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【结 构 式】 
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【分子编号】10753 【品名】Nicotinoyl chloride 【CA登记号】 |
【 分 子 式 】C6H4ClNO 【 分 子 量 】141.5566 【元素组成】C 50.91% H 2.85% Cl 25.04% N 9.89% O 11.3% |
合成路线1
该中间体在本合成路线中的序号：(I)This compound can be obtained by three different ways: 1) By condensation of nicotinoyl chloride (I) with 1,2-diaminopropane (IV) by means of triethylamine in pyridine. 2) By reaction of nicotinic acid (II) with 1,2-diaminopropane (IV) by means of ethyl chloroformate and triethylamine in THF. 3) By heating at 120 C a mixture of methyl nicotinate (III) with 1,2-diaminopropane (IV).
| 【1】 Mori, T.; Takaku, S.; Matsuura, F.; Murakami, Y.; Noda, Y.; Yamazaki, T.; Neichi, T.; Nakakimura, H.; Kataoka, S (Chugai Pharmaceutical Co. Ltd.); Nicotinamide derivative, process dor preparing the same and pharmaceutical composition containing the same. EP 0029602; JP 56075474 . |
| 【2】 Grau, M.; Serradell, M.N.; Castaner, J.; Blancafort, P.; AVS. Drugs Fut 1983, 8, 6, 485. |
合成路线2
该中间体在本合成路线中的序号：(II)The acylation of 8-hydroxy-1,2,3,4-tetrahydroquinoline (I) with nicotinoyl chloride (II) by means of triethylamine in benzene gives 8-hydroxy-1-nicotinoyl-1,2,3,4-tetrahydroquinoline (III), which is condensed with epichlorohydrin (IV) by means of potassium tert-butoxide in DMF to yield 1-nicotinoyl-8-(2,3-epoxy-1-propoxy)-1,2,3,4-tetrahydroquinoline (V). Finally, this compound is condensed with isopropylamine (VI) in ethanol.
| 【1】 Graewinger, O.; Raabe, T.; Beyerle, R.; Scholtholt, J.; Nitz, R.E.; 1-Acyl-8-(3-amino-2-hydroxypropoxy)-1,2,3,4-tetrahydroquinolines, compositions and use. DD 153368; DE 2934609; EP 0025864; JP 56034668; US 4335123 . |
| 【2】 Castaner, J.; Serradell, M.N.; Hillier, K.; Nicainoprol. Drugs Fut 1984, 9, 10, 749. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 16022 | 1,2,3,4-tetrahydro-8-quinolinol | C9H11NO | 详情 | 详情 | |
| (II) | 10753 | Nicotinoyl chloride | C6H4ClNO | 详情 | 详情 | |
| (III) | 34334 | [8-hydroxy-3,4-dihydro-1(2H)-quinolinyl](3-pyridinyl)methanone | C15H14N2O2 | 详情 | 详情 | |
| (IV) | 10146 | Epichlorohydrin; 2-(Chloromethyl)oxirane | 106-89-8 | C3H5ClO | 详情 | 详情 |
| (V) | 34335 | [8-(2-oxiranylmethoxy)-3,4-dihydro-1(2H)-quinolinyl](3-pyridinyl)methanone | C18H18N2O3 | 详情 | 详情 | |
| (VI) | 23933 | 2-Propanamine; Isopropylamine | 75-31-0 | C3H9N | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(II)Reaction of D-(+)-glucosamine HCl, with six equivalents of 3-pyridinylcarbonyl chloride (III) in hot pyridine gives a mixture of alpha and beta-penta-substituted D-(+)-glucosamines and lower substituted D-(+)-glucosamines, from which compound (III) is isolated by crystallization.
