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【结 构 式】 
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【分子编号】41900 【品名】5-methyl-2,4-bis[(trimethylsilyl)oxy]pyrimidine; 5-methyl-2-[(trimethylsilyl)oxy]-4-pyrimidinyl trimethylsilyl ether 【CA登记号】7288-28-0 |
【 分 子 式 】C11H22N2O2Si2 【 分 子 量 】270.47896 【元素组成】C 48.85% H 8.2% N 10.36% O 11.83% Si 20.77% |
合成路线1
该中间体在本合成路线中的序号：(IV)The reaction of 1,3,5-tri-O-benzoyl-2-O-(trifluoromethanesulfonyl)-alpha-D-ribofuranose (I) with labeled tetrabutylammonium fluoride in acetonitrile gives 1,3,5-tri-O-benzoyl-2-deoxy-2-fluoro-alpha-D-arabinofuranose (II), which is treated with HBr/HOAc in dichloroethane to yield 3,5-di-O-benzoyl-2-deoxy-2-fluoro-alpha-D-arabinofuranosyl bromide (III). The condensation of (III) with thymine bis trimethylsilyl ether (IV) in dichloroethane affords a mixture of protected nucleoside alpha and beta anomers (V) and (VI), which, without separation, is deprotected with NaOMe in methanol and submitted to HPLC chromatographic separation to provide the target unprotected and labeled beta anomer.
| 【1】 Alauddin, M.M.; et al.; Synthesis of [18F]-labeled 2'-deoxy-2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil ([18F]-FMAU). J Label Compd Radiopharm 2002, 45, 7, 583. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 56869 | (2R,3R,4R,5R)-4-(benzoyloxy)-5-[(benzoyloxy)methyl]-3-{[(trifluoromethyl)sulfonyl]oxy}tetrahydro-2-furanyl benzoate | C27H21F3O10S | 详情 | 详情 | |
| (II) | 17698 | [(2R,3R,4S,5R)-3,5-bis(benzoyloxy)-4-fluorotetrahydro-2-furanyl]methyl benzoate | C26H21FO7 | 详情 | 详情 | |
| (II) | 56870 | (2R,3S,4R,5R)-4-(benzoyloxy)-5-[(benzoyloxy)methyl]-3-fluorotetrahydro-2-furanyl benzoate | C26H21FO7 | 详情 | 详情 | |
| (III) | 17524 | [(2S,3S,4R,5S)-3-(benzoyloxy)-5-bromo-4-fluorotetrahydro-2-furanyl]methyl benzoate | C19H16BrFO5 | 详情 | 详情 | |
| (III) | 56871 | (2R,3R,4S,5R)-2-[(benzoyloxy)methyl]-5-bromo-4-fluorotetrahydro-3-furanyl benzoate | C19H16BrFO5 | 详情 | 详情 | |
| (IV) | 41900 | 5-methyl-2,4-bis[(trimethylsilyl)oxy]pyrimidine; 5-methyl-2-[(trimethylsilyl)oxy]-4-pyrimidinyl trimethylsilyl ether | 7288-28-0 | C11H22N2O2Si2 | 详情 | 详情 |
| (V) | 56872 | (2R,3R,4S,5S)-2-[(benzoyloxy)methyl]-4-fluoro-5-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-3-furanyl benzoate | C24H21FN2O7 | 详情 | 详情 | |
| (V) | 56874 | (2R,3R,4S,5S)-2-[(benzoyloxy)methyl]-4-fluoro-5-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-3-furanyl benzoate | C24H21FN2O7 | 详情 | 详情 | |
| (VI) | 56873 | (2R,3R,4S,5R)-2-[(benzoyloxy)methyl]-4-fluoro-5-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-3-furanyl benzoate | C24H21FN2O7 | 详情 | 详情 | |
| (VI) | 56875 | (2R,3R,4S,5R)-2-[(benzoyloxy)methyl]-4-fluoro-5-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-3-furanyl benzoate | C24H21FN2O7 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(V)The reaction of 2-deoxy-D-ribose (I) with MeOH and HCl gives the methylglycoside (II), which is selectively silylated with TBDPSCl and DMAP in pyridine to yield the monosilylated glycoside (III). The reaction of (III) with TsCl in pyridine affords the 3'-tosylate (IV), which is condensed with the bis(trimethylsilyl)thymine (VI) by means of TMS-OTf in MeCN to provide 5'-O-(tert-butydiphenylsilyl)-3'-O-tosylthymidine (VII). Finally this compound is treated with TBAF in refluxing THF.
