【结 构 式】 |
【分子编号】34006 【品名】1-(2-chlorophenyl)-1-ethanone 【CA登记号】2142-68-9 |
【 分 子 式 】C8H7ClO 【 分 子 量 】154.59568 【元素组成】C 62.15% H 4.56% Cl 22.93% O 10.35% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号:(I)The oxidation of 2-chloroacetophenone (I) with SeO2 in dioxane-water gives 2-chlorophenylglyoxal (II), b.p. 87-90 C/1 mm, which is then reductocondensed with tert-butylamine (III) and NaSH4 in ethanol.
【1】 Kato, H.; Kurata, S.; Verfahren zur Herstellung con Derivaten des Chlorbenzylalkohols. BE 0788737; DE 2244737; ES 406646; FR 2154082; JP 48034848 . |
【2】 Castaner, J.; Thorpe, P.; C 78. Drugs Fut 1976, 1, 5, 217. |
合成路线2
该中间体在本合成路线中的序号:(II)The reaction of 2,4-dichlorophenol (I) with 2-chloroacetophenone (II) by means of a copper catalyst and sodium hydroxide gives 2-(2,4-dichlorophenoxy)acetophenone (III), which is treated with sulfur in refluxing morpholine yielding 2-(2,4-dichlorophenoxy)phenylthioacetomorpholide (IV). Finally, this compound is hydrolyzed with KOH in refluxing methanol.
【1】 Arrigoni-Martelli, E.; Castañer, J.; Fenclofenac. Drugs Fut 1977, 2, 10, 665. |
【2】 Godfrey, K.E. (Reckitt & Colman Pharmaceuticals); Substituted 2-phenoxyphenylacetic acids. DE 2117826; FR 2092044; GB 1308327; US 3766263 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
10388 | Morpholine | 110-91-8 | C4H9NO | 详情 | 详情 | |
(I) | 40047 | 2,4-dichlorophenol | 120-83-2 | C6H4Cl2O | 详情 | 详情 |
(II) | 34006 | 1-(2-chlorophenyl)-1-ethanone | 2142-68-9 | C8H7ClO | 详情 | 详情 |
(III) | 40172 | 1-[2-(2,4-dichlorophenoxy)phenyl]-1-ethanone | C14H10Cl2O2 | 详情 | 详情 | |
(IV) | 40173 | 2-[2-(2,4-dichlorophenoxy)phenyl]-1-(4-morpholinyl)-1-ethanethione | C18H17Cl2NO2S | 详情 | 详情 |
Extended Information