• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】45438

【品名】[4-(1-ethoxyethoxy)-3-methoxyphenyl]lithium

【CA登记号】

【 分 子 式 】C11H15LiO3

【 分 子 量 】202.1793

【元素组成】C 65.35% H 7.48% Li 3.43% O 23.74%

与该中间体有关的原料药合成路线共 2 条

合成路线1

该中间体在本合成路线中的序号:(IV)

The protection of 4-bromo-2-methoxyphenol (I) with ethyl vinyl ether (II) and TsOH in dichloromethane gives the ethoxyethyl ether (III), which is treated with n-BuLi in THF to yield the phenyl lithium compound (IV). The reaction of (IV) with 2H-labeled DMF (V), followed by hydrolysis with HCl, affords the labeled 4-hydroxy-3-methoxybenzaldehyde (VI), which is finally condensed with pentane-2,4-dione (VII) by means of B2O3 and tetrahydroquinoline in DMF.

1 Threadgill, M.D.; Parveen, I.; Labelled compounds of interest as antitumour agents - VII. [H-2]- and [C-14]-curcumin. J Label Compd Radiopharm 2000, 43, 9, 883.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 45436 4-bromo-2-methoxyphenol 7368-78-7 C7H7BrO2 详情 详情
(II) 18762 1-Ethoxyethylene; Ethyl vinyl ether;Ethoxyethene 109-92-2 C4H8O 详情 详情
(III) 45437 5-bromo-2-(1-ethoxyethoxy)phenyl methyl ether; 4-bromo-1-(1-ethoxyethoxy)-2-methoxybenzene C11H15BrO3 详情 详情
(IV) 45438 [4-(1-ethoxyethoxy)-3-methoxyphenyl]lithium C11H15LiO3 详情 详情
(V) 33491 Dimethylformamide 68-12-2 C3H7NO 详情 详情
(V) 45439 dimethylformamide C3H7NO 详情 详情
(VI) 22701 4-hydroxy-3-methoxybenzaldehyde 121-33-5 C8H8O3 详情 详情
(VI) 45440 4-hydroxy-3-methoxybenzaldehyde 21-59-0 C8H8O3 详情 详情
(VII) 11620 2,4-Pentanedione;acetylacetone 123-54-6 C5H8O2 详情 详情

合成路线2

该中间体在本合成路线中的序号:(IV)

The protection of 4-bromo-2-methoxyphenol (I) with ethyl vinyl ether (II) and TsOH in dichloromethane gives the ethoxyethyl ether (III), which is treated with n-BuLi in THF to yield the phenyl lithium compound (IV). The reaction of (IV) with 14C-labeled DMF (V), followed by hydrolysis with HCl, affords the labeled 4-hydroxy-3-methoxybenzaldehyde (VI), which is finally condensed with pentane-2,4-dione (VII) by means of B2O3 and tetrahydroquinoline in DMF.

1 Threadgill, M.D.; Parveen, I.; Labelled compounds of interest as antitumour agents - VII. [H-2]- and [C-14]-curcumin. J Label Compd Radiopharm 2000, 43, 9, 883.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 45436 4-bromo-2-methoxyphenol 7368-78-7 C7H7BrO2 详情 详情
(II) 18762 1-Ethoxyethylene; Ethyl vinyl ether;Ethoxyethene 109-92-2 C4H8O 详情 详情
(III) 45437 5-bromo-2-(1-ethoxyethoxy)phenyl methyl ether; 4-bromo-1-(1-ethoxyethoxy)-2-methoxybenzene C11H15BrO3 详情 详情
(IV) 45438 [4-(1-ethoxyethoxy)-3-methoxyphenyl]lithium C11H15LiO3 详情 详情
(V) 33491 Dimethylformamide 68-12-2 C3H7NO 详情 详情
(V) 45441 dimethylformamide C3H7NO 详情 详情
(VI) 22701 4-hydroxy-3-methoxybenzaldehyde 121-33-5 C8H8O3 详情 详情
(VI) 45442 4-hydroxy-3-methoxybenzaldehyde C8H8O3 详情 详情
(VII) 11620 2,4-Pentanedione;acetylacetone 123-54-6 C5H8O2 详情 详情
Extended Information