【结 构 式】 |
【药物名称】NE-10790 【化学名称】2-Hydroxy-2-phosphono-3-(3-pyridyl)propionic acid 【CA登记号】152831-36-2 【 分 子 式 】C8H10NO6P 【 分 子 量 】247.1458 |
【开发单位】Procter & Gamble (Originator) 【药理作用】Bone Diseases, Treatment of, Bone Resorption Inhibitors, METABOLIC DRUGS, Treatment of Osteoporosis, Bisphosphonates, Geranylgeranyl Transferase Inhibitors |
合成路线1
Treatment of ethyl 3-(3-pyridyl)-2-oxopropionate (I) with dimethyl phosphite (II) provides derivative (III), which is finally converted into the desired compound by hydrolysis with HCl.
【1】 Bayless, A.V.; Dansereau, S.M.; Ebetino, F.H. (The Procter & Gamble Co.); Phosphonocarboxylate cpds. for treating abnormal calcium and phosphate metabolism. EP 0788362; EP 0849272; US 5391743; US 5824661; WO 9324131 . |
Extended Information