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【结 构 式】 
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【分子编号】69637 【品名】4-Chloro-2-[(2-methoxy-2-oxoethoxy)imino]-3-oxobutanoic acid；4-Chloro-2-(Z)-methoxycarbonylmethoxyimino-3-oxobutyric acid;(Z)-4-chloro-2-((2-methoxy-2-oxoethoxy)imino)-3-oxobutanoic acid 【CA登记号】95759-10-7 |
【 分 子 式 】C7H8ClNO6 【 分 子 量 】237.596 【元素组成】C 35.39% H 3.39% Cl 14.92% N 5.89% O 40.40% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)
| 【1】 Lopez M,Rodriguez Z,Gonzalez M,et al.Synthesis of (Z)-2-(2-formamido-4-thiazolyl)-2-(substituted alkoxyimino)acetic acids.Farmaco,2000,55:40. |
| 【2】 Parthasaradhi Reddy B,Rathnakar Reddy K,Raji Reddy R,et al.An improved process for the preparation of ceficime:WO,Patent 2,006,103,686,2006. |
| 【3】 程先波，胡立蓬，叶树祥，等.头孢克肟的制备方法：CN,Patent 101,319,246,2008. |
| 【4】 潘行远.一种头孢克肟的合成方法：CN,Patent 101,016,305,2007. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 27907 | Acetoacetic acid tert-butyl ester;3-Oxo-butanoic acid 1,1-dimethylethyl estertert-butyl 3-oxobutanoate | 1694-31-1 | C8H14O3 | 详情 | 详情 |
| (II) | 69635 | (Z)-tert-butyl 2-(hydroxyimino)-3-oxobutanoate | C8H13NO4 | 详情 | 详情 | |
| (III) | 69636 | (Z)-tert-butyl 2-((2-methoxy-2-oxoethoxy)imino)-3-oxobutanoate | C11H17NO6 | 详情 | 详情 | |
| (IV) | 69637 | 4-Chloro-2-[(2-methoxy-2-oxoethoxy)imino]-3-oxobutanoic acid；4-Chloro-2-(Z)-methoxycarbonylmethoxyimino-3-oxobutyric acid;(Z)-4-chloro-2-((2-methoxy-2-oxoethoxy)imino)-3-oxobutanoic acid | 95759-10-7 | C7H8ClNO6 | 详情 | 详情 |
| (V) | 69638 | (Z)-2-(2-aminothiazol-4-yl)-2-((2-methoxy-2-oxoethoxy)imino)acetic acid | 80544-17-8 | C8H9N3O5S | 详情 | 详情 |
| (VI) | 69639 | (Z)-methyl 2-(((1-(2-aminothiazol-4-yl)-2-(benzo[d]thiazol-2-ylthio)-2-oxoethylidene)amino)oxy)acetate | 246035-38-1 | C15H12N4O4S3 | 详情 | 详情 |
| (VII) | 69640 | (6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-((2-methoxy-2-oxoethoxy)imino)acetamido)-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | C17H17N5O7S2 | 详情 | 详情 | |
| (VIII) | 10257 | methyl 2-chloroacetate; methyl chloroacetate | 96-34-4 | C3H5ClO2 | 详情 | 详情 |
| (IX) | 10180 | Thiourea | 62-56-6 | CH4N2S | 详情 | 详情 |
| (X) | 64882 | (6R,7R)-7-amino-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | 79349-82-9 | C9H10N2O3S | 详情 | 详情 |
Extended Information