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【结 构 式】 
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【分子编号】51315 【品名】tributyl[5-(tributylstannyl)-2-furyl]stannane 【CA登记号】 |
【 分 子 式 】C28H56OSn2 【 分 子 量 】646.17204 【元素组成】C 52.05% H 8.74% O 2.48% Sn 36.74% |
合成路线1
该中间体在本合成路线中的序号：(I)Stille coupling between 2,5-bis(tri-n-butylstannyl)furan (I) and 2-bromo-5-nitroanisole (II) produced the 2,5-bis(4-nitrophenyl)furan (III), which was further reduced to the diamino derivative (IV) by catalytic hydrogenation over Pd/C. The title diamidine was then obtained by reaction of diamine (IV) with the S-(2-naphthylmethyl)thioimidate (V).
| 【1】 Stephens, C.E.; et al.; Diguanidino and " reversed" diamidino 2,5-diaryulfurans as antimicrobial agents. J Med Chem 2001, 44, 11, 1741. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 51315 | tributyl[5-(tributylstannyl)-2-furyl]stannane | C28H56OSn2 | 详情 | 详情 | |
| (II) | 51316 | 2-Bromo-5-nitroanisole | 77337-82-7 | C7H6BrNO3 | 详情 | 详情 |
| (III) | 51317 | 2-[5-(2-methoxy-4-nitrophenyl)-2-furyl]-5-nitrophenyl methyl ether; 2,5-bis(2-methoxy-4-nitrophenyl)furan | C18H14N2O7 | 详情 | 详情 | |
| (IV) | 51318 | 4-[5-(4-amino-2-methoxyphenyl)-2-furyl]-3-methoxyphenylamine; 4-[5-(4-amino-2-methoxyphenyl)-2-furyl]-3-methoxyaniline | C18H18N2O3 | 详情 | 详情 | |
| (V) | 51319 | 2-naphthylmethyl 2-pyridinecarbimidothioate | C17H14N2S | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(I)Stille coupling between 2,5-bis(tri-n-butylstannyl)furan (I) and 2-bromo-5-nitrotoluene (II) produced the 2,5-bis(4-nitrophenyl)furan (III), which was further reduced to the diamino derivative (IV) by catalytic hydrogenation over Pd/C. The title diamidine was then obtained by reaction of diamine (IV) with the (S)-(2-naphthylmethyl)thioimidate (V).
| 【1】 Stephens, C.E.; et al.; Diguanidino and " reversed" diamidino 2,5-diaryulfurans as antimicrobial agents. J Med Chem 2001, 44, 11, 1741. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 51315 | tributyl[5-(tributylstannyl)-2-furyl]stannane | C28H56OSn2 | 详情 | 详情 | |
| (II) | 51320 | 5-Nitro-2-bromotoluene; 2-Bromo-5-nitrotoluene | 7149-70-4 | C7H6BrNO2 | 详情 | 详情 |
| (III) | 51321 | 2,5-bis(2-methyl-4-nitrophenyl)furan | C18H14N2O5 | 详情 | 详情 | |
| (IV) | 51322 | 4-[5-(4-amino-2-methylphenyl)-2-furyl]-3-methylphenylamine; 4-[5-(4-amino-2-methylphenyl)-2-furyl]-3-methylaniline | C18H18N2O | 详情 | 详情 | |
| (V) | 51323 | 2-naphthylmethyl 5-methyl-2-pyridinecarbimidothioate | C18H16N2S | 详情 | 详情 |