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【结 构 式】 
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【分子编号】22531 【品名】4-Bromoaniline; 4-Bromophenylamine 【CA登记号】106-40-1 |
【 分 子 式 】C6H6BrN 【 分 子 量 】172.02438 【元素组成】C 41.89% H 3.52% Br 46.45% N 8.14% |
合成路线1
该中间体在本合成路线中的序号：(VIII)The reaction of 4-chloro-1-(4-fluorophenyl)-1-butanone (I) with ethylene glycol and p-toluenesulfonic acid in refluxing benzene gives the corresponding ethyleneketal (II), which is condensed with 4-hydroxypiperidine (III) by means of K2CO3 in hot DMF yielding 1-(4-fluorophenyl)-4-(4-hydroxypiperidin-1-yl)-1-butanone ethyleneketal (IV). The Oppenauer oxidation of (IV) with 9-fluorenone and potassium tert-butoxide in hot benzene affords the piperidinone (V), which is condensed with 4-bromo-N-(trimethylsilyl)aniline (VI) by means of BuLi in hot hexane to give 4-[4-(4-aminophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)-1-butanone (VII). Finally, this compound is treated with CuBr2 and NO in THF.
| 【1】 Vincent, S.H.; et al.; Synthesis of [82Br]bromperidol and preliminary tissue distribution studies in the rat. J Med Chem 1980, 23, 1, 75. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 11295 | Polyethylene glycol;1,2-Ethanediol;Monoethylene glycol; Ethylene glycol | 107-21-1 | C2H6O2 | 详情 | 详情 | |
| (I) | 35864 | 4-chloro-1-(4-fluorophenyl)-1-butanone | 3874-54-2 | C10H10ClFO | 详情 | 详情 |
| (II) | 28203 | 2-(3-chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane | 3308-94-9 | C12H14ClFO2 | 详情 | 详情 |
| (III) | 12076 | 4-Piperidinol; 4-Hydroxypiperidine | 5382-16-1 | C5H11NO | 详情 | 详情 |
| (IV) | 35865 | 1-[3-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]propyl]-4-piperidinol | C17H24FNO3 | 详情 | 详情 | |
| (V) | 35866 | 1-[3-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]propyl]-4-piperidinone | C17H22FNO3 | 详情 | 详情 | |
| (VI) | 35867 | N-(4-bromophenyl)(trimethyl)silanamine; N-(4-bromophenyl)-N-(trimethylsilyl)amine | C9H14BrNSi | 详情 | 详情 | |
| (VII) | 35868 | 4-[4-(4-aminophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone | C21H25FN2O2 | 详情 | 详情 | |
| (VIII) | 22531 | 4-Bromoaniline; 4-Bromophenylamine | 106-40-1 | C6H6BrN | 详情 | 详情 |
| (IX) | 35869 | C6H5Br2MgN | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(VIII)The reaction of 4-chloro-1-(4-fluorophenyl)-1-butanone (I) with ethylene glycol and p-toluenesulfonic acid in refluxing benzene gives the corresponding ethylene-ketal (II), which is condensed with 4-hydroxypiperidine (III) by means of K2CO3 in hot DMF yielding 1-(4-fluorophenyl)-4-(4-hydroxypiperidin-1-yl)-1-butanone ethyle-neketal (IV). The Oppenauer oxidation of (IV) with 9-fluorenone and potassium tert-butoxide in hot benzene affords the piperidinone (V), which is condensed with 4-bromo-N-(trimethylsilyl)aniline (VI) by means of BuLi in hot hexane to give 4-[4-(4-aminophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)-1-butanone (VII). Finally, this compound is treated with Cu82Br2 and NO in THF.
| 【1】 Vincent, S.H.; et al.; Synthesis of [82Br]bromperidol and preliminary tissue distribution studies in the rat. J Med Chem 1980, 23, 1, 75. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 11295 | Polyethylene glycol;1,2-Ethanediol;Monoethylene glycol; Ethylene glycol | 107-21-1 | C2H6O2 | 详情 | 详情 | |
| (I) | 35864 | 4-chloro-1-(4-fluorophenyl)-1-butanone | 3874-54-2 | C10H10ClFO | 详情 | 详情 |
| (II) | 28203 | 2-(3-chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane | 3308-94-9 | C12H14ClFO2 | 详情 | 详情 |
| (III) | 12076 | 4-Piperidinol; 4-Hydroxypiperidine | 5382-16-1 | C5H11NO | 详情 | 详情 |
| (IV) | 35865 | 1-[3-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]propyl]-4-piperidinol | C17H24FNO3 | 详情 | 详情 | |
| (V) | 35866 | 1-[3-[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]propyl]-4-piperidinone | C17H22FNO3 | 详情 | 详情 | |
| (VI) | 35867 | N-(4-bromophenyl)(trimethyl)silanamine; N-(4-bromophenyl)-N-(trimethylsilyl)amine | C9H14BrNSi | 详情 | 详情 | |
| (VII) | 35868 | 4-[4-(4-aminophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone | C21H25FN2O2 | 详情 | 详情 | |
| (VIII) | 22531 | 4-Bromoaniline; 4-Bromophenylamine | 106-40-1 | C6H6BrN | 详情 | 详情 |
| (IX) | 35869 | C6H5Br2MgN | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(XVI)Tritiated saquinavir: The cyclization of 4-bromoaniline (XVI) with crotonic aldehyde (II) by means of ZnCl2/HCl gives 6-bromo-4-methylquinoline (XVII), which is brominated as before giving tetrabromo derivative (XVIII). The hydrolysis of (XVIII) with sulfuric cid affords 6-bromoquinoline-2-carboxylic acid (XIX), which is condensed with Ro-32-0445 (VI) by means of HOBT and DCC as indicated giving the bromo derivative of saquinavir (XX). Finally, this compound is tritiated with T2 over Pd/C in ethanol.
