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【结 构 式】

【药物名称】Bendamustine;Treanda;Cytostasan;Ribomustin

【化学名称】5-(Bis (2-Chloroethyl) amino) -1-methyl- 2-benzimidazolebutyric acid

【CA登记号】16506-27-7;3543-75-7(HCl salt)

【 分 子 式 】C16H21Cl2N3O2

【 分 子 量 】357.10108

【开发单位】Cephalon

【药理作用】treatment for CLL and NHL

合成路线1

1 Gao LM, Wang YX, Song DQ. 2007. Synthesis of 5-[bis (2-choloethyl) amino] -1-methyl-1H-benzimidazole-2-butanoic acid hydrochloride (bendamustine hydrochloride). 中国新药杂志, 16(23): 1960~1961, 1970.
2 Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877. Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877. Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877. Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877. Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877. Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877.
3 Werner W, Letsch G, Ihn W. 1987. Hydrolysis products of the antitumor drug cytostasan(bendamustin). Pharmazic, 42(4): 272~273. Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 10378 1-Chloro-2,4-dinitrobenzene 97-00-7 C6H3ClN2O4 详情 详情
(II) 67047 N-methyl-2,4-dinitroaniline 2044-88-4 C7H7N3O4 详情 详情
(III) 67048 N1-methyl-4-nitrobenzene-1,2-diamine 41939-61-1 C7H9N3O2 详情 详情
(IV) 15512 Glutaric Anhydride; dihydro-2H-pyran-2,6(3H)-dione 108-55-4 C5H6O3 详情 详情
(V) 67049 5-((2-(methylamino)-5-nitrophenyl)amino)-5-oxopentanoic acid   C12H15N3O5 详情 详情
(VI) 67050 ethyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate 3543-72-4 C14H17N3O4 详情 详情
(VII) 67051 ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate 3543-73-5 C14H19N3O2 详情 详情
(VIII) 10393 Oxirane; Ethylene oxide 75-21-8 C2H4O 详情 详情
(IX) 67052 ethyl 4-(5-(bis(2-hydroxyethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate 3543-74-6 C18H27N3O4 详情 详情
Extended Information