• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】10754

【品名】2-Methylpyrazolo[1,5-a]pyridine

【CA登记号】

【 分 子 式 】C8H8N2

【 分 子 量 】132.165

【元素组成】C 72.7% H 6.1% N 21.2%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

The reaction of nicotinic acid (I) with SOCl2 gives the corresponding acyl chloride (II), which is condensed with 2-methylpyrazolo[1,5-a]pyridine (III) by heating at 160-80 C or in refluxing dioxane, yielding 2-methyl-3-(3-pyridylcarbonyl)pyrazolo[1,5-a]pyridine (IV). Finally, this compound is hydrogenated with H2 over Pd/C in ethanol at 13 Atm. pressure and 55-8 C.

1 Hausberg, H.-H.; Koppe, V.; Poetsch, E.; Saiko, O.; Seyfried, C. (Merck Patent GmbH); Indolalkylamines, pharmaceutical compsns. containing them and process for their preparation. EP 0007399 .
2 Castaner, J.; Prous, J.; KC-764. Drugs Fut 1991, 16, 2, 108.
3 Awano, K.; Segawa, M.; Suzue, S.; Synthesis of 3-substituted pyrazolo[1,5-a]pyridine derivatives with inhibitory activity on platelet aggregation. I. Chem Pharm Bull 1986, 34, 7, 2828-32.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 10752 Nicotinic acid; Niacin 59-67-6 C6H5NO2 详情 详情
(II) 10753 Nicotinoyl chloride C6H4ClNO 详情 详情
(III) 10754 2-Methylpyrazolo[1,5-a]pyridine C8H8N2 详情 详情
(IV) 10755 (2-Methylpyrazolo[1,5-a]pyridin-3-yl)(3-pyridinyl)methanone C14H11N3O 详情 详情
Extended Information