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【结 构 式】 
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【药物名称】Nicaraven, AVS, Antevas 【化学名称】1,2-Bis(nicotinamido)propane 【CA登记号】79455-30-4 【 分 子 式 】C15H16N4O2 【 分 子 量 】284.32037 |
【开发单位】Chugai (Originator), Novartis (Comarketer) 【药理作用】Cerebrovascular Diseases, Treatment of, NEUROLOGIC DRUGS, Stroke, Treatment of, Free Radical Scavengers, Lipid Peroxidation Inhibitors |
合成路线1
This compound can be obtained by three different ways: 1) By condensation of nicotinoyl chloride (I) with 1,2-diaminopropane (IV) by means of triethylamine in pyridine. 2) By reaction of nicotinic acid (II) with 1,2-diaminopropane (IV) by means of ethyl chloroformate and triethylamine in THF. 3) By heating at 120 C a mixture of methyl nicotinate (III) with 1,2-diaminopropane (IV).
| 【1】 Mori, T.; Takaku, S.; Matsuura, F.; Murakami, Y.; Noda, Y.; Yamazaki, T.; Neichi, T.; Nakakimura, H.; Kataoka, S (Chugai Pharmaceutical Co. Ltd.); Nicotinamide derivative, process dor preparing the same and pharmaceutical composition containing the same. EP 0029602; JP 56075474 . |
| 【2】 Grau, M.; Serradell, M.N.; Castaner, J.; Blancafort, P.; AVS. Drugs Fut 1983, 8, 6, 485. |