| 【1】 Kofoed, T.; Larsen, E.; Pedersen, E.B.; Synthesis of 2',3'-anhydro-2'-deoxyuridines and 2',3'-didehydro-2',3'-dideoxyuridines using polymer supported fluoride. Synthesis 1995, 1121. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 41897 | (4S,5R)tetrahydro-2H-pyran-2,4,5-triol | 35536-75-5 | C5H10O4 | 详情 | 详情 |
| (II) | 12241 | (2R,3S)-2-(Hydroxymethyl)-5-methoxytetrahydro-3-furanol | C6H12O4 | 详情 | 详情 | |
| (III) | 41898 | (2R,3S)-2-([[tert-butyl(diphenyl)silyl]oxy]methyl)-5-methoxytetrahydro-3-furanol | C22H30O4Si | 详情 | 详情 | |
| (IV) | 41899 | (2R,3S)-2-([[tert-butyl(diphenyl)silyl]oxy]methyl)-5-methoxytetrahydro-3-furanyl 4-methylbenzenesulfonate | C29H36O6SSi | 详情 | 详情 | |
| (V) | 41900 | 5-methyl-2,4-bis[(trimethylsilyl)oxy]pyrimidine; 5-methyl-2-[(trimethylsilyl)oxy]-4-pyrimidinyl trimethylsilyl ether | 7288-28-0 | C11H22N2O2Si2 | 详情 | 详情 |
| (VI) | 41901 | (2R,3S,5R)-2-([[tert-butyl(diphenyl)silyl]oxy]methyl)-5-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-3-furanyl 4-methylbenzenesulfonate | C33H38N2O7SSi | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(V)Finally this compound can be deprotected by conventional methods: (a) The acylation of 1,2-O-isopropylidene-alpha-D-xylofuranose (I) with benzoyl chloride and pyridine gives the 5-O-benzoyl derivative (II), which is acylated again with Ac2O in pyridine to yield the 3-O-acetyl-5-O-benzoyl derivative (III). The reaction of (III) with Ac2O in acetic acid affords the triacetyl derivative (IV) which is condensed with fully silylated thymine (V) by means of SnCl4 in acetone to provide the corresponding adduct (VI). The selective hydrolysis of the acetate groups of (VI) with sulfuric acid in hot acetonitrile gives 1-(5-O-benzoyl-beta-D-xylofuranosyl)thymine (VII), which is treated with MsCl and pyridine to yield the dimesylate (VIII). The reaction of (VIII) with NaI in refluxing dimethoxyethane affords, after column chromatography, 5'-O-benzoyl-3'-deoxy-2',3'-dideoxythymidine (IX), which is finally deprotected with NaOMe in methanol. (b) The reaction of the 5-O-benzoyl derivative (II) with MsCl and pyridine gives the mesylate (X), which is acylated with Ac2O in HOAc to yield 1,2-di-O-acetyl-5-O-benzoyl-3-O-(methylsulfonyl)-alpha-D-xylofuranose (XI). The condensation of (XI) with the fully silylated thymine (V) by means of SnCl4 in acetone affords the expected adduct (XII), which is treated with H2SO4 in hot MeCN to provide 1-(5'-O-benzoyl-3'-O-(methylsulfonyl)-beta-D-xylofuranosyl)thymine (XIII). Finally this compound is treated with MsCl and pyridine to yield the dimesylate (VIII), already reported. (c) The 1-(5-O-benzoyl-beta-D-xylofuranosyl)thymine (VII) can also be treated with TsCl and pyridine to give the ditosylate (XIV), which is then treated with NaI in refluxing dimethoxyethane to yield 5'-O-benzoyl-3'-deoxy-2',3'-dideoxythymidine (IX), already reported.