| 【1】 Wiltshire, H.R.; et al.; The synthesis of labelled forms of saquinavir. J Label Compd Radiopharm 1998, 41, 12, 1103. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (II) | 22517 | (E)-2-butenal | 4170-30-3 | C4H6O | 详情 | 详情 |
| (VI) | 22521 | (2S)-N(1)-[(1S,2R)-3-[(3S,4aS,8aS)-3-[(tert-butylamino)carbonyl]octahydro-2(1H)-isoquinolinyl]-1-benzyl-2-hydroxypropyl]-2-aminobutanediamide | C28H45N5O4 | 详情 | 详情 | |
| (XVI) | 22531 | 4-Bromoaniline; 4-Bromophenylamine | 106-40-1 | C6H6BrN | 详情 | 详情 |
| (XVII) | 22532 | 6-bromo-2-methylquinoline | 877-42-9 | C10H8BrN | 详情 | 详情 |
| (XVIII) | 22533 | 6-bromo-2-(tribromomethyl)quinoline | C10H5Br4N | 详情 | 详情 | |
| (XIX) | 22534 | 6-bromo-2-quinolinecarboxylic acid | C10H6BrNO2 | 详情 | 详情 | |
| (XX) | 22535 | (2S)-N(1)-[(1S,2R)-3-[(3S,4aS,8aS)-3-[(tert-butylamino)carbonyl]octahydro-2(1H)-isoquinolinyl]-1-benzyl-2-hydroxypropyl]-2-[[(6-bromo-2-quinolinyl)carbonyl]amino]butanediamide | C38H49BrN6O5 | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：(VI)Reaction of 4-bromoaniline (VI) with methanesulfonyl chloride afforded the bis sulfonamido derivative (VII). Palladium-catalyzed coupling of (VII) with 6-methoxybenzo[b]thiophene-2-boronic acid (VIII) then provided the 2-aryl benzothiophene (IX). Subsequent Friedel-Crafts acylation of (IX) with acid chloride (V) in the presence of AlCl3 gave rise to ketone (X). The methyl ether group of (X) was finally cleaved by treatment with ethanethiol and AlCl3.
| 【1】 Dantzig, A.H.; Grese, T.A.; Normal, B.H.; Palkowitz, A.D.; Sluka, J.P.; Starling, J.J. II; Winter, M.A. (Eli Lilly and Company); Methods for treating resistant tumors. EP 0773217; JP 2000500138; WO 9717069 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (V) | 36995 | 4-[2-(1-piperidinyl)ethoxy]benzoyl chloride | C14H18ClNO2 | 详情 | 详情 | |
| (VI) | 22531 | 4-Bromoaniline; 4-Bromophenylamine | 106-40-1 | C6H6BrN | 详情 | 详情 |
| (VII) | 36996 | N-(4-bromophenyl)-N-(methylsulfonyl)methanesulfonamide | C8H10BrNO4S2 | 详情 | 详情 | |
| (VIII) | 25015 | 6-methoxy-1-benzothiophen-2-ylboronic acid | C9H9BO3S | 详情 | 详情 | |
| (IX) | 36997 | N-[4-(6-methoxy-1-benzothiophen-2-yl)phenyl]-N-(methylsulfonyl)methanesulfonamide | C17H17NO5S3 | 详情 | 详情 | |
| (X) | 36998 | N-[4-(6-methoxy-3-[4-[2-(1-piperidinyl)ethoxy]benzoyl]-1-benzothiophen-2-yl)phenyl]-N-(methylsulfonyl)methanesulfonamide | C31H34N2O7S3 | 详情 | 详情 |
合成路线5
该中间体在本合成路线中的序号：(XVI)3-Cyanobenzaldehyde oxime (I) was treated with N-chlorosuccinimide to afford hydroxyiminoyl chloride (II). Subsequent cycloaddition of the intermediate nitrile oxide, generated in situ from (II) and Et3N, with methyl methoxyacrylate (III) produced isoxazole (IV). Then, basic hydrolysis of the ester group, followed by treatment with SOCl2 provided acid chloride (V). Aminobiphenyl (VIII) was obtained by Suzuki coupling of 4-bromoaniline (VI) with boronic acid (VII) using a palladium catalyst. Condensation of (VIII) with acid chloride (V) in the presence of Et3N then gave amide (IX). Alternatively, amide (IX) was obtained by AlMe3-catalyzed condensation of ester (IV) with amine (VIII). Treatment of nitrile (IX) with HCl in MeOH-CHCl3 generated the corresponding iminoester (X) with concomitant cleavage of the N-tert-butyl group. Finally, reaction of this iminoester with methanolic ammonium carbonate afforded the target amidine.
