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【结 构 式】 
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【分子编号】32359 【品名】dimethyl phosphonate 【CA登记号】868-85-9 |
【 分 子 式 】C2H7O3P 【 分 子 量 】110.049542 【元素组成】C 21.83% H 6.41% O 43.62% P 28.15% |
合成路线1
该中间体在本合成路线中的序号：(B)The reaction of chlorobenzoyl chloride (I) with trimethyl phosphite gives dimethyl p-chlorobenzoylphosphonate (II). Addition of dimethyl phosphite to (II) in the presence of 80% molar amount of an organic base (e.g., di-n-butylamine) in diethyl ether or toluene at 0 C produces the final compound.
| 【1】 Bentzen, C.L.; Nguyen, M.L.; Niesor, E.; US 4309364 . |
| 【2】 Nguyen, M.L.; Bentzen, C.L.; SR-202. Drugs Fut 1982, 7, 4, 271. |
合成路线2
该中间体在本合成路线中的序号：(IX)Improved large scale synthesis: The formylation of 1,4-dimethoxybenzene (I) with C6H11-Li, TMEDA and DMF gives 2,5-dimethoxybenzaldehyde (II), which is reduced with NaBH4 in toluene/methanol to the corresponding alcohol (III). The treatment of (III) with PBr3 in ethyl acetate affords the benzyl bromide (IV), which by reaction with dimethyl phosphite (IX) and NaH in toluene is converted into the phosphonate (X). The condensation of (X) with 5-formyl-2-hydroxybenzoic acid methyl ester (VI)(obtained by esterification of the corresponding acid (VII) with methanol and H2SO4) by means of LiHMDS in THF affords the stilbene (VIII). Finally, this compound is reduced with H2 over Pd/C in ethyl acetate.
| 【1】 Kucerovy, A.; et al.; An efficient large-scale synthesis of methyl 5-[2-82,5-dimethoxyphenyl)ethyl]-2-hydroxybenzoate. Org Process Res Dev 1997, 1, 4, 287. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 21946 | 1,4-dimethoxybenzene; 4-methoxyphenyl methyl ether | 150-78-7 | C8H10O2 | 详情 | 详情 |
| (II) | 10174 | 2,5-Dimethoxybenzaldehyde | 93-02-7 | C9H10O3 | 详情 | 详情 |
| (III) | 32353 | (2,5-dimethoxyphenyl)methanol | 33524-31-1 | C9H12O3 | 详情 | 详情 |
| (IV) | 32354 | 2-(bromomethyl)-4-methoxyphenyl methyl ether; 2-(bromomethyl)-1,4-dimethoxybenzene | C9H11BrO2 | 详情 | 详情 | |
| (VI) | 32356 | methyl 5-formyl-2-hydroxybenzoate | C9H8O4 | 详情 | 详情 | |
| (VII) | 32357 | 5-Formylsalicylic acid; 5-formyl-2-hydroxybenzoic acid | 616-76-2 | C8H6O4 | 详情 | 详情 |
| (VIII) | 32358 | methyl 5-[(E)-2-(2,5-dimethoxyphenyl)ethenyl]-2-hydroxybenzoate | C18H18O5 | 详情 | 详情 | |
| (IX) | 32359 | dimethyl phosphonate | 868-85-9 | C2H7O3P | 详情 | 详情 |
| (X) | 32360 | dimethyl 2,5-dimethoxybenzylphosphonate | C11H17O5P | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(XI)Treatment of diamino compound (I) with oxalic acid (II) in refluxing HCl provides tetrahydroquinoxalindione derivative (III), which is then converted into dichloro compound (IV) by reaction with refluxing POCl3. Treatment of (IV) with Na in refluxing MeOH affords dimethoxy quinoxaline (V), which is then brominated by reaction with NBS and AIBN in refluxing CCl4 to give bromomethyl derivative (VI). Nitration of (VI) by reaction with isopropyl nitrate in H2SO4 yields nitro derivative (VII), which is then converted into protected amino methyl derivative (IX) by reaction with di-tert-butyl-iminocarboxylate (VIII) and cesium carbonate in DMF. Removal of the Boc groups of (IX) by means of TFA gives aminomethyl derivative (X), which is then converted into phosphonic dimethyl ester (XII) by first treatment with formaline in EtOH followed by reaction with dimethyl phosphonate (XI), Et3N and trimethylsilyl chloride (TMSCl) in CHCl3. Finally, treatment of (XII) with trimethylsilyl bromide (TMSBr) in CH2Cl2 obtains the desired product.
| 【1】 Acklin, P.; Allgeier, H.; Auberson, Y.; Ofner, S.; Veenstra, S.J. (Novartis AG); Substd. aminoalkane phosphonic acids. EP 0934326; US 6117873; WO 9817672 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 48441 | 2,3-Diaminotoluene; o-Tolylenediamine | 2687-25-4 | C7H10N2 | 详情 | 详情 |
| (II) | 15713 | Oxalic acid | 144-62-7 | C2H2O4 | 详情 | 详情 |
| (III) | 48442 | 5-methyl-1,4-dihydro-2,3-quinoxalinedione | C9H8N2O2 | 详情 | 详情 | |
| (IV) | 48443 | 2,3-dichloro-5-methylquinoxaline | C9H6Cl2N2 | 详情 | 详情 | |
| (V) | 48444 | 2,3-dimethoxy-5-methylquinoxaline; 3-methoxy-5-methyl-2-quinoxalinyl methyl ether | C11H12N2O2 | 详情 | 详情 | |
| (VI) | 48445 | 5-(bromomethyl)-3-methoxy-2-quinoxalinyl methyl ether; 5-(bromomethyl)-2,3-dimethoxyquinoxaline | C11H11BrN2O2 | 详情 | 详情 | |
| (VII) | 48446 | 5-(bromomethyl)-3-methoxy-7-nitro-2-quinoxalinyl methyl ether; 5-(bromomethyl)-2,3-dimethoxy-7-nitroquinoxaline | C11H10BrN3O4 | 详情 | 详情 | |
| (VIII) | 48447 | Di-tert-butyl iminodicarboxylate; Iminodicarboxylic acid di-tert-butyl ester | 51779-32-9 | C10H19NO4 | 详情 | 详情 |
| (IX) | 48448 | 5-[[bis(tert-butoxycarbonyl)amino]methyl]-2,3-dimethoxy-7-nitroquinoxaline | C21H28N4O8 | 详情 | 详情 | |
| (X) | 48449 | (2,3-dimethoxy-7-nitro-5-quinoxalinyl)methanamine; (2,3-dimethoxy-7-nitro-5-quinoxalinyl)methylamine | C11H12N4O4 | 详情 | 详情 | |
| (XI) | 32359 | dimethyl phosphonate | 868-85-9 | C2H7O3P | 详情 | 详情 |
| (XII) | 48450 | dimethyl [[(2,3-dimethoxy-7-nitro-5-quinoxalinyl)methyl]amino]methylphosphonate | C14H19N4O7P | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：(II)Treatment of ethyl 3-(3-pyridyl)-2-oxopropionate (I) with dimethyl phosphite (II) provides derivative (III), which is finally converted into the desired compound by hydrolysis with HCl.
| 【1】 Bayless, A.V.; Dansereau, S.M.; Ebetino, F.H. (The Procter & Gamble Co.); Phosphonocarboxylate cpds. for treating abnormal calcium and phosphate metabolism. EP 0788362; EP 0849272; US 5391743; US 5824661; WO 9324131 . |