N1-methyl-4-nitrobenzene-1,2-diamine -Drug Synthesis Database

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【结构式】

【分子编号】67048

【品名】N1-methyl-4-nitrobenzene-1,2-diamine

【CA登记号】41939-61-1

【分子式】C₇H₉N₃O₂

【分子量】167.16748

【元素组成】C 50.3% H 5.43% N 25.14% O 19.14%

与该中间体有关的原料药合成路线共 1 条

合成路线1

合成路线1

该中间体在本合成路线中的序号：(III)

参考文献中间体

【1】 Gao LM, Wang YX, Song DQ. 2007. Synthesis of 5-[bis (2-choloethyl) amino] -1-methyl-1H-benzimidazole-2-butanoic acid hydrochloride (bendamustine hydrochloride). 中国新药杂志， 16（23）： 1960～1961， 1970.
【2】 Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877. Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877. Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877. Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877. Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877. Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877.
【3】 Werner W, Letsch G, Ihn W. 1987. Hydrolysis products of the antitumor drug cytostasan(bendamustin). Pharmazic, 42(4): 272～273. Krueger W, Krueger G. 1983. 4-[1-methyl-5-bis[(2-chloroethyl) amino] -2-benzimidazolyl] butyric acid. Ger, (East)DD 159877.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	10378	1-Chloro-2,4-dinitrobenzene	97-00-7	C₆H₃ClN₂O₄	详情	详情
(II)	67047	N-methyl-2,4-dinitroaniline	2044-88-4	C₇H₇N₃O₄	详情	详情
(III)	67048	N1-methyl-4-nitrobenzene-1,2-diamine	41939-61-1	C₇H₉N₃O₂	详情	详情
(IV)	15512	Glutaric Anhydride; dihydro-2H-pyran-2,6(3H)-dione	108-55-4	C₅H₆O₃	详情	详情
(V)	67049	5-((2-(methylamino)-5-nitrophenyl)amino)-5-oxopentanoic acid		C₁₂H₁₅N₃O₅	详情	详情
(VI)	67050	ethyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate	3543-72-4	C₁₄H₁₇N₃O₄	详情	详情
(VII)	67051	ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate	3543-73-5	C₁₄H₁₉N₃O₂	详情	详情
(VIII)	10393	Oxirane; Ethylene oxide	75-21-8	C₂H₄O	详情	详情
(IX)	67052	ethyl 4-(5-(bis(2-hydroxyethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate	3543-74-6	C₁₈H₂₇N₃O₄	详情	详情

Extended Information