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【结 构 式】 
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【药物名称】LY-314177 【化学名称】1(S),4a(S)-Dimethyl-6-methoxy-9-(4-methylpiperazin-1-ylimino)-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid methyl ester 【CA登记号】199291-57-1 (beta-isomer) 【 分 子 式 】C24H35N3O3 【 分 子 量 】413.56485 |
【开发单位】Lilly (Originator) 【药理作用】ANTIINFECTIVE THERAPY, Anti-Influenza A Virus Drugs, Anti-Influenza Virus Drugs, Antiviral Drugs |
合成路线1
The oxidation of methyl O-methylpodocarpate (I) with chromium trioxide produced ketone (II). This was then condensed with 1-amino-4-methylpiperazine (III) to yield the title hydrazone.
| 【1】 Sachs, R.K.; Hornback, W.J.; Tang, J.; Munroe, J.E.; In vitro and in vivo activity of a series of influenza A inhibitors derived from podocarpic acid. 39th Intersci Conf Antimicrob Agents Chemother (Sept 26 1999, San Francisco) 1999, Abst F950. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 26922 | methyl (1S,4aS,10aR)-6-methoxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-1-phenanthrenecarboxylate | C19H26O3 | 详情 | 详情 | |
| (II) | 40654 | methyl (1S,4aS)-6-methoxy-1,4a-dimethyl-9-oxo-1,2,3,4,4a,9,10,10a-octahydro-1-phenanthrenecarboxylate | C19H24O4 | 详情 | 详情 | |
| (III) | 40655 | 4-Methyl-1-piperazinamine; 1-Amino-4-methylpiperazine; 4-Methyl-1-piperazinylamine | 6928-85-4 | C5H13N3 | 详情 | 详情 |
Extended Information