【结 构 式】 |
【分子编号】51322 【品名】4-[5-(4-amino-2-methylphenyl)-2-furyl]-3-methylphenylamine; 4-[5-(4-amino-2-methylphenyl)-2-furyl]-3-methylaniline 【CA登记号】 |
【 分 子 式 】C18H18N2O 【 分 子 量 】278.3538 【元素组成】C 77.67% H 6.52% N 10.06% O 5.75% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(IV)Stille coupling between 2,5-bis(tri-n-butylstannyl)furan (I) and 2-bromo-5-nitrotoluene (II) produced the 2,5-bis(4-nitrophenyl)furan (III), which was further reduced to the diamino derivative (IV) by catalytic hydrogenation over Pd/C. The title diamidine was then obtained by reaction of diamine (IV) with the (S)-(2-naphthylmethyl)thioimidate (V).
【1】 Stephens, C.E.; et al.; Diguanidino and " reversed" diamidino 2,5-diaryulfurans as antimicrobial agents. J Med Chem 2001, 44, 11, 1741. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 51315 | tributyl[5-(tributylstannyl)-2-furyl]stannane | C28H56OSn2 | 详情 | 详情 | |
(II) | 51320 | 5-Nitro-2-bromotoluene; 2-Bromo-5-nitrotoluene | 7149-70-4 | C7H6BrNO2 | 详情 | 详情 |
(III) | 51321 | 2,5-bis(2-methyl-4-nitrophenyl)furan | C18H14N2O5 | 详情 | 详情 | |
(IV) | 51322 | 4-[5-(4-amino-2-methylphenyl)-2-furyl]-3-methylphenylamine; 4-[5-(4-amino-2-methylphenyl)-2-furyl]-3-methylaniline | C18H18N2O | 详情 | 详情 | |
(V) | 51323 | 2-naphthylmethyl 5-methyl-2-pyridinecarbimidothioate | C18H16N2S | 详情 | 详情 |
Extended Information