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【结 构 式】 
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【分子编号】51698 【品名】dichloroplatinum diammoniate 【CA登记号】 |
【 分 子 式 】H6Cl2N2Pt 【 分 子 量 】300.04652 【元素组成】H 2.02% Cl 23.63% N 9.34% Pt 65.02% |
合成路线1
该中间体在本合成路线中的序号：(I)The condensation of platinum complex (I) with N-Boc-hexane-1,6-diamine (II) by means of 1 mole of AgNO3 in DMF gives the platinum complex (III), which is deprotected with HCl in methanol/ethanol to yield complex (IV). Finally, platinum complex (I) is condensed with two moles of complex (IV) by means of two moles of AgNO3 in DMF to afford the target trinuclear complex.
| 【1】 Valsecchi, M.; Pavesi, P.; Bugatti, C.; Menta, E.; Giuliani, F.C.; Manzotti, C.; Spinelli, S.; Farrell, N. (Roche Diagnostics GmbH); Trinuclear cationic platinum complexes having antitumour activity and pharmaceutical compsns. containing them. EP 0793667; JP 1998509159; WO 9616068 . |
| 【2】 Valsecchi, M.; Conti, M.; Del Greco, L.; Gubatti, C.; Menta, E.; Giuliani, F.; Manzotti, C.; Spinelli, S.; Farrell, N. (Roche Diagnostics GmbH); Trinuclear cationic platinum complexes having antitumor activity and pharmaceutical compsns. containing them. EP 0753000; JP 1997506633; US 5744497; WO 9526968 . |
合成路线2
该中间体在本合成路线中的序号：(I)The title platinum complex was prepared by treatment of cis-dichlorodiaminoplatinum (I) with potassium ethyl xanthate (II).
| 【1】 Amtmann, E.; Schilling, G. (Deutsches Krebsforschungszentrum; Ruprecht-Karls-Universitat Heidelberg); Medicament containing platinum complex cpds. and the use thereof. WO 0010543 . |
合成路线3
该中间体在本合成路线中的序号：(II)The title compound was obtained by mixing aqueous solutions of sodium cholylglycinate (I) and cis-diamminedichloroplatinum (II) at 80 C.
| 【1】 Criado, J.J.; et al.; Synthesis and characterization of the new cytostatic complex cis-diammineplatinum(II)-chlorocholylglycinate. Bioconjugate Chem 1997, 8, 4, 453. |
合成路线4
该中间体在本合成路线中的序号：(VIII)Substitution of chlorine with iodine in potassium tetrachloroplatinate (I) by treatment with KI in water results in potassium tetraiodoplatinate (II), which by reaction with cyclohexylamine (III) yields cis-di(cyclohexylamine)diiodoplatinium (IV). Reaction of complex (IV) with HClO4 in H2O/EtOH furnishes dimer (V), which is then treated with NH4OH in H2O affording cis-ammine(cyclohexylamine) diiodoplatinium (VI). Nitration of complex (VI) with AgNO3 in H2O followed by chlorination with HCl gives cis-amminechloro-(cyclohexylamine)platinium (VII) . Alternatively, treatment of cisplatin (VIII) with Et4NCl in dimethylacetamide at 100 °C followed by ion exchange by DOWEX 50WX8 and HCl leads to amminetrichloroplatinum (IX), which is then treated with KCl, giving potassium(SP-4-2)-amminetrichloroplatinate (X). Subsequent reaction of compound (X) with cyclohexylamine (III) in the presence of NaI in water furnishes (SP-4-3)-amminechloro(cyclohexanamine)iodoplatinum (XI), which by subsequent nitration and chlorination with AgNO3 in water and treatment with HCl affords complex (VII) . Then, compound (VII) is submitted to hydroxylation with H2O2 in water to give (OC-6-43)-amminedichloro(cyclohexylamine)dihydroxyplatinum (XII), which is finally acetylated with Ac2O in CH2Cl2 .
| 【1】 Khokhar, A.R., Deng, Y., Al-Baker, S., Yoshida, M., Siddik, Z.H. Synthesis and antitumor activity of ammine/amine platinum (II) and (IV) complexes. J Inorg Biochem 1993, 51(3): 677-87. |
| 【2】 Ciandomenico, C.M., Abrams, M.J., Murrer, B.A. et al. Carboxylation of kinetically inert platinum (IV) hydroxy complexes. An entr.acte.ee into orally active platinum (IV) antitumor agents. Inorg Chem 1995, 34(5): 1015-21. |
| 【3】 Abrams, M.J., Giandomenico, C.M., Murrer, B.A., Vollano, J.F. (Johnson Matthey plc). Pt(IV) complexes. AU 8928971, EP 0328274, JP 1989294684. |
| 【4】 Abrams, M.J., Giandomenico, C., Murrer, B.A., Vollano, J.F. (Johnson &Johnson). Pt(IV) complexes. US 5072011. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 51693 | dipotassium tetrachloroplatinate(2-);potassium tetrachloroplatinate(II);potassium tetrachloroplatinate | 10025-99-7 | Cl4K2Pt | 详情 | 详情 |
| (II) | 51694 | dipotassium tetraiodoplatinate(2-);potassium tetraiodoplatinate(II);Potassium tetraiodoplatinate | 14708-56-6 | I4K2Pt | 详情 | 详情 |
| (III) | 17966 | cyclohexanamine; cyclohexyl amine; cyclohexylamine | 108-91-8 | C6H13N | 详情 | 详情 |
| (IV) | 69489 | cis-di(cyclohexylamine)diiodoplatinium | C12H26I2N2Pt | 详情 | 详情 | |
| (V) | 69490 | (cyclohexylamino)platinum(III) iodide | C12H26I4N2Pt2 | 详情 | 详情 | |
| (VI) | 69491 | cis-ammine(cyclohexylamine)diiodoplatinium | C6H16I2N2Pt | 详情 | 详情 | |
| (VII) | 69492 | cis-amminechloro-(cyclohexylamine)platinium | C6H16Cl2N2Pt | 详情 | 详情 | |
| (VIII) | 51698 | dichloroplatinum diammoniate | H6Cl2N2Pt | 详情 | 详情 | |
| (IX) | 69493 | amminetrichloroplatinum | H4Cl3NPt | 详情 | 详情 | |
| (X) | 69494 | potassium (SP-4-2)-amminetrichloroplatinate | H3Cl3KNPt | 详情 | 详情 | |
| (XI) | 69495 | (SP-4-3)-amminechloro(cyclohexanamine)iodoplatinum | C6H16ClIN2Pt | 详情 | 详情 | |
| (XII) | 69496 | (OC-6-43)-amminedichloro(cyclohexylamine)dihydroxyplatinum | C6H18Cl2N2O2Pt | 详情 | 详情 |