| 【1】 Murmann, W.; Ponchiroli, O.; Nicotinic derivatives of glucosamine and related pharmaceutical compositions. EP 0040433; ES 8203362; FR 2482968; US 4358441 . |
| 【2】 Subissi, A.; Glunicate. Drugs Fut 1984, 9, 12, 898. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 24036 | (3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)tetrahydro-2H-pyran-2,4,5-triol; Glucosamine | 3416-24-8 | C6H13NO5 | 详情 | 详情 |
| (II) | 10753 | Nicotinoyl chloride | C6H4ClNO | 详情 | 详情 | |
| (III) | 34278 | (2R,3R,4R,5R,6R)-5-[(3-pyridinylcarbonyl)amino]-4,6-bis[(3-pyridinylcarbonyl)oxy]-2-[[(3-pyridinylcarbonyl)oxy]methyl]tetrahydro-2H-pyran-3-yl nicotinate | C36H28N6O10 | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：(VIII)This compound has been obtained by two related ways: 1) The reaction of the potassium salt of the nicotinic acid with oxalyl chloride in benzene gives the corresponding anhydride (II), which is condensed with 2-hydroxy-2-phenylacetic acid (III) in dioxane to yield the expected ester (IV). The reaction of (IV) with SOCl2 in dichloromethane affords 2-(nicotinoyloxy)-2-phenylacetyl chloride (V), which is finally esterified with the cyclohexanol (VI) in dichloromethane. 2) By acylation of the 2-hydroxy-2-phenylacetic acid cis-3,3,5-trimethylcyclohexyl ester (VII) with nicotinoyl chloride (VIII) in pyridine.
| 【1】 Verga, A. (Ravizza SpA); New process for preparing cis-3,3,5-trimethylcyclohexyl-D,L-alpha-(3-pyridinecarboxy)-phenylacetate. EP 0157151 . |
| 【2】 Mauri, F. (Gaver SA); Novel spasmolytic cpd. and process for its preparation. BE 0824034; DE 2461909; FR 2256757; JP 1975105670 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 10752 | Nicotinic acid; Niacin | 59-67-6 | C6H5NO2 | 详情 | 详情 |
| (II) | 35737 | nicotinic anhydride | 16837-38-0 | C12H8N2O3 | 详情 | 详情 |
| (III) | 28161 | 2-hydroxy-2-phenylacetic acid | 611-72-3 | C8H8O3 | 详情 | 详情 |
| (IV) | 35738 | 2-phenyl-2-[(3-pyridinylcarbonyl)oxy]acetic acid | C14H11NO4 | 详情 | 详情 | |
| (V) | 35739 | 2-chloro-2-oxo-1-phenylethyl nicotinate | C14H10ClNO3 | 详情 | 详情 | |
| (VI) | 35740 | (1R,5R)-3,3,5-trimethylcyclohexanol | C9H18O | 详情 | 详情 | |
| (VII) | 35741 | (1R,5R)-3,3,5-trimethylcyclohexyl 2-hydroxy-2-phenylacetate | 456-59-7 | C17H24O3 | 详情 | 详情 |
| (VIII) | 10753 | Nicotinoyl chloride | C6H4ClNO | 详情 | 详情 |
合成路线5
该中间体在本合成路线中的序号：(II)The reaction of nicotinic acid (I) with SOCl2 gives the corresponding acyl chloride (II), which is condensed with 2-methylpyrazolo[1,5-a]pyridine (III) by heating at 160-80 C or in refluxing dioxane, yielding 2-methyl-3-(3-pyridylcarbonyl)pyrazolo[1,5-a]pyridine (IV). Finally, this compound is hydrogenated with H2 over Pd/C in ethanol at 13 Atm. pressure and 55-8 C.
| 【1】 Hausberg, H.-H.; Koppe, V.; Poetsch, E.; Saiko, O.; Seyfried, C. (Merck Patent GmbH); Indolalkylamines, pharmaceutical compsns. containing them and process for their preparation. EP 0007399 . |
| 【2】 Castaner, J.; Prous, J.; KC-764. Drugs Fut 1991, 16, 2, 108. |
| 【3】 Awano, K.; Segawa, M.; Suzue, S.; Synthesis of 3-substituted pyrazolo[1,5-a]pyridine derivatives with inhibitory activity on platelet aggregation. I. Chem Pharm Bull 1986, 34, 7, 2828-32. |
合成路线6
该中间体在本合成路线中的序号：(I)1) The reaction of 3-pyridylcarbonyl chloride (I) with (3S,4R)-2-[3-[1(R)-hyroxyethyl]-2-oxo-4-sulfanylazetidin-1-yl]-2-(triphenylphosphoranylidene)acetic acid allyl ester silver salt (II) in dichloromethane containing pyridine gives the substituted phosphorane (III), which is cyclized in refluxing benzene to afford (5R,6S)-6-[1(R)-hydroxyethyl]-2-(3-pyridyl)-2-penem-3-carboxylic acid allyl ester (IV). The deprotection of (IV) by means of triphenylphosphine, tetrakis(triphenylphosphine)palladium and acetic acid yields the free acid (V), which is finally esterified with bromomethyl acetate (VI) in DMF.
