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【结 构 式】 
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【分子编号】53507 【品名】 【CA登记号】n/a |
【 分 子 式 】C6H22ClN4Pt 【 分 子 量 】380.80034 【元素组成】C 18.92% H 5.82% Cl 9.31% N 14.71% Pt 51.23% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)The condensation of platinum complex (I) with N-Boc-hexane-1,6-diamine (II) by means of 1 mole of AgNO3 in DMF gives the platinum complex (III), which is deprotected with HCl in methanol/ethanol to yield complex (IV). Finally, platinum complex (I) is condensed with two moles of complex (IV) by means of two moles of AgNO3 in DMF to afford the target trinuclear complex.
| 【1】 Valsecchi, M.; Pavesi, P.; Bugatti, C.; Menta, E.; Giuliani, F.C.; Manzotti, C.; Spinelli, S.; Farrell, N. (Roche Diagnostics GmbH); Trinuclear cationic platinum complexes having antitumour activity and pharmaceutical compsns. containing them. EP 0793667; JP 1998509159; WO 9616068 . |
| 【2】 Valsecchi, M.; Conti, M.; Del Greco, L.; Gubatti, C.; Menta, E.; Giuliani, F.; Manzotti, C.; Spinelli, S.; Farrell, N. (Roche Diagnostics GmbH); Trinuclear cationic platinum complexes having antitumor activity and pharmaceutical compsns. containing them. EP 0753000; JP 1997506633; US 5744497; WO 9526968 . |
Extended Information