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【结 构 式】 
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【分子编号】52462 【品名】 【CA登记号】 |
【 分 子 式 】C22H24N2O10 【 分 子 量 】476.44004 【元素组成】C 55.46% H 5.08% N 5.88% O 33.58% |
合成路线1
该中间体在本合成路线中的序号：(I)Treatment of 1,2-bis-(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (I) with acetic anhydride and pyridine provided the cyclic anhydride (II). Ethylene glycol octyl ether (V) was prepared by Williamson's synthesis from the sodium alkoxide of ethylene glycol (III) and n-octyl bromide (IV). Finally, the title diester was obtained by heating anhydride (II) with the octyl ether of ethyleneglycol (V).
| 【1】 Kozak, A.; Shapiro, I. (D-Pharm Ltd.); Lipophilic diesters of chelating agents. JP 2001518458; WO 9916741 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 52462 | C22H24N2O10 | 详情 | 详情 | ||
| (II) | 52463 | 4-{2-[(2-{[2-(2,6-dioxo-4-morpholinyl)phenyl]oxy}ethyl)oxy]phenyl}-2,6-morpholinedione | C22H20N2O8 | 详情 | 详情 | |
| (III) | 11295 | Polyethylene glycol;1,2-Ethanediol;Monoethylene glycol; Ethylene glycol | 107-21-1 | C2H6O2 | 详情 | 详情 |
| (IV) | 52464 | Octyl bromide; 1-Octyl bromide; 1-Bromooctane; Capryl bromide; n-Octyl bromide | 111-83-1 | C8H17Br | 详情 | 详情 |
| (V) | 52465 | Ethylene glycol monooctyl ether; n-Octyl-monooxyethylene; Octylglycol | 10020-43-6 | C10H22O2 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(I)Treatment of bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (I) with acetic anhydride in hot pyridine produced the cyclic anhydride (II). Ethyleneglycol mono-ether (V) was prepared by Williamson's synthesis from the sodium alkoxide of ethylene glycol (IV) and octadecyl bromide (III). Then, heating the bis-anhydride (II) with ethyleneglycol monoether (V) produced the title diester
| 【1】 Kozak, A.; Shapiro, I. (D-Pharm Ltd.); Lipophilic diesters of chelating agents. JP 2001518458; WO 9916741 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 52462 | C22H24N2O10 | 详情 | 详情 | ||
| (II) | 52463 | 4-{2-[(2-{[2-(2,6-dioxo-4-morpholinyl)phenyl]oxy}ethyl)oxy]phenyl}-2,6-morpholinedione | C22H20N2O8 | 详情 | 详情 | |
| (III) | 28797 | 1-bromooctadecane | 112-89-0 | C18H37Br | 详情 | 详情 |
| (IV) | 11295 | Polyethylene glycol;1,2-Ethanediol;Monoethylene glycol; Ethylene glycol | 107-21-1 | C2H6O2 | 详情 | 详情 |
| (V) | 53031 | 2-(octadecyloxy)-1-ethanol | n/a | C20H42O2 | 详情 | 详情 |