【结 构 式】 |
【分子编号】67051 【品名】ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate 【CA登记号】3543-73-5 |
【 分 子 式 】C14H19N3O2 【 分 子 量 】261.32388 【元素组成】C 64.35% H 7.33% N 16.08% O 12.24% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(VII)【1】 Gao LM, Wang YX, Song DQ. 2007. Synthesis of 5-[bis (2-choloethyl) amino] -1-methyl-1H-benzimidazole-2-butanoic acid hydrochloride (bendamustine hydrochloride). 中国新药杂志, 16(23): 1960~1961, 1970. |
【2】 Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877. Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877. Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877. Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877. Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877. Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877. |
【3】 Werner W, Letsch G, Ihn W. 1987. Hydrolysis products of the antitumor drug cytostasan(bendamustin). Pharmazic, 42(4): 272~273. Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 10378 | 1-Chloro-2,4-dinitrobenzene | 97-00-7 | C6H3ClN2O4 | 详情 | 详情 |
(II) | 67047 | N-methyl-2,4-dinitroaniline | 2044-88-4 | C7H7N3O4 | 详情 | 详情 |
(III) | 67048 | N1-methyl-4-nitrobenzene-1,2-diamine | 41939-61-1 | C7H9N3O2 | 详情 | 详情 |
(IV) | 15512 | Glutaric Anhydride; dihydro-2H-pyran-2,6(3H)-dione | 108-55-4 | C5H6O3 | 详情 | 详情 |
(V) | 67049 | 5-((2-(methylamino)-5-nitrophenyl)amino)-5-oxopentanoic acid | C12H15N3O5 | 详情 | 详情 | |
(VI) | 67050 | ethyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate | 3543-72-4 | C14H17N3O4 | 详情 | 详情 |
(VII) | 67051 | ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate | 3543-73-5 | C14H19N3O2 | 详情 | 详情 |
(VIII) | 10393 | Oxirane; Ethylene oxide | 75-21-8 | C2H4O | 详情 | 详情 |
(IX) | 67052 | ethyl 4-(5-(bis(2-hydroxyethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate | 3543-74-6 | C18H27N3O4 | 详情 | 详情 |
Extended Information