| 【1】 Mealy, M.; Castaner, J.; TMA-230. Drugs Fut 1996, 21, 5, 493. |
| 【2】 Bedeschi, A.; Visentin, G.; Perrone, E.; et al.; Synthesis and structure-activity relations in the class 2-(pyridyl)penems. J Antibiot 1990, 43, 3, 306-13. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 10753 | Nicotinoyl chloride | C6H4ClNO | 详情 | 详情 | |
| (II) | 12676 | (3S,4R)-2-[3-(1(R)-Hydroxyethyl)-2-oxo-4-sulfanylazetidin-1-yl]-2-(triphenylphosphanylidene)acetic acid allyl ester S-silver salt | C28H27AgNO4PS | 详情 | 详情 | |
| (III) | 12677 | allyl 2-[(3S,4R)-3-[(1R)-1-hydroxyethyl]-2-oxo-4-[(3-pyridinylcarbonyl)sulfanyl]azetidinyl]-2-(triphenylphosphoranylidene)acetate | C34H31N2O5PS | 详情 | 详情 | |
| (IV) | 12678 | allyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-(3-pyridinyl)-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate | C16H16N2O4S | 详情 | 详情 | |
| (V) | 12679 | (5R,6S)-6-[(1R)-1-Hydroxyethyl]-7-oxo-3-(3-pyridinyl)-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid | C13H12N2O4S | 详情 | 详情 | |
| (VI) | 12680 | bromomethyl acetate | 590-97-6 | C3H5BrO2 | 详情 | 详情 |
合成路线7
该中间体在本合成路线中的序号：(I)2) The reaction of 3-pyridylcarbonyl chloride (I) with (3S,4R)-2-[3-[1(R)-(allyloxycarbonyloxy)ethyl]-2-oxo-4-sulfanylazetidin-1-yl]-2-(triphenylphosphoranylidene)acetic acid allyl ester silver salt (VII) in dichloromethane containing pyridine gives the substituted phosphorane (VIII), which is cyclized in refluxing toluene to afford (5R,6S)-6-[1(R)-(allyloxycarbonyloxy)ethyl]-2-(3-pyridyl)-2-penem-3-carboxylic acid allyl ester (IX). The deprotection of (IX) with tetrakis(triphenylphosphine)palladium, tributyltin hydride and NaHCO3 in THF gives the free acid (X) as the sodium salt, which is finally esterified with bromomethyl acetate.
| 【1】 Mealy, M.; Castaner, J.; TMA-230. Drugs Fut 1996, 21, 5, 493. |
| 【2】 Lang, M. (Novartis AG); 2-Pyridyl-penem cpds. EP 0246187; JP 1987263183; US 4826832 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 10753 | Nicotinoyl chloride | C6H4ClNO | 详情 | 详情 | |
| (VI) | 12680 | bromomethyl acetate | 590-97-6 | C3H5BrO2 | 详情 | 详情 |
| (VII) | 12681 | (3S,4R)-2-[3-[1(R)-(Allyloxycarbonyloxy)ethyl]-2-oxo-4-sulfanylazetidin-1-yl]-2-(triphenylphosphanylidene)acetic acid allyl ester S-silver salt | C32H31AgNO6PS | 详情 | 详情 | |
| (VIII) | 12682 | allyl 2-[(3S,4R)-3-((1R)-1-[[(allyloxy)carbonyl]oxy]ethyl)-2-oxo-4-[(3-pyridinylcarbonyl)sulfanyl]azetidinyl]-2-(triphenylphosphoranylidene)acetate | C38H35N2O7PS | 详情 | 详情 | |
| (IX) | 12683 | allyl (5R,6S)-6-((1R)-1-[[(allyloxy)carbonyl]oxy]ethyl)-7-oxo-3-(3-pyridinyl)-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate | C20H20N2O6S | 详情 | 详情 | |
| (X) | 12684 | sodium (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-(3-pyridinyl)-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate | C13H11N2NaO4S | 详情 | 详情 |
合成路线8
该中间体在本合成路线中的序号：(V)The preparation of KW-3196 is as follows: Reaction of 1,4:3,6-dianhydro-D-glucitol 5-methanesulfonate (I) (1) with piperazine (II) afforded (III), which was nitrated with fuming HNO3 to give the nitrate ester (IV). Nicotynoylation of (IV) gave KW-319).
