(1S,4aS,10aR)-6-hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-1-phenanthrenecarboxylic acid -Drug Synthesis Database

【结构式】

【分子编号】26921

【品名】(1S,4aS,10aR)-6-hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-1-phenanthrenecarboxylic acid

【CA登记号】5947-49-9

【分子式】C₁₇H₂₂O₃

【分子量】274.35988

【元素组成】C 74.42% H 8.08% O 17.49%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

The methylation of podocarpic acid (I) (J Org Chem 1974, 39: 1968) gives methyl O-methylpodocarpate (II), which is oxidized with CrO3 in acetic acid.

【1】 Hornback, W.J.; Munroe, J.E. (Eli Lilly and Company); Anti-viral cpds.. EP 0806408; JP 2000510468; WO 9741822 .
【2】 Hornback, W.J.; Mauldin, S.C.; Munroe, J.E. (Eli Lilly and Company); Anti-viral cpds.. EP 0806411; JP 2000510464; WO 9742154 .
【3】 Colacino, J.M.; Hornback, W.J.; Mauldin, S.C.; Munroe, J.E.; Tang, J.C.-C. (Eli Lilly and Company); Anti-viral method. WO 9741849 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	26921	(1S,4aS,10aR)-6-hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-1-phenanthrenecarboxylic acid	5947-49-9	C₁₇H₂₂O₃	详情	详情
(II)	26922	methyl (1S,4aS,10aR)-6-methoxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-1-phenanthrenecarboxylate		C₁₉H₂₆O₃	详情	详情

Extended Information