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【结 构 式】

【分子编号】61591

【品名】ethyl 3-iodopropanoate

【CA登记号】

【 分 子 式 】C5H9IO2

【 分 子 量 】228.02973

【元素组成】C 26.34% H 3.98% I 55.65% O 14.03%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

The condensation of the labeled glycine (I) with phthalic anhydride (II) by heating at 160 C gives the labeled phthalimido acetic acid (III), which is treated with refluxing SOCl2 to yield the acyl chloride (IV). The condensation of (IV) with 3-iodopropionic acid ethyl ester (V) by means of the Zn/Cu couple and Pd(PPh3)4 in hot toluene affords the labeled 5-phthalimido-levulinate (VI), which is finally treated with refluxing 6N HCl to provide the target labeled aminolevulinic acid.

1 Iida, K.; Kajiwara, M.; Synthesis of 13C and 15N multilabeled 5-aminolevulinic acid. J Label Compd Radiopharm 2002, 45, 2, 139.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 20436 glycine 56-40-6 C2H5NO2 详情 详情
(I) 61588 GLYCINE-13C2-15N C2H5NO2 详情 详情
(II) 11900 2-Benzofuran-1,3-dione;1,2-Benzenedicarboxylic Anhydride;1,2-BENZENE DICARBOXYLIC ACID ANHYDRIDE;1,2-BENZENEDICARBONIC ACID, ANHYDRIDE;1,3-DIOXOPHTHALAN;1,3-ISOBENZOFURANDIONE;o-phthalic anhydride; Phthalic anhydride 85-44-9 C8H4O3 详情 详情
(III) 10284 N-Phthaloylglycine; 2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)acetic acid 4702-13-0 C10H7NO4 详情 详情
(III) 61589 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetic acid C10H7NO4 详情 详情
(IV) 10278 2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl chloride 6780-38-7 C10H6ClNO3 详情 详情
(IV) 61590 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl chloride C10H6ClNO3 详情 详情
(V) 61591 ethyl 3-iodopropanoate C5H9IO2 详情 详情
(VI) 59167 ethyl 5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-oxopentanoate C15H15NO5 详情 详情
(VI) 61592 ethyl 5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-4-oxopentanoate C15H15NO5 详情 详情
Extended Information