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【结 构 式】 
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【药物名称】Tetraplatin tetranitrate, BBR-3464 【化学名称】(trans,trans,trans)-Bis-mu-(hexane-1,6-diamine)-mu-[diammineplatinum(II)]bis[diammine(chloro)platinum(II)] tetranitrate 【CA登记号】172903-00-3, 172902-99-7 (cation) 【 分 子 式 】C12H50Cl2N14O12Pt3 【 分 子 量 】1238.7949 |
【开发单位】Roche (Originator), Novuspharma (Licensee) 【药理作用】Gastric Cancer Therapy, Lung Cancer Therapy, Non-Small Cell Lung Cancer Therapy, Oncolytic Drugs, Ovarian Cancer Therapy, Pancreatic Cancer Therapy, Small Cell Lung Cancer Therapy, Antimitotic Drugs, DNA Alkylating Drugs, Platinum Complexes |
合成路线1
The condensation of platinum complex (I) with N-Boc-hexane-1,6-diamine (II) by means of 1 mole of AgNO3 in DMF gives the platinum complex (III), which is deprotected with HCl in methanol/ethanol to yield complex (IV). Finally, platinum complex (I) is condensed with two moles of complex (IV) by means of two moles of AgNO3 in DMF to afford the target trinuclear complex.
| 【1】 Valsecchi, M.; Pavesi, P.; Bugatti, C.; Menta, E.; Giuliani, F.C.; Manzotti, C.; Spinelli, S.; Farrell, N. (Roche Diagnostics GmbH); Trinuclear cationic platinum complexes having antitumour activity and pharmaceutical compsns. containing them. EP 0793667; JP 1998509159; WO 9616068 . |
| 【2】 Valsecchi, M.; Conti, M.; Del Greco, L.; Gubatti, C.; Menta, E.; Giuliani, F.; Manzotti, C.; Spinelli, S.; Farrell, N. (Roche Diagnostics GmbH); Trinuclear cationic platinum complexes having antitumor activity and pharmaceutical compsns. containing them. EP 0753000; JP 1997506633; US 5744497; WO 9526968 . |