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【结 构 式】 
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【药物名称】DP-109 【化学名称】2,2'-(Ethylenedioxy)bis(1,2-phenylene)bis[N-[2-[2-(octadecyloxy)ethoxy]-2-oxoethyl]imino]bis(acetic acid) 【CA登记号】347841-31-0 【 分 子 式 】C62H104N2O12 【 分 子 量 】1069.52638 |
【开发单位】D-Pharm (Originator) 【药理作用】Alzheimer's Dementia, Treatment of , Antiparkinsonian Drugs, Cognition Disorders, Treatment of, Extrapyramidal Disorders, Treatment of, NEUROLOGIC DRUGS, Metal Chelators |
合成路线1
Treatment of bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (I) with acetic anhydride in hot pyridine produced the cyclic anhydride (II). Ethyleneglycol mono-ether (V) was prepared by Williamson's synthesis from the sodium alkoxide of ethylene glycol (IV) and octadecyl bromide (III). Then, heating the bis-anhydride (II) with ethyleneglycol monoether (V) produced the title diester
| 【1】 Kozak, A.; Shapiro, I. (D-Pharm Ltd.); Lipophilic diesters of chelating agents. JP 2001518458; WO 9916741 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 52462 | C22H24N2O10 | 详情 | 详情 | ||
| (II) | 52463 | 4-{2-[(2-{[2-(2,6-dioxo-4-morpholinyl)phenyl]oxy}ethyl)oxy]phenyl}-2,6-morpholinedione | C22H20N2O8 | 详情 | 详情 | |
| (III) | 28797 | 1-bromooctadecane | 112-89-0 | C18H37Br | 详情 | 详情 |
| (IV) | 11295 | Polyethylene glycol;1,2-Ethanediol;Monoethylene glycol; Ethylene glycol | 107-21-1 | C2H6O2 | 详情 | 详情 |
| (V) | 53031 | 2-(octadecyloxy)-1-ethanol | n/a | C20H42O2 | 详情 | 详情 |