| 【1】 Wexler, R.R.; Bostrom, L.L.; Pinto, D.J.; Wrong, P.C.; Pruitt, J.R.; Knabb, R.M.; Estrella, M.J.; Quan, M.L.; Isoxazolines and isoxazoles as factor Xa inhibitor. 216th ACS Natl Meet (Aug. 23-27, Boston) 1998, Abst MEDI 077. |
| 【2】 Quan, M.L.; Pinto, D.J.P.; Fevig, J.M.; Pruitt, J.R. (DuPont Pharmaceuticals Co.); Oxygen or sulfur containing heteroaromatics as fac. WO 9828282 . |
| 【3】 Pinto, D.J.P.; Pruitt, J.R.; Fevig, J.M.; Quan, M.L. (DuPont Pharmaceuticals Co.); Phenyl-isoxazoles as factor Xa inhibitors. US 6187797 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 23357 | 3-[(hydroxyimino)methyl]benzonitrile | C8H6N2O | 详情 | 详情 | |
| (II) | 23358 | 3-cyano-N-hydroxybenzenecarboximidoyl chloride | C8H5ClN2O | 详情 | 详情 | |
| (IV) | 23360 | methyl 3-(3-cyanophenyl)-4-isoxazolecarboxylate | C12H8N2O3 | 详情 | 详情 | |
| (V) | 23361 | 3-(3-cyanophenyl)-4-isoxazolecarbonyl chloride | C11H5ClN2O2 | 详情 | 详情 | |
| (VII) | 23363 | 4'-amino-N-(tert-butyl)[1,1'-biphenyl]-2-sulfonamide | C16H20N2O2S | 详情 | 详情 | |
| (VIII) | 23364 | 3-(3-cyanophenyl)-4-isoxazolecarbonyl chloride | C11H5ClN2O2 | 详情 | 详情 | |
| (IX) | 23365 | N-[2'-[(tert-butylamino)sulfonyl][1,1'-biphenyl]-4-yl]-3-(3-cyanophenyl)-4-isoxazolecarboxamide | C27H24N4O4S | 详情 | 详情 | |
| (X) | 23366 | methyl 3-[4-([[2'-(aminosulfonyl)[1,1'-biphenyl]-4-yl]amino]carbonyl)-3-isoxazolyl]benzenecarboximidoate | C24H20N4O5S | 详情 | 详情 | |
| (XII) | 22700 | methyl (E)-3-methoxy-2-propenoate | 34846-90-7 | C5H8O3 | 详情 | 详情 |
| (XVI) | 22531 | 4-Bromoaniline; 4-Bromophenylamine | 106-40-1 | C6H6BrN | 详情 | 详情 |
合成路线6
该中间体在本合成路线中的序号：(I)The Skraup reaction of 4-bromoaniline (I) with acetone and iodine afforded dihydroquinoline (II), which was protected as the tert-butyl carbamate (III) with Boc2O in the presence of n-BuLi. Lithium-halogen exchange in (III), followed by treatment with trimethyl borate provided boronic acid (IV). Subsequent Suzuki coupling of (IV) with 3-bromobenzonitrile (V) using tetrakis(triphenylphosphine)-palladium produced the 6-arylquinoline (VI). The Boc group of (VI) was finally removed with trifluoroacetic acid to furnish the title compound.
