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【结 构 式】 
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【分子编号】64286 【品名】9H-beta-carboline 【CA登记号】 |
【 分 子 式 】C11H8N2 【 分 子 量 】168.198 【元素组成】C 78.55% H 4.79% N 16.66% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The chlorination of norharmane (I) by means of N-chlorosuccinimide in aqueous HCl affords 7-chloro-beta-carboline (II). Subsequent electrophilic nitration of (II) with concentrated HNO3 gives rise to the 9-nitro compound (III), which is further reduced to the corresponding amine (IV) with SnCl2/HCl. Acylation of amine (IV) with nicotinoyl chloride (V) in pyridine then furnishes the target nicotinamide derivative.
| 【1】 Adams, J.; Soucy, F.; Grenier, L.; Castro, A.; Mazdiyasni, H.; Hancock, W.W.; Ritzeler, O.; Palombella, V. (Aventis Pharma Deutschland GmbH); Substd. beta-carbolines as IkB-kinase inhibiting activity. EP 1134221; EP 1209158; EP 1268477; JP 2003527394; US 2002099068; US 6627637; WO 0168648 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 64286 | 9H-beta-carboline | C11H8N2 | 详情 | 详情 | |
| (II) | 64287 | 6-chloro-9H-beta-carboline | C11H7ClN2 | 详情 | 详情 | |
| (III) | 64288 | 6-chloro-8-nitro-9H-beta-carboline | C11H6ClN3O2 | 详情 | 详情 | |
| (IV) | 64289 | 6-chloro-9H-beta-carbolin-8-amine; 6-chloro-9H-beta-carbolin-8-ylamine | C11H8ClN3 | 详情 | 详情 | |
| (V) | 10753 | Nicotinoyl chloride | C6H4ClNO | 详情 | 详情 |
Extended Information