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【结 构 式】 
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【分子编号】36998 【品名】N-[4-(6-methoxy-3-[4-[2-(1-piperidinyl)ethoxy]benzoyl]-1-benzothiophen-2-yl)phenyl]-N-(methylsulfonyl)methanesulfonamide 【CA登记号】 |
【 分 子 式 】C31H34N2O7S3 【 分 子 量 】642.81824 【元素组成】C 57.92% H 5.33% N 4.36% O 17.42% S 14.97% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(X)Reaction of 4-bromoaniline (VI) with methanesulfonyl chloride afforded the bis sulfonamido derivative (VII). Palladium-catalyzed coupling of (VII) with 6-methoxybenzo[b]thiophene-2-boronic acid (VIII) then provided the 2-aryl benzothiophene (IX). Subsequent Friedel-Crafts acylation of (IX) with acid chloride (V) in the presence of AlCl3 gave rise to ketone (X). The methyl ether group of (X) was finally cleaved by treatment with ethanethiol and AlCl3.
| 【1】 Dantzig, A.H.; Grese, T.A.; Normal, B.H.; Palkowitz, A.D.; Sluka, J.P.; Starling, J.J. II; Winter, M.A. (Eli Lilly and Company); Methods for treating resistant tumors. EP 0773217; JP 2000500138; WO 9717069 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (V) | 36995 | 4-[2-(1-piperidinyl)ethoxy]benzoyl chloride | C14H18ClNO2 | 详情 | 详情 | |
| (VI) | 22531 | 4-Bromoaniline; 4-Bromophenylamine | 106-40-1 | C6H6BrN | 详情 | 详情 |
| (VII) | 36996 | N-(4-bromophenyl)-N-(methylsulfonyl)methanesulfonamide | C8H10BrNO4S2 | 详情 | 详情 | |
| (VIII) | 25015 | 6-methoxy-1-benzothiophen-2-ylboronic acid | C9H9BO3S | 详情 | 详情 | |
| (IX) | 36997 | N-[4-(6-methoxy-1-benzothiophen-2-yl)phenyl]-N-(methylsulfonyl)methanesulfonamide | C17H17NO5S3 | 详情 | 详情 | |
| (X) | 36998 | N-[4-(6-methoxy-3-[4-[2-(1-piperidinyl)ethoxy]benzoyl]-1-benzothiophen-2-yl)phenyl]-N-(methylsulfonyl)methanesulfonamide | C31H34N2O7S3 | 详情 | 详情 |
Extended Information