| 【1】 Pooley, C.L.F.; Edwards, J.P.; Goldman, M.E.; Wang, M.-W.; Marschke, K.B.; Crombie, D.L.; Jones, T.K.; Discovery and preliminary SAR studies of a novel, nonsteroidal progesterone receptor antagonist phamacophore. J Med Chem 1998, 41, 18, 3461. |
| 【2】 Jones, T.K.; Goldman, M.E.; Pooley, C.L.F.; Winn, D.T.; Edwards, J.E.; West, S.J.; Tegley, C.M.; Zhi, L.; Hamann, L.G.; Farmer, L.J.; Davis, R.J. (Ligand Pharmaceuticals, Inc.); Steroid receptor modulator cpds. and methods. EP 0800519; JP 1998510840; US 5688808; US 5688810; US 5693646; US 5693647; US 5696127; US 5696130; US 5696133; WO 9619458 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 22531 | 4-Bromoaniline; 4-Bromophenylamine | 106-40-1 | C6H6BrN | 详情 | 详情 |
| (II) | 26570 | 6-bromo-2,2,4-trimethyl-1,2-dihydroquinoline | C12H14BrN | 详情 | 详情 | |
| (III) | 26571 | tert-butyl 6-bromo-2,2,4-trimethyl-1(2H)-quinolinecarboxylate | C17H22BrNO2 | 详情 | 详情 | |
| (IV) | 26572 | 1-(tert-butoxycarbonyl)-2,2,4-trimethyl-1,2-dihydro-6-quinolinylboronic acid | C17H24BNO4 | 详情 | 详情 | |
| (V) | 26573 | 3-bromobenzonitrile | 6952-59-6 | C7H4BrN | 详情 | 详情 |
| (VI) | 26574 | tert-butyl 6-(3-cyanophenyl)-2,2,4-trimethyl-1(2H)-quinolinecarboxylate | C24H26N2O2 | 详情 | 详情 |
合成路线7
该中间体在本合成路线中的序号：(I)The Skraup reaction of 4-bromoaniline (I) with acetone and iodine afforded dihydroquinoline (II), which was protected as the tert-butyl carbamate (III) with Boc2O in the presence of n-BuLi. Subsequent lithium-halogen exchange in (III), followed by treatment with trimethyl borate provided boronic acid (IV). Nitrile (VI) was obtained by treatment of 1,3-dibromo-5-fluorobenzene (V) with cuprous cyanide in DMF. Then, Suzuki coupling of boronic acid (IV) with bromobenzonitrile (VI) using tetrakis(triphenylphosphine)-palladium produced the 6-arylquinoline (VII). The Boc group of (VII) was finally removed with trifluoroacetic acid to furnish the title compound.
| 【1】 Pooley, C.L.F.; Edwards, J.P.; Goldman, M.E.; Wang, M.-W.; Marschke, K.B.; Crombie, D.L.; Jones, T.K.; Discovery and preliminary SAR studies of a novel, nonsteroidal progesterone receptor antagonist phamacophore. J Med Chem 1998, 41, 18, 3461. |
| 【2】 Jones, T.K.; Goldman, M.E.; Pooley, C.L.F.; Winn, D.T.; Edwards, J.E.; West, S.J.; Tegley, C.M.; Zhi, L.; Hamann, L.G.; Farmer, L.J.; Davis, R.J. (Ligand Pharmaceuticals, Inc.); Steroid receptor modulator cpds. and methods. EP 0800519; JP 1998510840; US 5688808; US 5688810; US 5693646; US 5693647; US 5696127; US 5696130; US 5696133; WO 9619458 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 22531 | 4-Bromoaniline; 4-Bromophenylamine | 106-40-1 | C6H6BrN | 详情 | 详情 |
| (II) | 26570 | 6-bromo-2,2,4-trimethyl-1,2-dihydroquinoline | C12H14BrN | 详情 | 详情 | |
| (III) | 26571 | tert-butyl 6-bromo-2,2,4-trimethyl-1(2H)-quinolinecarboxylate | C17H22BrNO2 | 详情 | 详情 | |
| (IV) | 26572 | 1-(tert-butoxycarbonyl)-2,2,4-trimethyl-1,2-dihydro-6-quinolinylboronic acid | C17H24BNO4 | 详情 | 详情 | |
| (V) | 26575 | 1,3-dibromo-5-fluorobenzene | 1435-51-4 | C6H3Br2F | 详情 | 详情 |
| (VI) | 26576 | 3-bromo-5-fluorobenzonitrile | C7H3BrFN | 详情 | 详情 | |
| (VII) | 26577 | tert-butyl 6-(3-cyano-5-fluorophenyl)-2,2,4-trimethyl-1(2H)-quinolinecarboxylate | C24H25FN2O2 | 详情 | 详情 |
合成路线8
该中间体在本合成路线中的序号：(V)Treatment of 6,7-dichloro-5,8-quinoxalinedione (I) with sodium azide in AcOH afforded azide (II), which was reduced to amine (III) using NaBH4. Acetylation of (III) with Ac2O and a catalytic amount of H2SO4 yielded amide (IV). Subsequent reaction of (IV) with 4-bromoaniline (V) produced the corresponding (4-bromophenyl)aminoquinoxaline (VI). Finally, conversion of (VI) into the target imidazole was performed by treatment with NaOH in refluxing EtOH.
