【结 构 式】 |
【分子编号】36391 【品名】dimethyl 4-chlorobenzoylphosphonate 【CA登记号】 |
【 分 子 式 】C9H10ClO4P 【 分 子 量 】248.602462 【元素组成】C 43.48% H 4.05% Cl 14.26% O 25.74% P 12.46% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(II)The reaction of chlorobenzoyl chloride (I) with trimethyl phosphite gives dimethyl p-chlorobenzoylphosphonate (II). Addition of dimethyl phosphite to (II) in the presence of 80% molar amount of an organic base (e.g., di-n-butylamine) in diethyl ether or toluene at 0 C produces the final compound.
【1】 Bentzen, C.L.; Nguyen, M.L.; Niesor, E.; US 4309364 . |
【2】 Nguyen, M.L.; Bentzen, C.L.; SR-202. Drugs Fut 1982, 7, 4, 271. |
Extended Information