Nafamostat mesilate, Nafamostat mesylate, FUT-175, Futhan, -Drug Synthesis Database

【结构式】

【药物名称】Nafamostat mesilate, Nafamostat mesylate, FUT-175, Futhan

【化学名称】6-Amidino-2-naphthyl p-guanidinobenzoate dimethanesulfonate
　　　　　　6-Amidino-2-naphthyl 4-guanidinobenzoate dimethanesulfonate

【CA登记号】82956-11-4, 80251-32-7 (diHCl), 81525-10-2 (free base)

【分子式】C₂₁H₂₅N₅O₈S₂

【分子量】539.5901

【开发单位】Torii (Originator)

【药理作用】GASTROINTESTINAL DRUGS, Pancreatic Disorders, Treatment of, Protease Inhibitors

合成路线1

This compound can be prepared by condensation of 4-guanidinobenzoic acid (I) with 6-amidino-2-naphthol (II) in pyridine either by means of DCC or the acid chloride of (I), (III), at room temperature.

参考文献中间体

【1】 Fujii, S.; Okutome, T.; Nakayama, T.; Yaegashi, T.; Kurumi, M. (Torii Pharmaceutical Co., Ltd.); Amidine compound. JP 82179146; JP 8253454; US 4454338 .
【2】 Aoyama, T.; Nafamstat Mesylate. Drugs Fut 1984, 9, 10, 747.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	29755	4-[[amino(imino)methyl]amino]benzoic acid	C₈H₉N₃O₂	详情	详情
(II)	12515	6-Hydroxy-2-naphthalenecarboximidamide	C₁₁H₁₀N₂O	详情	详情
(III)	22548	4-[[amino(imino)methyl]amino]benzoyl chloride	C₈H₈ClN₃O	详情	详情

Extended Information