| 【1】 Yoo, H.-W.; Suh, M.-E.; Park, S.W.; Synthesis and cytotoxicity of 2-methyl-4,9-dihydro-1-substituted-1H-imidazo[4,5-g]quinoxaline-4,9-diones and 2,3-disubstituted-5,10-pyrazino[2,3-g]quinoxalinediones. J Med Chem 1998, 41, 24, 4716. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 28550 | 6,7-dichloro-5,8-quinoxalinedione | C8H2Cl2N2O2 | 详情 | 详情 | |
| (II) | 28551 | 6-azido-7-chloro-5,8-quinoxalinedione | C8H2ClN5O2 | 详情 | 详情 | |
| (III) | 28552 | 6-amino-7-chloro-5,8-quinoxalinedione | C8H4ClN3O2 | 详情 | 详情 | |
| (IV) | 28553 | N-(7-chloro-5,8-dioxo-5,8-dihydro-6-quinoxalinyl)acetamide | C10H6ClN3O3 | 详情 | 详情 | |
| (V) | 22531 | 4-Bromoaniline; 4-Bromophenylamine | 106-40-1 | C6H6BrN | 详情 | 详情 |
| (VI) | 28554 | N-[7-(4-bromoanilino)-5,8-dioxo-5,8-dihydro-6-quinoxalinyl]acetamide | C16H11BrN4O3 | 详情 | 详情 |
合成路线9
该中间体在本合成路线中的序号：(I)The reaction of 4-bromoaniline (I) with potassium thiocyanate and bromine in acetic acid gives the benzothiazole (III) through the intermediate (II). The hydrolysis of (III) with NaOH affords 4-bromo-2-sulfanylaniline (IV), which is cyclized with 4-hydroxy-6-methyl-2-oxo-3-cyclohexene-1-carboxylic acid tert-butyl ester (V) in refluxing toluene.
| 【1】 Laws, M.L.; Roberts, R.R.; Nicholson, J.M.; Butcher, R.; Stables, J.P.; Goodwin, A.M.; Smith, C.A.; Scott, K.R.; Synthesis, characterization, and anticonvulsant activity of enaminones. Part 5: Investigations on 3-carboalkoxy-2-methyl-2,3-dihydro-1H-phenothiazin-4[10H]-one derivatives. Bioorg Med Chem 1998, 6, 12, 2289. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 22531 | 4-Bromoaniline; 4-Bromophenylamine | 106-40-1 | C6H6BrN | 详情 | 详情 |
| (II) | 25569 | 2-amino-5-bromobenzenesulfenyl cyanide | C7H5BrN2S | 详情 | 详情 | |
| (III) | 25570 | 6-bromo-1,3-benzothiazol-2-amine; 6-bromo-1,3-benzothiazol-2-ylamine | 15864-32-1 | C7H5BrN2S | 详情 | 详情 |
| (IV) | 25571 | 2-amino-5-bromobenzenethiol; 2-amino-5-bromophenylhydrosulfide | C6H6BrNS | 详情 | 详情 | |
| (V) | 25572 | tert-butyl 4-hydroxy-6-methyl-2-oxo-3-cyclohexene-1-carboxylate | C12H18O4 | 详情 | 详情 |
合成路线10
该中间体在本合成路线中的序号：(IX)The reaction of N-tert-butylbenzenesulfonamide (I) with triisopropyl borate by means of BuLi in THF gives the boronic acid (II), which is condensed with 4-bromonitrobenzene (III) by means of palladium tetrakis(triphenylphosphine) to yield the N-tert-butyl-4'-nitrobiphenyl-2-sulfonamide (IV). The reduction of (IV) with H2 over Pd/C in methanol affords the biphenylamine (V), which is acylated with 3-(3-cyanophenyl)-5-(methoxycarbonylmethyl)-4,5-dihydroisoxazole-5-carboxylic acid (VI), by means of SOCl2 in acetonitrile affording the corresponding amide (VII). The reaction of (VII) with trifluoroacetic acid eliminates the tert-butyl protecting group providing intermediate (VIII). Finally, the cyano group of (VIII) is converted into amidino by reaction with HCl in chloroform/methanol and reaction of the intermediate imidate with ammonium acetate. Alternatively, biphenylamine (V) can also be obtained as follows: The reaction of 4-bromoaniline (IX) with tert-butoxycarbonyl anhydride in THF gives the corresponding carbamate (X), which is condensed with the boronic acid (II) by means of palladium tetrakis triphenylphosphine and deprotected with trifluoroacetic acid to afford the target intermediate (V).
