Mifobate, SR-202, -Drug Synthesis Database

【结构式】

【药物名称】Mifobate, SR-202

【化学名称】Dimethyl alpha-(dimethoxyphosphinyl) p-chlorobenzyl phosphate
　　　　　　(4-Chlorophenyl)(dimethoxyphophinyl)methyl phosphoric acid dimethyl ester
　　　　　　Dimethyl (p-chloro-alpha-hydroxybenzyl)phosphonate,dimethyl phosphate

【CA登记号】76541-72-5

【分子式】C₁₁H₁₇ClO₇P₂

【分子量】358.65454

【开发单位】Ilex Oncology (Originator)

【药理作用】Lipoprotein Disorders, Treatment of , METABOLIC DRUGS

合成路线1

The reaction of chlorobenzoyl chloride (I) with trimethyl phosphite gives dimethyl p-chlorobenzoylphosphonate (II). Addition of dimethyl phosphite to (II) in the presence of 80% molar amount of an organic base (e.g., di-n-butylamine) in diethyl ether or toluene at 0 C produces the final compound.

参考文献中间体

【1】 Bentzen, C.L.; Nguyen, M.L.; Niesor, E.; US 4309364 .
【2】 Nguyen, M.L.; Bentzen, C.L.; SR-202. Drugs Fut 1982, 7, 4, 271.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(A)	12642	Trimethyl phosphite	121-45-9	C₃H₉O₃P	详情	详情
(B)	32359	dimethyl phosphonate	868-85-9	C₂H₇O₃P	详情	详情
(I)	10295	p-Chlorobenzoyl chloride; 4-Chlorobenzoyl chloride	122-01-0	C₇H₄Cl₂O	详情	详情
(II)	36391	dimethyl 4-chlorobenzoylphosphonate		C₉H₁₀ClO₄P	详情	详情

Extended Information