| 【1】 Klessing, K.; Chatterjee, S.S. (Dr. Willmar Schwabe); Alkylaminodeoxy-1,4:3,6-dianhydrohexitol nitrates substituted by purine bases and their pharmaceutical compositions. EP 0044927 . |
| 【2】 Suzuki, F.; Hayashi, H.; Kuroda, T.; Kubo, K.; Ikeda, J. (Kyowa Hakko Kogyo Co., Ltd.); Hexitol derivatives having vasodilative activity. EP 0393574; JP 1991218381; US 5053408 . |
| 【3】 Ueno, H.; Hayashi, H.; Suzuki, F.; Synthesis of stereoisomers of 1,4:3,6-dianhydrohexitol nitrate derivative, KF14124. Bioorg Med Chem Lett 1992, 2, 1187-92. |
| 【4】 Suzuki, F.; KW-3196. Drugs Fut 1992, 17, 11, 995. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 14844 | (3R,3aS,6S,6aR)-6-hydroxyhexahydrofuro[3,2-b]furan-3-yl methanesulfonate | C7H12O6S | 详情 | 详情 | |
| (II) | 10355 | Diethylenediamine; Piperazine | 110-85-0 | C4H10N2 | 详情 | 详情 |
| (III) | 14845 | (3S,3aR,6S,6aR)-6-piperazinohexahydrofuro[3,2-b]furan-3-ol | C10H18N2O3 | 详情 | 详情 | |
| (IV) | 14846 | 1-[(3S,3aR,6S,6aS)-6-(nitrooxy)hexahydrofuro[3,2-b]furan-3-yl]piperazine | C10H17N3O5 | 详情 | 详情 | |
| (V) | 10753 | Nicotinoyl chloride | C6H4ClNO | 详情 | 详情 |
合成路线9
该中间体在本合成路线中的序号：(II)The compound S 16961-1 was synthesized in three steps from solketal (I) by acylation with nicotinoyl chloride (II), deprotection of the isopropylidene ketal (III) by heating in dilute aqueous acetic acid and acylation of this key intermediate (IV) with a slight excess of palmitoyl chloride (V) in the presence of triethylamine and 4-dimethylaminopyridine (DMAP) as catalyst. The enantiomers of S 16961-1 were obtained independently in one step from the commercially available (d)- and (l)-1,2-dipalmitoyl glycerols by acylation with nicotinoyl chloride in the presence of triethylamine. The enantiomers were found equiactive and therefore were not pursued individually.
| 【1】 Brown, G.; Albers, J.J.; Fisher, L.D.; Schaeffer, S.; Lin, J.; Kaplan, C.; Zhao, X.; Bisson, B.; Fitzpatrick, V.; Dodge, H.; Regression of coronary artery disease as a result of intensive lipid lowering therapy in men with high level of apolipoprotein B. New Engl J Med 1990, 323, 19, 1289-98. |
| 【2】 Cordi, A.A.; Duhault, J.; Laudignon, N.; Castagne, I.; S 16961-1. Drugs Fut 1996, 21, 5, 490. |
| 【3】 Cordi, A.; Lacoste, J.-M.; Duhault, J.; Espinal, J.; Boulanger, M. (ADIR et Cie.); Diacylglycerol nicotinates. EP 0574312; JP 1994056786; US 5385920 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 16476 | 2,2-dimethyl-4-hydroxymethyl-1,3-dioxolane; (2,2-dimethyl-1,3-dioxolan-4-yl)methanol; 2,3-o-Isopropylideneglycerol | 100-79-8 | C6H12O3 | 详情 | 详情 |
| (II) | 10753 | Nicotinoyl chloride | C6H4ClNO | 详情 | 详情 | |
| (III) | 16478 | (2,2-dimethyl-1,3-dioxolan-4-yl)methyl nicotinate | C12H15NO4 | 详情 | 详情 | |
| (IV) | 16479 | 2,3-dihydroxypropyl nicotinate | C9H11NO4 | 详情 | 详情 | |
| (V) | 16480 | Palmitoyl Chloride; hexadecanoyl chloride | 112-67-4 | C16H31ClO | 详情 | 详情 |
合成路线10
该中间体在本合成路线中的序号：(XVIII)Electrophilic bromination of chromene (XII) with N-bromosuccinimide in moist DMSO produced the trans-bromohydrin (XIII). The racemic (XIII) was then resolved by esterification with (R)-alpha-methoxyphenylacetic acid (XIV), using DCC as the coupling reagent, and subsequent chromatographic separation of the diastereomeric mixture. Hydrolysis of the desired bromoester isomer (XV) under basic conditions gave rise to the chiral cis-epoxide (XVI). The target amino alcohol (XVII) was then obtained by regioselective ring opening of epoxide (XVI) with ethanolic ammonia in a pressure vessel. Finally, coupling of (XVII) with nicotinoyl chloride (XVIII) furnished the title amide.
