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【结 构 式】 
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【分子编号】18625 【品名】tert-butyl 4-hydroxy-1-piperidinecarboxylate 【CA登记号】 |
【 分 子 式 】C10H19NO3 【 分 子 量 】201.2658 【元素组成】C 59.68% H 9.52% N 6.96% O 23.85% |
合成路线1
该中间体在本合成路线中的序号：(I)Swern oxidation of 4-hydroxypiperidine-1-carboxylic acid tert-butyl ester (I) with oxalyl chloride in DMSO/dichloromethane gives the corresponding piperidone (II), which is submitted to a Grignard reaction with [U-14C]phenylmagnesium bromide (III) in THF to yield 4-hydroxy-4-phenylpiperidine-1-carboxylic acid tert-butyl ester (IV). The reaction of (IV) with BF3/Et2O in dichloromethane affords labeled 4-phenyl-1,2,3,6-tetrahydropyridine (V), which is condensed with 3-phenyl-3-cyclohexene-1(R)-carboxylic acid (VI) by means of HOBT, DCC and TEA in ethyl acetate to provide the labeled 1-(3-phenyl-3-cyclohexen-1(R)-yl)-1-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)methanone (VII). Finally, this compound is reduced with LiAlH4 and AlCl3 in THF to obtain the target tetrahydropyridine derivative.
| 【1】 Ekhato, I.V.; Huang, C.C.; Synthesis of (R)-(+)-1,2,3,6-tetrahydro-4-[U-14C]phenyl-1[(3-phenyl-3-cyclohexenyl-1-yl)methyl]pyridine, a potential antipsychotic agent. J Label Compd Radiopharm 1995, 36, 1, 57. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 18625 | tert-butyl 4-hydroxy-1-piperidinecarboxylate | C10H19NO3 | 详情 | 详情 | |
| (II) | 18620 | tert-butyl 4-oxo-1-piperidinecarboxylate;BOC-Piperidone;N-(tert-Butoxycarbonyl)-4-piperidone; N-Boc-4-piperidone | 79099-07-3 | C10H17NO3 | 详情 | 详情 |
| (II) | 45167 | C6H5BrMg | 详情 | 详情 | ||
| (III) | 17616 | bromo(phenyl)magnesium; Phenyl Magnesium Bromide | 100-58-3 | C6H5BrMg | 详情 | 详情 |
| (IV) | 57878 | tert-butyl 4-hydroxy-4-phenyl-1-piperidinecarboxylate | C16H23NO3 | 详情 | 详情 | |
| (IV) | 64702 | tert-butyl 4-hydroxy-4-phenyl-1-piperidinecarboxylate | C16H23NO3 | 详情 | 详情 | |
| (V) | 13002 | 4-Phenyl-1,2,3,6-tetrahydropyridine; 1,2,3,6-Tetrahydro-4-phenyl-pyridine | 10338-69-9 | C11H13N | 详情 | 详情 |
| (V) | 64703 | 4-Phenyl-1,2,3,6-tetrahydro-pyridine | 10338-69-9 | C11H13N | 详情 | 详情 |
| (VI) | 57879 | (1R)-3-phenyl-3-cyclohexene-1-carboxylic acid | C13H14O2 | 详情 | 详情 | |
| (VII) | 54955 | [(1R)-3-phenyl-3-cyclohexen-1-yl][4-phenyl-3,6-dihydro-1(2H)-pyridinyl]methanone | C24H25NO | 详情 | 详情 | |
| (VII) | 64704 | [(1R)-3-phenyl-3-cyclohexen-1-yl][4-phenyl-3,6-dihydro-1(2H)-pyridinyl]methanone | C24H25NO | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(VII)1) 2-Aminobenzyl alcohol (I) was condensed with N-tert-butoxycarbonyl-4-piperidone (II) in toluene with azeotropical removal of water, and the resulting imine (III) was reduced with sodium cyanoborohydride to yield the secondary amine (IV). Further treatment of (IV) with triphosgene in the presence of N,N-diisopropyl ethylamine (DIEA) produced the benzoxazinone (V), which was then deprotected with HCl in EtOAc to give piperidine (VI).
