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【结 构 式】 
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【药物名称】Fenclofenac, R-67408, Rx-67408 【化学名称】2-[2-(2,4-Dichlorophenoxy)phenyl]acetic acid 【CA登记号】34645-84-6 【 分 子 式 】C14H10Cl2O3 【 分 子 量 】297.14 |
【开发单位】 【药理作用】 |
合成路线1
The reaction of 2,4-dichlorophenol (I) with 2-chloroacetophenone (II) by means of a copper catalyst and sodium hydroxide gives 2-(2,4-dichlorophenoxy)acetophenone (III), which is treated with sulfur in refluxing morpholine yielding 2-(2,4-dichlorophenoxy)phenylthioacetomorpholide (IV). Finally, this compound is hydrolyzed with KOH in refluxing methanol.
| 【1】 Arrigoni-Martelli, E.; Castañer, J.; Fenclofenac. Drugs Fut 1977, 2, 10, 665. |
| 【2】 Godfrey, K.E. (Reckitt & Colman Pharmaceuticals); Substituted 2-phenoxyphenylacetic acids. DE 2117826; FR 2092044; GB 1308327; US 3766263 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 10388 | Morpholine | 110-91-8 | C4H9NO | 详情 | 详情 | |
| (I) | 40047 | 2,4-dichlorophenol | 120-83-2 | C6H4Cl2O | 详情 | 详情 |
| (II) | 34006 | 1-(2-chlorophenyl)-1-ethanone | 2142-68-9 | C8H7ClO | 详情 | 详情 |
| (III) | 40172 | 1-[2-(2,4-dichlorophenoxy)phenyl]-1-ethanone | C14H10Cl2O2 | 详情 | 详情 | |
| (IV) | 40173 | 2-[2-(2,4-dichlorophenoxy)phenyl]-1-(4-morpholinyl)-1-ethanethione | C18H17Cl2NO2S | 详情 | 详情 |
Extended Information