| 【1】 Quan, M.L.; Wityak, J.; Galemmo, R.A. Jr.; Stouten, P.F.W.; Pruitt, J.R. (DuPont Pharmaceuticals Co.); Isoxazoline, isothiazoline and pyrazoline factor Xa inhibitors. EP 0874629; US 5939418; WO 9723212 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 26626 | N-(tert-butyl)benzenesulfonamide | C10H15NO2S | 详情 | 详情 | |
| (II) | 26627 | 2-[(tert-butylamino)sulfonyl]phenylboronic acid | C10H16BNO4S | 详情 | 详情 | |
| (III) | 26628 | 1-bromo-4-nitrobenzene | 99-99-0 | C6H4BrNO2 | 详情 | 详情 |
| (IV) | 26629 | N-(tert-butyl)-4'-nitro[1,1'-biphenyl]-2-sulfonamide | C16H18N2O4S | 详情 | 详情 | |
| (V) | 23363 | 4'-amino-N-(tert-butyl)[1,1'-biphenyl]-2-sulfonamide | C16H20N2O2S | 详情 | 详情 | |
| (VI) | 26630 | 3-(3-cyanophenyl)-5-(2-methoxy-2-oxoethyl)-4,5-dihydro-5-isoxazolecarboxylic acid | C14H12N2O5 | 详情 | 详情 | |
| (VII) | 26631 | methyl 2-[5-[([2'-[(tert-butylamino)sulfonyl][1,1'-biphenyl]-4-yl]amino)carbonyl]-3-(3-cyanophenyl)-4,5-dihydro-5-isoxazolyl]acetate | C30H30N4O6S | 详情 | 详情 | |
| (VIII) | 26632 | methyl 2-[5-([[2'-(aminosulfonyl)[1,1'-biphenyl]-4-yl]amino]carbonyl)-3-(3-cyanophenyl)-4,5-dihydro-5-isoxazolyl]acetate | C26H22N4O6S | 详情 | 详情 | |
| (IX) | 22531 | 4-Bromoaniline; 4-Bromophenylamine | 106-40-1 | C6H6BrN | 详情 | 详情 |
| (X) | 26633 | tert-butyl 4-bromophenylcarbamate | C11H14BrNO2 | 详情 | 详情 |
合成路线11
该中间体在本合成路线中的序号：(IV)The reductive alkylation of 4-(2-methoxyphenoxy)aniline (I) with pyridine-3-carboxaldehyde (II) in the presence of NaBH4 leads to the N-pyridylmethyl aniline adduct (III) (1). Alternatively, 4-bromoaniline (IV) is reductively alkylated with pyridine-3-carboxaldehyde (II) to produce (V). Subsequent copper-catalyzed bromide displacement of (V) with guaiacol (VI) affords intermediate (III) (2). Finally, acylation of amine (III) with 2,2,2-trifluoroethylsulfonyl chloride (VII) gives rise to the target sulfonamide (1,2).
| 【1】 Johnson, M.P.; Baez, M.; Jagdmann, G.E.Jr.; Britton, T.C.; Large, T.H.; Callagaro, D.O.; Tizzano, J.P.; Monn, J.A.; Schoepp, D.D.; Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: Synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2-trifluoroethylsulfonyl)pyrid-3-ylmethylamine. J Med Chem 2003, 46, 15, 3189. |
| 【2】 Monn, J.A.; Hornback, W.J.; Schoepp, D.D.; Dressman, B.A.; Britton, T.C.; Tizzano, J.P.; Johnson, K.W.; Henry, S.S.; Coleman, D.S.; Jagdmann, G.E.J.; Johnson, M.P.; Large, T.H.; Barda, D.A.; Fichtner, M.W. (Eli Lilly and Company); Potentiators of glutamate receptors. WO 0156990 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 65013 | 4-{[2-(methyloxy)phenyl]oxy}aniline; 4-{[2-(methyloxy)phenyl]oxy}phenylamine | C13H13NO2 | 详情 | 详情 | |
| (II) | 12849 | Nicotinaldehyde; 3-Pyridinecarboxaldehyde | 500-22-1 | C6H5NO | 详情 | 详情 |
| (III) | 65014 | N-(4-{[2-(methyloxy)phenyl]oxy}phenyl)-N-(3-pyridinylmethyl)amine; 4-{[2-(methyloxy)phenyl]oxy}-N-(3-pyridinylmethyl)aniline | C19H18N2O2 | 详情 | 详情 | |
| (IV) | 22531 | 4-Bromoaniline; 4-Bromophenylamine | 106-40-1 | C6H6BrN | 详情 | 详情 |
| (V) | 65015 | 4-bromo-N-(3-pyridinylmethyl)aniline; N-(4-bromophenyl)-N-(3-pyridinylmethyl)amine | C12H11BrN2 | 详情 | 详情 | |
| (VI) | 13052 | 4-((5R,5aR,8aR,9S)-9-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methylhexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-6-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxyphenyl dibenzyl phosphate | C43H45O16P | 详情 | 详情 | |
| (VII) | 65016 | 2,2,2-trifluoro-1-ethanesulfonyl chloride | C2H2ClF3O2S | 详情 | 详情 |
合成路线12
该中间体在本合成路线中的序号：(XIII)Addition of triisopropyl borate to the ortho-lithiated derivative of N-tert-butyl benzenesulfonamide (XI), followed by acid aqueous work-up, gives rise to the boronic acid (XII). Subsequent Suzuki coupling between (XII) and 4-bromoaniline (XIII) affords the biphenyl sulfonamide (XIV). Then, trimethylaluminum-catalyzed condensation of the pyrazole ester (X) with the biphenyl amine (XIV) generates amide (XV). The N-tert-butyl protecting group of (XV) is finally cleaved with trifluoroacetic acid to furnish the title compound.