| 【1】 Manley, P.W. (Novartis AG; Novartis Deutschland GmbH); 2,2-Dialkyl- and 2,2-dialkyl-3, 4-dihydro-3-hydroxy-2H-1-benzopyrans, their use as pharmaceuticals. EP 0623129; WO 9412493 . |
| 【2】 Manley, P.W. (Novartis AG); 2,2-Dialkyl- and 2,2-dialkyl-3, 4-dihydro-3-hydroxy-2H-1-benzopyrans. US 5574049 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XII) | 50058 | 4-(2,2-dimethyl-2H-chromen-6-yl)-2-methylpyridine | C17H17NO | 详情 | 详情 | |
| (XIII) | 50059 | (3R,4R)-4-bromo-2,2-dimethyl-6-(2-methyl-4-pyridinyl)-3,4-dihydro-2H-chromen-3-ol | C17H18BrNO2 | 详情 | 详情 | |
| (XIV) | 50060 | (2R)-2-methoxy-2-phenylethanoic acid | 3966-32-3 | C9H10O3 | 详情 | 详情 |
| (XV) | 50061 | (3R,4R)-4-bromo-2,2-dimethyl-6-(2-methyl-4-pyridinyl)-3,4-dihydro-2H-chromen-3-yl (2R)-2-methoxy-2-phenylethanoate | C26H26BrNO4 | 详情 | 详情 | |
| (XVI) | 50062 | 4-[(1aS,7bS)-2,2-dimethyl-1a,7b-dihydro-2H-oxireno[2,3-c]chromen-6-yl]-2-methylpyridine | C17H17NO2 | 详情 | 详情 | |
| (XVII) | 50063 | (3S,4R)-4-amino-2,2-dimethyl-6-(2-methyl-4-pyridinyl)-3,4-dihydro-2H-chromen-3-ol | C17H20N2O2 | 详情 | 详情 | |
| (XVIII) | 10753 | Nicotinoyl chloride | C6H4ClNO | 详情 | 详情 |
合成路线11
该中间体在本合成路线中的序号：(V)The chlorination of norharmane (I) by means of N-chlorosuccinimide in aqueous HCl affords 7-chloro-beta-carboline (II). Subsequent electrophilic nitration of (II) with concentrated HNO3 gives rise to the 9-nitro compound (III), which is further reduced to the corresponding amine (IV) with SnCl2/HCl. Acylation of amine (IV) with nicotinoyl chloride (V) in pyridine then furnishes the target nicotinamide derivative.
| 【1】 Adams, J.; Soucy, F.; Grenier, L.; Castro, A.; Mazdiyasni, H.; Hancock, W.W.; Ritzeler, O.; Palombella, V. (Aventis Pharma Deutschland GmbH); Substd. beta-carbolines as IkB-kinase inhibiting activity. EP 1134221; EP 1209158; EP 1268477; JP 2003527394; US 2002099068; US 6627637; WO 0168648 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 64286 | 9H-beta-carboline | C11H8N2 | 详情 | 详情 | |
| (II) | 64287 | 6-chloro-9H-beta-carboline | C11H7ClN2 | 详情 | 详情 | |
| (III) | 64288 | 6-chloro-8-nitro-9H-beta-carboline | C11H6ClN3O2 | 详情 | 详情 | |
| (IV) | 64289 | 6-chloro-9H-beta-carbolin-8-amine; 6-chloro-9H-beta-carbolin-8-ylamine | C11H8ClN3 | 详情 | 详情 | |
| (V) | 10753 | Nicotinoyl chloride | C6H4ClNO | 详情 | 详情 |