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【结 构 式】 
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【药物名称】NS-1652 【化学名称】2-[3-[3-(Trifluoromethyl)phenyl]ureido]benzoic acid 【CA登记号】1566-81-0 【 分 子 式 】C15H11F3N2O3 【 分 子 量 】324.26172 |
【开发单位】NeuroSearch (Originator) 【药理作用】Antianemics, HEMATOLOGIC DRUGS, Hematopoiesis Disorders Therapy, Sickle Cell Anemia, Agents for, Chloride Channel Blockers |
合成路线1
The title urea derivative was obtained by condensation of 3-(trifluoromethyl)phenyl isocyanate (I) with anthranilic acid (II).
| 【1】 Baures, P.W.; et al.; Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the non-steroidal anti-inflammatory drug, flufenamic acid. Bioorg Med Chem 2000, 7, 7, 1339. |
| 【2】 Christophersen, P.; Pedersen, O. (NeuroSearch A/S); Phenyl derivs. containing an acidic group, their preparation and their use as chloridic channel blockers. EP 0906273; EP 0977741; JP 2000511167; WO 9745400; WO 9847879 . |
Extended Information