2-[2-(2,4-dichlorophenoxy)phenyl]-1-(4-morpholinyl)-1-ethanethione -Drug Synthesis Database

【结构式】

【分子编号】40173

【品名】2-[2-(2,4-dichlorophenoxy)phenyl]-1-(4-morpholinyl)-1-ethanethione

【CA登记号】

【分子式】C₁₈H₁₇Cl₂NO₂S

【分子量】382.30992

【元素组成】C 56.55% H 4.48% Cl 18.55% N 3.66% O 8.37% S 8.39%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

The reaction of 2,4-dichlorophenol (I) with 2-chloroacetophenone (II) by means of a copper catalyst and sodium hydroxide gives 2-(2,4-dichlorophenoxy)acetophenone (III), which is treated with sulfur in refluxing morpholine yielding 2-(2,4-dichlorophenoxy)phenylthioacetomorpholide (IV). Finally, this compound is hydrolyzed with KOH in refluxing methanol.

参考文献中间体

合成目标

【1】 Arrigoni-Martelli, E.; Castañer, J.; Fenclofenac. Drugs Fut 1977, 2, 10, 665.
【2】 Godfrey, K.E. (Reckitt & Colman Pharmaceuticals); Substituted 2-phenoxyphenylacetic acids. DE 2117826; FR 2092044; GB 1308327; US 3766263 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
	10388	Morpholine	110-91-8	C₄H₉NO	详情	详情
(I)	40047	2,4-dichlorophenol	120-83-2	C₆H₄Cl₂O	详情	详情
(II)	34006	1-(2-chlorophenyl)-1-ethanone	2142-68-9	C₈H₇ClO	详情	详情
(III)	40172	1-[2-(2,4-dichlorophenoxy)phenyl]-1-ethanone		C₁₄H₁₀Cl₂O₂	详情	详情
(IV)	40173	2-[2-(2,4-dichlorophenoxy)phenyl]-1-(4-morpholinyl)-1-ethanethione		C₁₈H₁₇Cl₂NO₂S	详情	详情

Extended Information