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【结 构 式】 
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【分子编号】67049 【品名】5-((2-(methylamino)-5-nitrophenyl)amino)-5-oxopentanoic acid 【CA登记号】 |
【 分 子 式 】C12H15N3O5 【 分 子 量 】281.26832 【元素组成】C 51.24% H 5.38% N 14.94% O 28.44% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)
| 【1】 Gao LM, Wang YX, Song DQ. 2007. Synthesis of 5-[bis (2-choloethyl) amino] -1-methyl-1H-benzimidazole-2-butanoic acid hydrochloride (bendamustine hydrochloride). 中国新药杂志， 16（23）： 1960～1961， 1970. |
| 【2】 Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877. Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877. Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877. Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877. Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877. Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877. |
| 【3】 Werner W, Letsch G, Ihn W. 1987. Hydrolysis products of the antitumor drug cytostasan(bendamustin). Pharmazic, 42(4): 272～273. Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 10378 | 1-Chloro-2,4-dinitrobenzene | 97-00-7 | C6H3ClN2O4 | 详情 | 详情 |
| (II) | 67047 | N-methyl-2,4-dinitroaniline | 2044-88-4 | C7H7N3O4 | 详情 | 详情 |
| (III) | 67048 | N1-methyl-4-nitrobenzene-1,2-diamine | 41939-61-1 | C7H9N3O2 | 详情 | 详情 |
| (IV) | 15512 | Glutaric Anhydride; dihydro-2H-pyran-2,6(3H)-dione | 108-55-4 | C5H6O3 | 详情 | 详情 |
| (V) | 67049 | 5-((2-(methylamino)-5-nitrophenyl)amino)-5-oxopentanoic acid | C12H15N3O5 | 详情 | 详情 | |
| (VI) | 67050 | ethyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate | 3543-72-4 | C14H17N3O4 | 详情 | 详情 |
| (VII) | 67051 | ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate | 3543-73-5 | C14H19N3O2 | 详情 | 详情 |
| (VIII) | 10393 | Oxirane; Ethylene oxide | 75-21-8 | C2H4O | 详情 | 详情 |
| (IX) | 67052 | ethyl 4-(5-(bis(2-hydroxyethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate | 3543-74-6 | C18H27N3O4 | 详情 | 详情 |
Extended Information