(Z)-2-(2-aminothiazol-4-yl)-2-((2-methoxy-2-oxoethoxy)imino)acetic acid -Drug Synthesis Database

【结构式】

【分子编号】69638

【品名】(Z)-2-(2-aminothiazol-4-yl)-2-((2-methoxy-2-oxoethoxy)imino)acetic acid

【CA登记号】80544-17-8

【分子式】C₈H₉N₃O₅S

【分子量】259.243

【元素组成】C 37.06% H 3.50% N 16.21% O 30.86% S 12.37%

与该中间体有关的原料药合成路线共 2 条

该中间体在本合成路线中的序号：(V)

【1】 Lopez M,Rodriguez Z,Gonzalez M,et al.Synthesis of (Z)-2-(2-formamido-4-thiazolyl)-2-(substituted alkoxyimino)acetic acids.Farmaco,2000,55:40.
【2】 Parthasaradhi Reddy B,Rathnakar Reddy K,Raji Reddy R,et al.An improved process for the preparation of ceficime:WO,Patent 2,006,103,686,2006.
【3】程先波，胡立蓬，叶树祥，等.头孢克肟的制备方法：CN,Patent 101,319,246,2008.
【4】潘行远.一种头孢克肟的合成方法：CN,Patent 101,016,305,2007.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	27907	Acetoacetic acid tert-butyl ester;3-Oxo-butanoic acid 1,1-dimethylethyl estertert-butyl 3-oxobutanoate	1694-31-1	C₈H₁₄O₃	详情	详情
(II)	69635	(Z)-tert-butyl 2-(hydroxyimino)-3-oxobutanoate		C₈H₁₃NO₄	详情	详情
(III)	69636	(Z)-tert-butyl 2-((2-methoxy-2-oxoethoxy)imino)-3-oxobutanoate		C₁₁H₁₇NO₆	详情	详情
(IV)	69637	4-Chloro-2-[(2-methoxy-2-oxoethoxy)imino]-3-oxobutanoic acid；4-Chloro-2-(Z)-methoxycarbonylmethoxyimino-3-oxobutyric acid;(Z)-4-chloro-2-((2-methoxy-2-oxoethoxy)imino)-3-oxobutanoic acid	95759-10-7	C₇H₈ClNO₆	详情	详情
(V)	69638	(Z)-2-(2-aminothiazol-4-yl)-2-((2-methoxy-2-oxoethoxy)imino)acetic acid	80544-17-8	C₈H₉N₃O₅S	详情	详情
(VI)	69639	(Z)-methyl 2-(((1-(2-aminothiazol-4-yl)-2-(benzo[d]thiazol-2-ylthio)-2-oxoethylidene)amino)oxy)acetate	246035-38-1	C₁₅H₁₂N₄O₄S₃	详情	详情
(VII)	69640	(6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-((2-methoxy-2-oxoethoxy)imino)acetamido)-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid		C₁₇H₁₇N₅O₇S₂	详情	详情
(VIII)	10257	methyl 2-chloroacetate; methyl chloroacetate	96-34-4	C₃H₅ClO₂	详情	详情
(IX)	10180	Thiourea	62-56-6	CH₄N₂S	详情	详情
(X)	64882	(6R,7R)-7-amino-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid	79349-82-9	C₉H₁₀N₂O₃S	详情	详情

该中间体在本合成路线中的序号：(I)

【1】 Deshpande PB,Luthra PK.Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds:US,Patent 6,388,070,2002.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	69638	(Z)-2-(2-aminothiazol-4-yl)-2-((2-methoxy-2-oxoethoxy)imino)acetic acid	80544-17-8	C₈H₉N₃O₅S	详情	详情
(II)	69642	2-Phenyl-1,3,4-oxadiazole-5-thione;5-Phenyl-1,3,4-oxadiazole-2(3H)-thione;2-Phenyl-5-mercaptooxadiazole;5-Mercapto-2-phenyl-1,3,4-oxadiazole;2-Mercapto-5-phenyl-1,3,4-oxadiazole;5-phenyl-1,3,4-oxadiazole-2(3H)-thione	3004-42-0	C₈H₆N₂OS	详情	详情
(III)	69643	(Z)-methyl 2-(((1-(2-aminothiazol-4-yl)-2-oxo-2-((5-phenyl-1,3,4-oxadiazol-2-yl)thio)ethylidene)amino)oxy)acetate		C₁₆H₁₃N₅O₅S₂	详情	详情
(IV)	64882	(6R,7R)-7-amino-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid	79349-82-9	C₉H₁₀N₂O₃S	详情	详情

Extended Information