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【结 构 式】 
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【分子编号】26922 【品名】methyl (1S,4aS,10aR)-6-methoxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-1-phenanthrenecarboxylate 【CA登记号】 |
【 分 子 式 】C19H26O3 【 分 子 量 】302.41364 【元素组成】C 75.46% H 8.67% O 15.87% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(II)The methylation of podocarpic acid (I) (J Org Chem 1974, 39: 1968) gives methyl O-methylpodocarpate (II), which is oxidized with CrO3 in acetic acid.
| 【1】 Hornback, W.J.; Munroe, J.E. (Eli Lilly and Company); Anti-viral cpds.. EP 0806408; JP 2000510468; WO 9741822 . |
| 【2】 Hornback, W.J.; Mauldin, S.C.; Munroe, J.E. (Eli Lilly and Company); Anti-viral cpds.. EP 0806411; JP 2000510464; WO 9742154 . |
| 【3】 Colacino, J.M.; Hornback, W.J.; Mauldin, S.C.; Munroe, J.E.; Tang, J.C.-C. (Eli Lilly and Company); Anti-viral method. WO 9741849 . |
合成路线2
该中间体在本合成路线中的序号：(I)The oxidation of methyl O-methylpodocarpate (I) with chromium trioxide produced ketone (II). This was then condensed with 1-amino-4-methylpiperazine (III) to yield the title hydrazone.
| 【1】 Sachs, R.K.; Hornback, W.J.; Tang, J.; Munroe, J.E.; In vitro and in vivo activity of a series of influenza A inhibitors derived from podocarpic acid. 39th Intersci Conf Antimicrob Agents Chemother (Sept 26 1999, San Francisco) 1999, Abst F950. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 26922 | methyl (1S,4aS,10aR)-6-methoxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-1-phenanthrenecarboxylate | C19H26O3 | 详情 | 详情 | |
| (II) | 40654 | methyl (1S,4aS)-6-methoxy-1,4a-dimethyl-9-oxo-1,2,3,4,4a,9,10,10a-octahydro-1-phenanthrenecarboxylate | C19H24O4 | 详情 | 详情 | |
| (III) | 40655 | 4-Methyl-1-piperazinamine; 1-Amino-4-methylpiperazine; 4-Methyl-1-piperazinylamine | 6928-85-4 | C5H13N3 | 详情 | 详情 |
Extended Information