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【结 构 式】 
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【分子编号】10754 【品名】2-Methylpyrazolo[1,5-a]pyridine 【CA登记号】 |
【 分 子 式 】C8H8N2 【 分 子 量 】132.165 【元素组成】C 72.7% H 6.1% N 21.2% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The reaction of nicotinic acid (I) with SOCl2 gives the corresponding acyl chloride (II), which is condensed with 2-methylpyrazolo[1,5-a]pyridine (III) by heating at 160-80 C or in refluxing dioxane, yielding 2-methyl-3-(3-pyridylcarbonyl)pyrazolo[1,5-a]pyridine (IV). Finally, this compound is hydrogenated with H2 over Pd/C in ethanol at 13 Atm. pressure and 55-8 C.
| 【1】 Hausberg, H.-H.; Koppe, V.; Poetsch, E.; Saiko, O.; Seyfried, C. (Merck Patent GmbH); Indolalkylamines, pharmaceutical compsns. containing them and process for their preparation. EP 0007399 . |
| 【2】 Castaner, J.; Prous, J.; KC-764. Drugs Fut 1991, 16, 2, 108. |
| 【3】 Awano, K.; Segawa, M.; Suzue, S.; Synthesis of 3-substituted pyrazolo[1,5-a]pyridine derivatives with inhibitory activity on platelet aggregation. I. Chem Pharm Bull 1986, 34, 7, 2828-32. |
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