methyl (1S,4aS)-6-methoxy-1,4a-dimethyl-9-oxo-1,2,3,4,4a,9,10,10a-octahydro-1-phenanthrenecarboxylate -Drug Synthesis Database

【结构式】

【分子编号】40654

【品名】methyl (1S,4aS)-6-methoxy-1,4a-dimethyl-9-oxo-1,2,3,4,4a,9,10,10a-octahydro-1-phenanthrenecarboxylate

【CA登记号】

【分子式】C₁₉H₂₄O₄

【分子量】316.39716

【元素组成】C 72.13% H 7.65% O 20.23%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The oxidation of methyl O-methylpodocarpate (I) with chromium trioxide produced ketone (II). This was then condensed with 1-amino-4-methylpiperazine (III) to yield the title hydrazone.

参考文献中间体

合成目标

【1】 Sachs, R.K.; Hornback, W.J.; Tang, J.; Munroe, J.E.; In vitro and in vivo activity of a series of influenza A inhibitors derived from podocarpic acid. 39th Intersci Conf Antimicrob Agents Chemother (Sept 26 1999, San Francisco) 1999, Abst F950.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	26922	methyl (1S,4aS,10aR)-6-methoxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-1-phenanthrenecarboxylate		C₁₉H₂₆O₃	详情	详情
(II)	40654	methyl (1S,4aS)-6-methoxy-1,4a-dimethyl-9-oxo-1,2,3,4,4a,9,10,10a-octahydro-1-phenanthrenecarboxylate		C₁₉H₂₄O₄	详情	详情
(III)	40655	4-Methyl-1-piperazinamine; 1-Amino-4-methylpiperazine; 4-Methyl-1-piperazinylamine	6928-85-4	C₅H₁₃N₃	详情	详情

Extended Information