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【结 构 式】 
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【药物名称】Tetrofosmin [99m-Tc], Technetium (99mTc) tetrofosmin, PPN-1011, P-53(uncomplexed), Myoview 【化学名称】(OC-6-11)-Bis[6,9-bis(2-ethoxyethyl)-3,12-dioxa-6,9-diphosphatetradecane-P,P']dioxotechnetium(1+)-99Tc 【CA登记号】127455-27-0, 127502-06-1 (ligand) 【 分 子 式 】C36H80O10P4Tc 【 分 子 量 】895.8344 |
【开发单位】Amersham (Originator) 【药理作用】DIAGNOSTIC AGENTS, Radiopharmaceuticals, Radiopharmaceuticals for Myocardial Imaging |
合成路线1
Tetrofosmin (III) was prepared by condensation of 1,2-diphosphinoethane (I) with ethyl vinyl ether (II) in the presence of AIBN. The title technetium complex was then prepared by treatment of a solution of sodium pertechnetate with a reducing agent in the presence of the bis-phosphine ligand (III).
| 【1】 Archer, C.M.; Dilworth, J.R.; Jobanputra, P.; Latham, I.A.; Thompson, R.M. (Amersham plc); New cores for technetium radiopharmaceuticals. JP 2002060397; WO 9103262 . |
| 【2】 Kelly, J.D.; Chiu, K.W.; Latham, I.A. (Amersham plc); Ligands and cationic complexes thereof with technetium-99m. EP 0337654; JP 1997328495 . |
| 【3】 Kelly, J.D.; et al.; Technetium-99m-tetrofosmin as a new radiopharmaceutical for myocardial perfusion imaging. J Nucl Med 1993, 34, 2, 222. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 56546 | 1,2-Bis(phosphino)ethane | 5518-62-7 | C2H8P2 | 详情 | 详情 |
| (II) | 18762 | 1-Ethoxyethylene; Ethyl vinyl ether；Ethoxyethene | 109-92-2 | C4H8O | 详情 | 详情 |
| (III) | 56547 | 2-[{2-[bis(2-ethoxyethyl)phosphino]ethyl}(2-ethoxyethyl)phosphino]ethyl ethyl ether; 6,9-bis(2-ethoxyethyl)-3,12-dioxa-6,9-diphosphatetradecane | C18H40O4P2 | 详情 | 详情 |
Extended Information