6-Hydroxy-2-naphthalenecarboximidamide -Drug Synthesis Database

【结构式】

【分子编号】12515

【品名】6-Hydroxy-2-naphthalenecarboximidamide

【CA登记号】

【分子式】C₁₁H₁₀N₂O

【分子量】186.21328

【元素组成】C 70.95% H 5.41% N 15.04% O 8.59%

与该中间体有关的原料药合成路线共 2 条

合成路线1 合成路线2

合成路线1

该中间体在本合成路线中的序号：(II)

This compound can be prepared by condensation of 4-guanidinobenzoic acid (I) with 6-amidino-2-naphthol (II) in pyridine either by means of DCC or the acid chloride of (I), (III), at room temperature.

参考文献中间体

合成目标

【1】 Fujii, S.; Okutome, T.; Nakayama, T.; Yaegashi, T.; Kurumi, M. (Torii Pharmaceutical Co., Ltd.); Amidine compound. JP 82179146; JP 8253454; US 4454338 .
【2】 Aoyama, T.; Nafamstat Mesylate. Drugs Fut 1984, 9, 10, 747.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	29755	4-[[amino(imino)methyl]amino]benzoic acid	C₈H₉N₃O₂	详情	详情
(II)	12515	6-Hydroxy-2-naphthalenecarboximidamide	C₁₁H₁₀N₂O	详情	详情
(III)	22548	4-[[amino(imino)methyl]amino]benzoyl chloride	C₈H₈ClN₃O	详情	详情

合成路线2

该中间体在本合成路线中的序号：(II)

Esterification of 4-(4,5-dihydro-1H-imidazol-2-ylamino)benzoic acid methanesulfonate (I) with 6-amidino-2-naphthol methanesulfonate (II) by means of dimethylaminopyridine (DMAP) and dicyclohexylcarbodiimide (DCC) in dry pyridine.

参考文献中间体

合成目标

【1】 Graul, A.; Leeson, P.; Castaner, J.; Sepimostat Mesylate. Drugs Fut 1997, 22, 5, 502.
【2】 Fujii, S.; Okutome, T.; Nakayama, T.; Nunomura, S.; Sudo, K.; Watanabe, S.; Kurumi, M.; Aoyama, T. (Torii Pharmaceutical Co., Ltd.); Novel amidine cpds. AU 8545492; EP 0190356; ES 8607218; US 4777182; US 4820730; WO 8600893 .
【3】 Nakayama, T.; Ikeda, M.; Taira, S.; Ashizawa, H.; Oda, M.; Fujii, S.; Arakawa, K.; Synthesis and structure-activity study of protease inhibitors. V. Chemical modification of 6-amidino-2-naphthyl 4-guanidinobenzoate. Chem Pharm Bull 1993, 41, 1, 117-25.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	12514	4-(4,5-Dihydro-1H-imidazol-2-ylamino)benzoic acid		C₁₀H₁₁N₃O₂	详情	详情
(II)	12515	6-Hydroxy-2-naphthalenecarboximidamide		C₁₁H₁₀N₂O	详情	详情

Extended Information