ethyl 5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-oxopentanoate -Drug Synthesis Database

【结构式】

【分子编号】61592

【品名】ethyl 5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-oxopentanoate

【CA登记号】

【分子式】C₁₅H₁₅NO₅

【分子量】289.28784

【元素组成】C 62.28% H 5.23% N 4.84% O 27.65%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VI)

The condensation of the labeled glycine (I) with phthalic anhydride (II) by heating at 160 C gives the labeled phthalimido acetic acid (III), which is treated with refluxing SOCl2 to yield the acyl chloride (IV). The condensation of (IV) with 3-iodopropionic acid ethyl ester (V) by means of the Zn/Cu couple and Pd(PPh3)4 in hot toluene affords the labeled 5-phthalimido-levulinate (VI), which is finally treated with refluxing 6N HCl to provide the target labeled aminolevulinic acid.

参考文献中间体

合成目标

【1】 Iida, K.; Kajiwara, M.; Synthesis of 13C and 15N multilabeled 5-aminolevulinic acid. J Label Compd Radiopharm 2002, 45, 2, 139.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	20436	glycine	56-40-6	C₂H₅NO₂	详情	详情
(I)	61588	GLYCINE-13C2-15N		C₂H₅NO₂	详情	详情
(II)	11900	2-Benzofuran-1,3-dione;1,2-Benzenedicarboxylic Anhydride;1,2-BENZENE DICARBOXYLIC ACID ANHYDRIDE;1,2-BENZENEDICARBONIC ACID, ANHYDRIDE;1,3-DIOXOPHTHALAN;1,3-ISOBENZOFURANDIONE;o-phthalic anhydride; Phthalic anhydride	85-44-9	C₈H₄O₃	详情	详情
(III)	10284	N-Phthaloylglycine; 2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)acetic acid	4702-13-0	C₁₀H₇NO₄	详情	详情
(III)	61589	2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetic acid		C₁₀H₇NO₄	详情	详情
(IV)	10278	2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl chloride	6780-38-7	C₁₀H₆ClNO₃	详情	详情
(IV)	61590	2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl chloride		C₁₀H₆ClNO₃	详情	详情
(V)	61591	ethyl 3-iodopropanoate		C₅H₉IO₂	详情	详情
(VI)	59167	ethyl 5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-oxopentanoate		C₁₅H₁₅NO₅	详情	详情
(VI)	61592	ethyl 5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-oxopentanoate		C₁₅H₁₅NO₅	详情	详情

Extended Information