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【结 构 式】

【分子编号】22548

【品名】4-[[amino(imino)methyl]amino]benzoyl chloride

【CA登记号】

【 分 子 式 】C8H8ClN3O

【 分 子 量 】197.62384

【元素组成】C 48.62% H 4.08% Cl 17.94% N 21.26% O 8.1%

与该中间体有关的原料药合成路线共 3 条

合成路线1

该中间体在本合成路线中的序号:(III)

This compound can be prepared by condensation of 4-guanidinobenzoic acid (I) with 6-amidino-2-naphthol (II) in pyridine either by means of DCC or the acid chloride of (I), (III), at room temperature.

1 Fujii, S.; Okutome, T.; Nakayama, T.; Yaegashi, T.; Kurumi, M. (Torii Pharmaceutical Co., Ltd.); Amidine compound. JP 82179146; JP 8253454; US 4454338 .
2 Aoyama, T.; Nafamstat Mesylate. Drugs Fut 1984, 9, 10, 747.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 29755 4-[[amino(imino)methyl]amino]benzoic acid C8H9N3O2 详情 详情
(II) 12515 6-Hydroxy-2-naphthalenecarboximidamide C11H10N2O 详情 详情
(III) 22548 4-[[amino(imino)methyl]amino]benzoyl chloride C8H8ClN3O 详情 详情

合成路线2

该中间体在本合成路线中的序号:(V)

The reaction of p-hydrophenylacetic acid (I) with N,N-dimethylbromoacetamide (II) by means of triethylamine in reftuxing acetonitrile gives N,N-dimethylcarbamoylmethyl-p-hydroxyphenylacetate (III), which is then condensed with p-guanidinobenzoyl chloride (IV) [obtained from the corresponding acid p-guanidinobenzoic acid (V) and thionyl chloride] in pyridine.

1 Fujii, S.; Uegai, Y.; Watanabe, T.; Kayama, N. (Ono Pharmaceutical Co., Ltd.); Guanidinobenzoic acid derivatives. DE 2548886; FR 2289181; GB 1472700; JP 76054530; US 4021472 .
2 Fujii, S.; et al. (Ono Pharmaceutical Co., Ltd.); Guanidinobenzoic acid derivatives and antiplasmin agents and remedies for pancreas diseases containing the said guanidinobensolc acid derivatives. JP 52089640 .
3 Castaner, J.; Serradell, M.N.; Hashimoto, K.; Camostat Mesylate. Drugs Fut 1985, 10, 11, 897.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 18430 2-(4-Hydroxyphenyl)acetic acid; 4-Hydroxyphenylacetic acid 156-38-7 C8H8O3 详情 详情
(II) 29753 2-bromo-N,N-dimethylacetamide C4H8BrNO 详情 详情
(III) 29754 2-(dimethylamino)-2-oxoethyl 2-(4-hydroxyphenyl)acetate C12H15NO4 详情 详情
(IV) 29755 4-[[amino(imino)methyl]amino]benzoic acid C8H9N3O2 详情 详情
(V) 22548 4-[[amino(imino)methyl]amino]benzoyl chloride C8H8ClN3O 详情 详情

合成路线3

该中间体在本合成路线中的序号:(VI)

The alkylation of succinimide (I) with 1,2-dibromoethane (II) by means of K2CO3 in refluxing butanone gives N-(2-bromoethyl)succinimide (III), which is condensed with 4-hydroxythiophenol (IV) by means of K2CO3 in refluxing ethanol to afford 4-hydroxyphenyl 2-succinimidoethyl sulfide (V). Finally, this compound is esterified with 4-guanidinobenzoyl chloride in pyridine, and treated with methanesulfonic acid in methanol.

1 Hishinuma, I.; Kawashima, H.; Kawata, T.; Miyamoto, K.; Miyazawa, S.; Nagakawa, J.; Nagaoka, J.; Nagaoka, N.; Shimomura, N.; Souda, S.; Ueda, N.; Wakabayashi, T.; Yamanaka, T. (Eisai Co., Ltd.); Guanidinobenzoic ester deriv., a process for preparing same and pharmaceutical compsns. containing same. EP 0229370; JP 1987155253; JP 1994298730; US 4801603; US 5075335 .
2 Prous, J.; Castaner, J.; E-3123. Drugs Fut 1988, 13, 7, 613.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 22543 2,5-pyrrolidinedione 123-56-8 C4H5NO2 详情 详情
(II) 10252 1,2-Dibromoethane; Ethylene dibromide 106-93-4 C2H4Br2 详情 详情
(III) 22545 1-(2-bromoethyl)-2,5-pyrrolidinedione C6H8BrNO2 详情 详情
(IV) 22546 4-sulfanylphenol 637-89-8 C6H6OS 详情 详情
(V) 22547 1-[2-[(4-hydroxyphenyl)sulfanyl]ethyl]-2,5-pyrrolidinedione C12H13NO3S 详情 详情
(VI) 22548 4-[[amino(imino)methyl]amino]benzoyl chloride C8H8ClN3O 详情 详情
Extended Information