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【结 构 式】 
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【分子编号】39983 【品名】3-(trifluoromethyl)phenyl isocyanate; 1-isocyanato-3-(trifluoromethyl)benzene 【CA登记号】329-01-1 |
【 分 子 式 】C8H4F3NO 【 分 子 量 】187.1211096 【元素组成】C 51.35% H 2.15% F 30.46% N 7.49% O 8.55% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(I)The title urea derivative was obtained by condensation of 3-(trifluoromethyl)phenyl isocyanate (I) with anthranilic acid (II).
| 【1】 Baures, P.W.; et al.; Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the non-steroidal anti-inflammatory drug, flufenamic acid. Bioorg Med Chem 2000, 7, 7, 1339. |
| 【2】 Christophersen, P.; Pedersen, O. (NeuroSearch A/S); Phenyl derivs. containing an acidic group, their preparation and their use as chloridic channel blockers. EP 0906273; EP 0977741; JP 2000511167; WO 9745400; WO 9847879 . |
合成路线2
该中间体在本合成路线中的序号：(I)The target compound can be obtained by condensation of 3-trifluoromethylphenyl isocyanate (I) with 5-(2-amino-5-bromophenyl)tetrazole in toluene.
| 【1】 Christophersen, P.; Pedersen, O. (NeuroSearch A/S); Phenyl derivs. containing an acidic group, their preparation and their use as chloridic channel blockers. EP 0906273; EP 0977741; JP 2000511167; WO 9745400; WO 9847879 . |
Extended Information