424 via an organocatalytic aza-Michael reaction. Org Lett 2009, 11(9): 1999-2002. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XIIIa) | 69178 | 4-iodopyrazole;4-Iodo-1H-pyrazole | 3469-69-0 | C3H3IN2 | 详情 | 详情 |
| (XIIIb) | 69179 | C3H3BrN2 | 详情 | 详情 | ||
| (XVa) | 69180 | 1-(1-ethoxyethyl)-4-iodo-1H-pyrazole | C7H11IN2O | 详情 | 详情 | |
| (XVb) | 69181 | 4-bromo-1-(1-ethoxyethyl)-1H-pyrazole | C7H11BrN2O | 详情 | 详情 | |
| (III) | 68071 | 1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole | C13H23BN2O3 | 详情 | 详情 | |
| (XIV) | 18762 | 1-Ethoxyethylene; Ethyl vinyl ether；Ethoxyethene | 109-92-2 | C4H8O | 详情 | 详情 |
| (XVI) | 67808 | Isopropyl pinacolyl borate;Isopropoxyboronic acid pinacol ester;2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | 61676-62-8 | C9H19BO3 | 详情 | 详情 |
| (XVII) | 68108 | 2,3-Dimethyl-2,3-butanediol;2,3-Dimethylbutane-2,3-diol;Tetramethylethylene glycol;pinacol | 76-09-5 | C6H14O2 | 详情 | 详情 |
| (XVIII) | 69182 | Methoxyboronic acid pinacol ester;2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | 1195-66-0 | C7H15BO3 | 详情 | 详情 |