| 【1】 Spirikhin, L.V.; Mustafin, A.G.; Tolstikov, G.A.; Abdrakhumanov, L.B.; Gataullin, R.R.; Transformations of beta-D-xylofuranosyl nucleosides. Synthesis of 3'-deoxy-2,3-didehydrothymidine (D4T). Russian J Org Chem 1996, 32, 12, 1787. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 41907 | (3aR,5R,6S,6aR)-5-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-6-ol | 20031-21-4 | C8H14O5 | 详情 | 详情 |
| (II) | 41908 | [(3aR,5R,6S,6aR)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl]methyl benzoate | C15H18O6 | 详情 | 详情 | |
| (III) | 41909 | [(3aR,5R,6S,6aR)-6-(acetoxy)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl]methyl benzoate | C17H20O7 | 详情 | 详情 | |
| (IV) | 41910 | [(2R,3S,4R,5R)-3,4,5-tris(acetoxy)tetrahydro-2-furanyl]methyl benzoate | C18H20O9 | 详情 | 详情 | |
| (V) | 41900 | 5-methyl-2,4-bis[(trimethylsilyl)oxy]pyrimidine; 5-methyl-2-[(trimethylsilyl)oxy]-4-pyrimidinyl trimethylsilyl ether | 7288-28-0 | C11H22N2O2Si2 | 详情 | 详情 |
| (VI) | 41911 | [(2R,3S,4R,5R)-3,4-bis(acetoxy)-5-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-2-furanyl]methyl benzoate | C21H22N2O9 | 详情 | 详情 | |
| (VII) | 41912 | [(2R,3R,4R,5R)-3,4-dihydroxy-5-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-2-furanyl]methyl benzoate | C17H18N2O7 | 详情 | 详情 | |
| (VIII) | 41913 | [(2R,3S,4R,5R)-3,4-bis[[methyl(dimethylene)-lambda(6)-sulfanyl]oxy]-5-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-2-furanyl]methyl benzoate | C23H30N2O7S2 | 详情 | 详情 | |
| (IX) | 12254 | [(2S,5R)-5-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]-2,5-dihydro-2-furanyl]methyl benzoate | C17H16N2O5 | 详情 | 详情 | |
| (X) | 41914 | ((3aR,5R,6S,6aR)-2,2-dimethyl-6-[[methyl(dimethylene)-lambda(6)-sulfanyl]oxy]tetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methyl benzoate | C18H24O6S | 详情 | 详情 | |
| (XI) | 41915 | ((2R,3S,4R,5R)-4,5-bis(acetoxy)-3-[[methyl(dimethylene)-lambda(6)-sulfanyl]oxy]tetrahydro-2-furanyl)methyl benzoate | C19H24O8S | 详情 | 详情 | |
| (XII) | 41916 | [(2R,3S,4R,5R)-4-(acetoxy)-3-[[methyl(dimethylene)-lambda(6)-sulfanyl]oxy]-5-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-2-furanyl]methyl benzoate | C22H26N2O8S | 详情 | 详情 | |
| (XIII) | 41917 | [(2R,3R,4R,5R)-4-hydroxy-3-[[methyl(dimethylene)-lambda(6)-sulfanyl]oxy]-5-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-2-furanyl]methyl benzoate | C20H24N2O7S | 详情 | 详情 | |
| (XIV) | 41918 | ((2R,3S,4R,5R)-5-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]-3,4-bis[[(4-methylphenyl)sulfonyl]oxy]tetrahydro-2-furanyl)methyl benzoate | C31H30N2O11S2 | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：(VI)The reaction of gamma-lactone (I) with N-(phenylsulfanyl)phthalimide (II) by means of LiHMDS in THF gives the 2,2-bis(phenylsulfanyl)lactone (III), which is reduced with DIBAL in THF to yield 5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2,2-bis(phenylsulfanyl)-D-ribose (IV). The reaction of (IV) with acetic anhydride affords the acetylated ribose (V), which is condensed with bis(trimethylsilyl)thymine (VI) by means of TMS-OTf in acetonitrile to provide the glycosylated thymine (VII). The oxidation of (VII) with 1 mol of MCPBA in dichloromethane gives the sulfinyl compound (VIII), which is treated with tributylamine in refluxing xylene to yield the 2',3'-didehydro compound (IX). The oxidation of (IX) with MCPBA in dichloromethane gives the phenylsulfonyl derivative (X), which is desulfurized with sodium amalgam in methanol, yielding the silylated intermediate (XI). Finally, this compound is desilylated with TBAF in THF.
