NS-3623, -Drug Synthesis Database

【结构式】

【药物名称】NS-3623

【化学名称】N-[4-Bromo-2-(1H-tetrazol-5-yl)phenyl]-N'-[3-(trifluoromethyl)phenyl]urea

【CA登记号】265646-76-2

【分子式】C₁₅H₁₀BrF₃N₆O

【分子量】427.18575

【开发单位】NeuroSearch (Originator)

【药理作用】Antianemics, HEMATOLOGIC DRUGS, Hematopoiesis Disorders Therapy, Sickle Cell Anemia, Agents for, Chloride Channel Blockers

合成路线1

The target compound can be obtained by condensation of 3-trifluoromethylphenyl isocyanate (I) with 5-(2-amino-5-bromophenyl)tetrazole in toluene.

【1】 Christophersen, P.; Pedersen, O. (NeuroSearch A/S); Phenyl derivs. containing an acidic group, their preparation and their use as chloridic channel blockers. EP 0906273; EP 0977741; JP 2000511167; WO 9745400; WO 9847879 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	39983	3-(trifluoromethyl)phenyl isocyanate; 1-isocyanato-3-(trifluoromethyl)benzene	329-01-1	C₈H₄F₃NO	详情	详情
(II)	50181	4-bromo-2-(1H-1,2,3,4-tetraazol-5-yl)phenylamine; 4-bromo-2-(1H-1,2,3,4-tetraazol-5-yl)aniline		C₇H₆BrN₅	详情	详情

Extended Information