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【结 构 式】

【药物名称】DP-BAPTA-99, DP-b99

【化学名称】N,N'-[1,2-Ethanediylbis(oxy-2,1-phenylene)]bis[N-(carboxymethyl)glycine] 1,1'-bis[2-(octyloxy)ethyl] ester
      2,2'-(Ethylenedioxy)bis(2,1-phenylene)bis[N-[2-[2-(octyloxy)ethoxy]-2-oxoethyl]imino]bis(acetic acid)

【CA登记号】222315-88-0, 222315-66-4 (diNa salt)

【 分 子 式 】C42H64N2O12

【 分 子 量 】788.98458

【开发单位】D-Pharm (Originator)

【药理作用】Cerebrovascular Diseases, Treatment of, NEUROLOGIC DRUGS, Neurologic Drugs (Miscellaneous), Stroke, Treatment of, Metal Chelators

合成路线1

Treatment of 1,2-bis-(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (I) with acetic anhydride and pyridine provided the cyclic anhydride (II). Ethylene glycol octyl ether (V) was prepared by Williamson's synthesis from the sodium alkoxide of ethylene glycol (III) and n-octyl bromide (IV). Finally, the title diester was obtained by heating anhydride (II) with the octyl ether of ethyleneglycol (V).

1 Kozak, A.; Shapiro, I. (D-Pharm Ltd.); Lipophilic diesters of chelating agents. JP 2001518458; WO 9916741 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 52462   C22H24N2O10 详情 详情
(II) 52463 4-{2-[(2-{[2-(2,6-dioxo-4-morpholinyl)phenyl]oxy}ethyl)oxy]phenyl}-2,6-morpholinedione C22H20N2O8 详情 详情
(III) 11295 Polyethylene glycol;1,2-Ethanediol;Monoethylene glycol; Ethylene glycol 107-21-1 C2H6O2 详情 详情
(IV) 52464 Octyl bromide; 1-Octyl bromide; 1-Bromooctane; Capryl bromide; n-Octyl bromide 111-83-1 C8H17Br 详情 详情
(V) 52465 Ethylene glycol monooctyl ether; n-Octyl-monooxyethylene; Octylglycol 10020-43-6 C10H22O2 详情 详情
Extended Information