【结 构 式】 |
【分子编号】34278 【品名】(2R,3R,4R,5R,6R)-5-[(3-pyridinylcarbonyl)amino]-4,6-bis[(3-pyridinylcarbonyl)oxy]-2-[[(3-pyridinylcarbonyl)oxy]methyl]tetrahydro-2H-pyran-3-yl nicotinate 【CA登记号】 |
【 分 子 式 】C36H28N6O10 【 分 子 量 】704.65276 【元素组成】C 61.36% H 4.01% N 11.93% O 22.71% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)Reaction of D-(+)-glucosamine HCl, with six equivalents of 3-pyridinylcarbonyl chloride (III) in hot pyridine gives a mixture of alpha and beta-penta-substituted D-(+)-glucosamines and lower substituted D-(+)-glucosamines, from which compound (III) is isolated by crystallization.
【1】 Murmann, W.; Ponchiroli, O.; Nicotinic derivatives of glucosamine and related pharmaceutical compositions. EP 0040433; ES 8203362; FR 2482968; US 4358441 . |
【2】 Subissi, A.; Glunicate. Drugs Fut 1984, 9, 12, 898. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 24036 | (3R,4R,5S,6R)-3-amino-6-(hydroxymethyl)tetrahydro-2H-pyran-2,4,5-triol; Glucosamine | 3416-24-8 | C6H13NO5 | 详情 | 详情 |
(II) | 10753 | Nicotinoyl chloride | C6H4ClNO | 详情 | 详情 | |
(III) | 34278 | (2R,3R,4R,5R,6R)-5-[(3-pyridinylcarbonyl)amino]-4,6-bis[(3-pyridinylcarbonyl)oxy]-2-[[(3-pyridinylcarbonyl)oxy]methyl]tetrahydro-2H-pyran-3-yl nicotinate | C36H28N6O10 | 详情 | 详情 |
Extended Information