4-bromo-2-(1H-1,2,3,4-tetraazol-5-yl)phenylamine; 4-bromo-2-(1H-1,2,3,4-tetraazol-5-yl)aniline -Drug Synthesis Database

【结构式】

【分子编号】50181

【品名】4-bromo-2-(1H-1,2,3,4-tetraazol-5-yl)phenylamine; 4-bromo-2-(1H-1,2,3,4-tetraazol-5-yl)aniline

【CA登记号】

【分子式】C₇H₆BrN₅

【分子量】240.06234

【元素组成】C 35.02% H 2.52% Br 33.28% N 29.17%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The target compound can be obtained by condensation of 3-trifluoromethylphenyl isocyanate (I) with 5-(2-amino-5-bromophenyl)tetrazole in toluene.

【1】 Christophersen, P.; Pedersen, O. (NeuroSearch A/S); Phenyl derivs. containing an acidic group, their preparation and their use as chloridic channel blockers. EP 0906273; EP 0977741; JP 2000511167; WO 9745400; WO 9847879 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	39983	3-(trifluoromethyl)phenyl isocyanate; 1-isocyanato-3-(trifluoromethyl)benzene	329-01-1	C₈H₄F₃NO	详情	详情
(II)	50181	4-bromo-2-(1H-1,2,3,4-tetraazol-5-yl)phenylamine; 4-bromo-2-(1H-1,2,3,4-tetraazol-5-yl)aniline		C₇H₆BrN₅	详情	详情

Extended Information