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【结 构 式】 
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【药物名称】 【化学名称】N1,N1'-(2,5-Furandiyl)bis(3-methoxy-4,1-phenylene)]bis(pyridine-2-carboxamidine) 【CA登记号】 【 分 子 式 】C30H26N6O3 【 分 子 量 】518.58012 |
【开发单位】Duke University (Originator), Georgia State University (Originator), University of Illinois at Chicago (Originator) 【药理作用】Antifungal Agents, ANTIINFECTIVE THERAPY |
合成路线1
Stille coupling between 2,5-bis(tri-n-butylstannyl)furan (I) and 2-bromo-5-nitroanisole (II) produced the 2,5-bis(4-nitrophenyl)furan (III), which was further reduced to the diamino derivative (IV) by catalytic hydrogenation over Pd/C. The title diamidine was then obtained by reaction of diamine (IV) with the S-(2-naphthylmethyl)thioimidate (V).
| 【1】 Stephens, C.E.; et al.; Diguanidino and " reversed" diamidino 2,5-diaryulfurans as antimicrobial agents. J Med Chem 2001, 44, 11, 1741. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 51315 | tributyl[5-(tributylstannyl)-2-furyl]stannane | C28H56OSn2 | 详情 | 详情 | |
| (II) | 51316 | 2-Bromo-5-nitroanisole | 77337-82-7 | C7H6BrNO3 | 详情 | 详情 |
| (III) | 51317 | 2-[5-(2-methoxy-4-nitrophenyl)-2-furyl]-5-nitrophenyl methyl ether; 2,5-bis(2-methoxy-4-nitrophenyl)furan | C18H14N2O7 | 详情 | 详情 | |
| (IV) | 51318 | 4-[5-(4-amino-2-methoxyphenyl)-2-furyl]-3-methoxyphenylamine; 4-[5-(4-amino-2-methoxyphenyl)-2-furyl]-3-methoxyaniline | C18H18N2O3 | 详情 | 详情 | |
| (V) | 51319 | 2-naphthylmethyl 2-pyridinecarbimidothioate | C17H14N2S | 详情 | 详情 |
Extended Information