| 【1】 Jia, Z.J.; et al.; Design, synthesis and biological activity of novel non-amidine factor Xa inhibitors: Part 1: Structure-activity relationships of the substituted 1-(2-naphthyl)-1H-pyrazole-5-carboxylamides. Bioorg Med Chem Lett 2002, 12, 12, 1651. |
| 【2】 Wang, L.; Zhu, B.-Y.; Li, W.; Zhang, P.; Huang, W.; Song, Y.; Goldman, E.; Zuckett, J.; Scarborough, R. (Millennium Pharmaceuticals, Inc.); Benzamides and related inhibitors of factor Xa. EP 1216228; EP 1216231; WO 0119788; WO 0119798 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (X) | 57034 | ethyl 1-(3-fluoro-2-naphthyl)-3-methyl-1H-pyrazole-5-carboxylate | C17H15FN2O2 | 详情 | 详情 | |
| (XI) | 26626 | N-(tert-butyl)benzenesulfonamide | C10H15NO2S | 详情 | 详情 | |
| (XII) | 26627 | 2-[(tert-butylamino)sulfonyl]phenylboronic acid | C10H16BNO4S | 详情 | 详情 | |
| (XIII) | 22531 | 4-Bromoaniline; 4-Bromophenylamine | 106-40-1 | C6H6BrN | 详情 | 详情 |
| (XIV) | 23363 | 4'-amino-N-(tert-butyl)[1,1'-biphenyl]-2-sulfonamide | C16H20N2O2S | 详情 | 详情 | |
| (XV) | 57035 | N-{2'-[(tert-butylamino)sulfonyl][1,1'-biphenyl]-4-yl}-1-(3-fluoro-2-naphthyl)-3-methyl-1H-pyrazole-5-carboxamide | C31H29FN4O3S | 详情 | 详情 |
合成路线13
该中间体在本合成路线中的序号：(I)Condensation of 4-bromoaniline (I) with 3-phenylpropionyl chloride (II) by means of triethylamine in dichloromethane gives the propionamide (III), which is cyclized with dimethylformamide by means of POCl3 in hot DMF to yield 3-benzyl-6-bromo-2-chloroquinoline (IV). Reaction of compound (IV) with NaOMe in refluxing methanol affords the 2-methoxyquinoline derivative (V), which is condensed with 3-(dimethylamino)-1-(1-naphthyl)propanone (VI) by means of BuLi in THF to provide a mixture of two diastereomeric racemates (R*,R*/R*,S*) (VII) that are separated by column chromatography. Finally, the desired (R*,S*)-racemic mixture is submitted to chiral chromatography (1). Scheme 1.
In an improved process, 3-benzyl-6-bromo-2-methoxyquinoline (V) is condensed with 3-(dimethylamino)-1-(1-naphthyl)propanone (VI) by means of LDA in THF and then treated with AcOH to afford the tertiary alcohol (VII). Finally, alcohol (VII) is submitted to optical resolution by crystallization with chiral 4-hydroxydinaphtho[2,1-d:1’,2’-f][1,3,2]dioxaphosphepin 4-oxide (2). Scheme 1.
| 【1】 Van Gestel, J.F.E., Venet, M.G., Vernier, D.F.J., Decrane, L.F.B., Poignet, H.J.J. (Janssen Pharmaceutica NV). Quinoline derivatives and their use as mycobacterial inhibitors. CA 2493225, EP 1527050, JP 2006504658, WO 2004011436. |
| 【2】 Porstmann, F.R., Horns, S., Bader, T. (Janssen Pharmaceutica NV). Process for preparing (alphaS,betaR)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol. CA 2606675, EP 1888604, US 2008200683, WO 2006125769. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 22531 | 4-Bromoaniline; 4-Bromophenylamine | 106-40-1 | C6H6BrN | 详情 | 详情 |
| (II) | 16240 | 3-phenylpropanoyl chloride; Hydrocinnamoylchloride | 645-45-4 | C9H9ClO | 详情 | 详情 |
| (III) | 65794 | N-(4-Bromophenyl)-3-Phenylpropanamide | 316146-27-7 | C15H14BrNO | 详情 | 详情 |
| (IV) | 65795 | 6-Bromo-2-chloro-3-(phenylmethyl)quinoline | 654655-68-2 | C16H11BrClN | 详情 | 详情 |
| (V) | 65796 | 3-Benzyl-6-bromo-2-methoxyquinoline | 654655-69-3 | C17H14BrNO | 详情 | 详情 |
| (VI) | 65797 | 3-(Dimethylamino)-1-(naphthalen-1-yl)propan-1-one; (2-alpha-Naphthoylethyl)dimethylamine; 2-(Dimethylamino)ethyl 1-naphthyl ketone | 10320-49-7 | C15H17NO | 详情 | 详情 |
| (VII) | 65798 | 6-Bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol | 654655-80-8 | C32H31BrN2O2 | 详情 | 详情 |