| 【1】 Kawakami, H.; et al.; Condensation reaction between 2,2-diphenylthio-2,3-dideoxyriboside and silyvated pyrimidine bases. Nucleosides Nucleotides 1992, 11, 9, 1673. |
| 【2】 Ebata, T.; Matsushita, H.; Kuno, H.; Niihata, S.; Synthesis of 2',3'-didehydro-2',3'-dideoxy nucleosides from 2',2'-bis (phenylthio) nucleoside analogs. Bull Chem Soc Jpn 1995, 68, 8, 2327. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 12215 | (5S)-5-([[tert-Butyl(diphenyl)silyl]oxy]methyl)dihydro-2(3H)-furanone | C21H26O3Si | 详情 | 详情 | |
| (II) | 42577 | 2-(phenylsulfanyl)-1H-isoindole-1,3(2H)-dione | 14204-27-4 | C14H9NO2S | 详情 | 详情 |
| (III) | 42578 | (5S)-5-([[tert-butyl(diphenyl)silyl]oxy]methyl)-3,3-bis(phenylsulfanyl)dihydro-2(3H)-furanone | C33H34O3S2Si | 详情 | 详情 | |
| (IV) | 42579 | (5S)-5-([[tert-butyl(diphenyl)silyl]oxy]methyl)-3,3-bis(phenylsulfanyl)tetrahydro-2-furanol | C33H36O3S2Si | 详情 | 详情 | |
| (V) | 42580 | (5S)-5-([[tert-butyl(diphenyl)silyl]oxy]methyl)-3,3-bis(phenylsulfanyl)tetrahydro-2-furanyl acetate | C35H38O4S2Si | 详情 | 详情 | |
| (VI) | 41900 | 5-methyl-2,4-bis[(trimethylsilyl)oxy]pyrimidine; 5-methyl-2-[(trimethylsilyl)oxy]-4-pyrimidinyl trimethylsilyl ether | 7288-28-0 | C11H22N2O2Si2 | 详情 | 详情 |
| (VII) | 42584 | 1-[(2S,5S)-5-([[tert-butyl(diphenyl)silyl]oxy]methyl)-3,3-bis(phenylsulfanyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione | C38H40N2O4S2Si | 详情 | 详情 | |
| (VIII) | 42581 | 1-[(2R,5S)-5-([[tert-butyl(diphenyl)silyl]oxy]methyl)-3-(phenylsulfanyl)-3-(phenylsulfinyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione | C38H40N2O5S2Si | 详情 | 详情 | |
| (IX) | 42582 | 1-[(2R,5S)-5-([[tert-butyl(diphenyl)silyl]oxy]methyl)-3-(phenylsulfanyl)-2,5-dihydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione | C32H34N2O4SSi | 详情 | 详情 | |
| (X) | 42583 | 1-[(2R,5S)-5-([[tert-butyl(diphenyl)silyl]oxy]methyl)-3-(phenylsulfonyl)-2,5-dihydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione | C32H34N2O6SSi | 详情 | 详情 | |
| (XI) | 12223 | 1-[(2R,5S)-5-([[tert-Butyl(diphenyl)silyl]oxy]methyl)-2,5-dihydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione | C26H30N2O4Si | 详情 | 详情 |
合成路线5
该中间体在本合成路线中的序号：(X)A new synthesis of clevudine has been described: Peracetylation of L-arabinose (I) with acetic anhydride and pyridine provides acetylated arabinose (II), which is then brominated by means of HBr in AcOH/Ac2O to furnish the bromo-sugar (III). Treatment of the sugar (III) with Zn dust, CuSO4 and NaOAc in AcOH/H2O, followed by chromatographic separation, gives L-arabinal (IV), which is then converted to the fluoro derivative (V) by reaction with Selectfluor?(F-TEDA-BF4) in refluxing nitromethane/H2O. Deacetylation of compound (V) with NaOMe in MeOH yields compound (VI), which is then converted into the methyl furanoside (VII) by treatment with H2SO4 in MeOH. Benzoylation of the furanoside (VII) with benzoyl chloride in pyridine affords a mixture of isomers, from which (VIII) is separated by chromatography and then brominated with HBr/AcOH in CH2Cl2 to provide the bromo-sugar (IX). Condensation of the sugar (IX) with the silylated pyrimidine derivative (X) in refluxing chloroform affords 3,5-di-O-benzoylclevudine (XI), which is finally deprotected by treatment with n-butylamine in refluxing methanol. Compound (X) is obtained by treatment of thymine (XII) with HMDS (1,1,1,3,3,3-hexamethyldisilazane) and ammonium sulfate in refluxing chloroform.
