5-Nitro-2-bromotoluene; 2-Bromo-5-nitrotoluene -Drug Synthesis Database

【结构式】

【分子编号】51320

【品名】5-Nitro-2-bromotoluene; 2-Bromo-5-nitrotoluene

【CA登记号】7149-70-4

【分子式】C₇H₆BrNO₂

【分子量】216.03418

【元素组成】C 38.92% H 2.8% Br 36.99% N 6.48% O 14.81%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

Stille coupling between 2,5-bis(tri-n-butylstannyl)furan (I) and 2-bromo-5-nitrotoluene (II) produced the 2,5-bis(4-nitrophenyl)furan (III), which was further reduced to the diamino derivative (IV) by catalytic hydrogenation over Pd/C. The title diamidine was then obtained by reaction of diamine (IV) with the (S)-(2-naphthylmethyl)thioimidate (V).

参考文献中间体

合成目标

【1】 Stephens, C.E.; et al.; Diguanidino and " reversed" diamidino 2,5-diaryulfurans as antimicrobial agents. J Med Chem 2001, 44, 11, 1741.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	51315	tributyl[5-(tributylstannyl)-2-furyl]stannane		C₂₈H₅₆OSn₂	详情	详情
(II)	51320	5-Nitro-2-bromotoluene; 2-Bromo-5-nitrotoluene	7149-70-4	C₇H₆BrNO₂	详情	详情
(III)	51321	2,5-bis(2-methyl-4-nitrophenyl)furan		C₁₈H₁₄N₂O₅	详情	详情
(IV)	51322	4-[5-(4-amino-2-methylphenyl)-2-furyl]-3-methylphenylamine; 4-[5-(4-amino-2-methylphenyl)-2-furyl]-3-methylaniline		C₁₈H₁₈N₂O	详情	详情
(V)	51323	2-naphthylmethyl 5-methyl-2-pyridinecarbimidothioate		C₁₈H₁₆N₂S	详情	详情

Extended Information