合成路线14
该中间体在本合成路线中的序号：(Ia)Cyclization of 4-bromoaniline (Ia) with methyl vinyl ketone (II) by means of H2SO4 in refluxing dioxane affords 6-bromo-4-methylquinoline (IIIa) (1). Similarly, cyclization of 4-aminobenzonitrile (Ib) with methyl vinyl ketone (II) by means of HCl and chloranil in EtOH gives 4-methyl-6-quinolinecarbonitrile (IIIb) (2). Condensation of 4-methylquinolines (IIIa) or (IIIb) with methyl 6-methylpyridine-2-carboxylate (IV) by means of KHMDS in THF at –70 °C or t-BuONa in THF (2) produces the 2-(4-quinolinyl)-1-(pyridyl)ethanone derivatives (Va) (1) or (Vb) (2), respectively. Subsequent condensation of ketone (Va) with 1-amino-2-pyrrolidinone hydrochloride (VIa) in pyridine yields acyl hydrazone (VIIa), which is cyclized by means of Cs2CO3 in DMF at 100 °C, leading to the pyrrolopyrazole derivative (IXa) (1). Alternatively, condensation of ketone (Vb) with 1-amino-2-pyrrolidinone p-toluenesulfonate (VIb) [prepared by the hydrolysis of hydrazone (VIII) with p-TsOH·H2O in toluene] in the presence of 2,6-lutidine in refluxing DMF/toluene provides the acyl hydrazone (VIIb), which cyclizes to the pyrrolopyrazole derivative (IXb) by treatment with K2CO3 (2). Finally, methoxycarbonylation of bromoquinoline (IXa) under CO atmosphere in the presence of Pd(dppf)2Cl2 and NaOAc in MeOH at 80 °C gives the methyl ester (X), which is submitted to ammonolysis with NH3 in MeOH at 90 °C. Alternatively, nitrile (IXb) is hydrolyzed by means of H2O2 and K2CO3 in DMSO/H2O .
| 【1】 Beight, D.W., Yingling, J.M., Sawyer, J.S. (Eli Lilly and Company). Quinolinyl-pyrrolopyrazoles. CA 2501322, EP 1565471, JP 2006514012, US 2006040983, US 7265225, WO 2004048382. |
| 【2】 Mundla, S.R. (Eli Lilly and Company). A pyridine quinolin substituted pyrrolo[1,2-b]pyrazole monohydrate as TGF-beta inhibitor. EP 19103 |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (Ia) | 22531 | 4-Bromoaniline; 4-Bromophenylamine | 106-40-1 | C6H6BrN | 详情 | 详情 |
| (Ib) | 15361 | 4-Aminobenzonitrile | 873-74-5 | C7H6N2 | 详情 | 详情 |
| (IIIa) | 67742 | 6-bromo-4-methylquinoline | 41037-28-9 | C10H8BrN | 详情 | 详情 |
| (IIIb) | 67743 | 4-methyl-6-quinolinecarbonitrile | C11H8N2 | 详情 | 详情 | |
| (Va) | 67744 | 2-(6-bromoquinolin-4-yl)-1-(6-methylpyridin-2-yl)ethanone | C17H13BrN2O | 详情 | 详情 | |
| (Vb) | 67745 | 4-(2-(6-methylpyridin-2-yl)-2-oxoethyl)quinoline-6-carbonitrile | C18H13N3O | 详情 | 详情 | |
| (VIa) | 67746 | 1-amino-2-pyrrolidinone hydrochloride | 20386-22-5 | C4H8N2O.HCl | 详情 | 详情 |
| (VIb) | 67747 | 1-aminopyrrolidin-2-one 4-methylbenzenesulfonate | C7H83S.C4H8N2O | 详情 | 详情 | |
| (VIIa) | 67749 | (E)-1-((2-(6-bromoquinolin-4-yl)-1-(6-methylpyridin-2-yl)ethylidene)amino)pyrrolidin-2-one | C21H19BrN4O | 详情 | 详情 | |
| (VIIb) | 67748 | (E)-4-(2-(6-methylpyridin-2-yl)-2-((2-oxopyrrolidin-1-yl)imino)ethyl)quinoline-6-carbonitrile | C22H19N5O | 详情 | 详情 | |
| (IXa) | 67751 | 6-bromo-4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline | C21H17BrN4 | 详情 | 详情 | |
| (IXb) | 67752 | 4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carbonitrile | C22H17N5 | 详情 | 详情 | |
| (II) | 30324 | 3-buten-2-one; methyl vinyl ketone | 78-94-4 | C4H6O | 详情 | 详情 |
| (IV) | 62758 | methyl 6-methyl-2-pyridinecarboxylate | 13602-11-4 | C8H9NO2 | 详情 | 详情 |
| (VIII) | 67750 | 1-((diphenylmethylene)amino)pyrrolidin-2-one | C17H16N2O | 详情 | 详情 | |
| (X) | 67753 | methyl 4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxylate | C23H20N4O2 | 详情 | 详情 |