| 【1】 Almond, M.R.; Pesyan, A.; Sznaidman, M.L.; New synthesis of L-FMAU from L-arabinose. Nucleosides Nucleotides Nucleic Acids 2002, 21, 2, 155. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 17520 | (3R,4S,5S)tetrahydro-2H-pyran-2,3,4,5-tetrol; L-(+)-Arabinose | 7296-56-2 | C5H10O5 | 详情 | 详情 |
| (II) | 48936 | D-Arabinose tetraacetate | C13H18O9 | 详情 | 详情 | |
| (III) | 54161 | (2R,3R,4S,5S)-3,5-bis(acetyloxy)-2-bromotetrahydro-2H-pyran-4-yl acetate | n/a | C11H15BrO7 | 详情 | 详情 |
| (IV) | 54162 | (3S,4R)-3-(acetyloxy)-3,4-dihydro-2H-pyran-4-yl acetate | n/a | C9H12O5 | 详情 | 详情 |
| (V) | 54163 | (3R,4S,5S)-5-(acetyloxy)-3-fluoro-2-hydroxytetrahydro-2H-pyran-4-yl acetate | n/a | C9H13FO6 | 详情 | 详情 |
| (VI) | 54164 | (3R,4S,5S)-3-fluorotetrahydro-2H-pyran-2,4,5-triol | n/a | C5H9FO4 | 详情 | 详情 |
| (VII) | 54167 | (2S,3S,4R)-4-fluoro-2-(hydroxymethyl)-5-methoxytetrahydro-3-furanol | n/a | C6H11FO4 | 详情 | 详情 |
| (VIII) | 54165 | [(2S,3S,4R,5R)-3-(benzoyloxy)-4-fluoro-5-methoxytetrahydro-2-furanyl]methyl benzoate | n/a | C20H19FO6 | 详情 | 详情 |
| (IX) | 17524 | [(2S,3S,4R,5S)-3-(benzoyloxy)-5-bromo-4-fluorotetrahydro-2-furanyl]methyl benzoate | C19H16BrFO5 | 详情 | 详情 | |
| (X) | 41900 | 5-methyl-2,4-bis[(trimethylsilyl)oxy]pyrimidine; 5-methyl-2-[(trimethylsilyl)oxy]-4-pyrimidinyl trimethylsilyl ether | 7288-28-0 | C11H22N2O2Si2 | 详情 | 详情 |
| (XI) | 54166 | {(2S,3S,4R,5S)-3-(benzoyloxy)-4-fluoro-5-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-2-furanyl}methyl benzoate | n/a | C24H21FN2O7 | 详情 | 详情 |
| (XII) | 12204 | 5-Methyl-2,4(1H,3H)-pyrimidinedione; Thymine | 65-71-4 | C5H6N2O2 | 详情 | 详情 |
合成路线6
该中间体在本合成路线中的序号：(XIV)2-Deoxy-L-ribose (VI) is converted into 1-chloro-1,2-dideoxy-3,5-di-O-p-toluoyl-L-ribose (X) by using Hoffer's method for the D-enantiomer. Treatment of 2-deoxy-L-ribose with MeOH in HCl/MeOH provides methyl 2-deoxy-L-riboside (XIII), which is condensed with p-toluoyl chloride by means of KHCO3 in pyridine to give methyl 2-deoxy-3,5-di-O-p-toluoyl-L-riboside (VII). Chlori-nation of riboside (VII) with glacial AcOH and HCl affords 1-chloro-1,2-dideoxy-3,5-di-O-p-toluoyl-L-ribose (X), which is condensed with 5-methyl-2,4-bis(trimethylsilyl-oxy)pyrimidine (XIV) by means of p-nitrophenol in chloroform to yield the protected thymidine (XII). Finally, this compound is deprotected by means of NH3 in methanol.
| 【1】 Fujimori, S.; Iwanami, N.; Hashimoto, Y.; Shudo, K.; A convenient and stereoselective synthesis of 2'-deoxy-beta-L-ribonucleosides. Nucleosides Nucleotides 1992, 11, 2-4, 341. |
| 【2】 Sorbera, L.A.; Castañer, J.; Castañer, R.M.; Bayes, M.; Telbivudine. Drugs Fut 2003, 28, 9, 870. |
| 【3】 Hoffer, M.; alpha-Thymidine. Chem Ber 1960, 93, 2777. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VI) | 62914 | (4R,5S)-5-(hydroxymethyl)tetrahydro-2,4-furandiol | C5H10O4 | 详情 | 详情 | |
| (VII) | 62915 | {(2S,3R)-5-methoxy-3-[(4-methylbenzoyl)oxy]tetrahydro-2-furanyl}methyl 4-methylbenzoate | C22H24O6 | 详情 | 详情 | |
| (X) | 37194 | (2R,3S)-5-Chloro-2-[[(4-methylbenzoyl)oxy]methyl]tetrahydro-3-furanyl 4-methylbenzoate | 4330-21-6 | C21H21ClO5 | 详情 | 详情 |
| (XII) | 62918 | {(2S,3R,5S)-3-[(4-methylbenzoyl)oxy]-5-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-2-furanyl}methyl 4-methylbenzoate | C26H26N2O7 | 详情 | 详情 | |
| (XIII) | 12241 | (2R,3S)-2-(Hydroxymethyl)-5-methoxytetrahydro-3-furanol | C6H12O4 | 详情 | 详情 | |
| (XIV) | 41900 | 5-methyl-2,4-bis[(trimethylsilyl)oxy]pyrimidine; 5-methyl-2-[(trimethylsilyl)oxy]-4-pyrimidinyl trimethylsilyl ether | 7288-28-0 | C11H22N2O2Si2 | 详情 | 详情 |