| 【1】 Development of orally active oxytocin antagonists: Studies on 1-(1-[4-[1-(2-methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2-methoxybenzoyl]piperidin-4-yl)-1, 4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and related pyridines. J Med Chem 1998, 41, 12, 2146. |
| 【2】 Bock, M.G.; Evans, B.E.; Hobbs, D.W.; Williams, P.D.; Anderson, P.S.; Freidinger, R.M.; Pettibone, D.J. (Merck & Co., Inc.); Benzoxazinone and benzopyrimidinone piperidinyl tocolytic oxytocin receptor antagonists. EP 0714299; JP 1997500134; US 5665719; WO 9502405 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 18619 | (2-aminophenyl)methanol; 2-Amino-benzenemethanol；2-Hydroxymethyl aniline;2-aminobenzyl alcohol;o-Aminobenzyl 2-aminobenzylalcohol;alcohol; 2-aminobenzenemethanol; 2-aminobenzyl alcohol | 5344-90-1 | C7H9NO | 详情 | 详情 |
| (II) | 18620 | tert-butyl 4-oxo-1-piperidinecarboxylate;BOC-Piperidone;N-(tert-Butoxycarbonyl)-4-piperidone; N-Boc-4-piperidone | 79099-07-3 | C10H17NO3 | 详情 | 详情 |
| (III) | 19417 | tert-butyl 4-[[2-(hydroxymethyl)phenyl]imino]-1-piperidinecarboxylate | C17H24N2O3 | 详情 | 详情 | |
| (IV) | 18621 | tert-butyl 4-[2-(hydroxymethyl)anilino]-1-piperidinecarboxylate | C17H26N2O3 | 详情 | 详情 | |
| (V) | 18622 | tert-butyl 4-[2-oxo-2H-3,1-benzoxazin-1(4H)-yl]-1-piperidinecarboxylate | C18H24N2O4 | 详情 | 详情 | |
| (VI) | 19420 | 1-(4-piperidinyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one | C13H16N2O2 | 详情 | 详情 | |
| (VII) | 18625 | tert-butyl 4-hydroxy-1-piperidinecarboxylate | C10H19NO3 | 详情 | 详情 | |
| (VIII) | 16623 | methyl 2,4-dihydroxybenzoate | 2150-47-2 | C8H8O4 | 详情 | 详情 |
| (IX) | 19423 | tert-butyl 4-[3-hydroxy-4-(methoxycarbonyl)phenoxy]-1-piperidinecarboxylate | C18H25NO6 | 详情 | 详情 | |
| (X) | 18627 | tert-butyl 4-[3-methoxy-4-(methoxycarbonyl)phenoxy]-1-piperidinecarboxylate | C19H27NO6 | 详情 | 详情 | |
| (XI) | 18628 | 4-[[1-(tert-butoxycarbonyl)-4-piperidinyl]oxy]-2-methoxybenzoic acid | C18H25NO6 | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(VII)Condensation of 2-(hydroxymethyl)aniline (I) with N-Boc-4-piperidone (II), followed by reduction with NaBH3CN provided anilinopiperidine (III). Cyclization of aminoalcohol (III) with triphosgene gave benzoxazinone (IV), which was deprotected by acidic treatment to yield piperidinylbenzoxazinone (V). Methyl 2,4-dihydroxybenzoate (VI) was selectively alkylated on the 4-position by coupling with N-Boc-4-piperidinol (VII) under Mitsunobu conditions to give ether (VIII). Then, the remaining 2-OH group was methylated with MeI and NaH to give (IX), which was saponified to provide the benzoic acid derivative (X). Coupling of amine (V) and acid (X) using EDC and HOBt produced amide (XI). Then, removal of the tert-butoxycarbonyl group by acid treatment, followed by acetylation of the resulting piperidine (XII) with Ac2O, furnished the target compound.
| 【1】 Williams, P.D.; et al.; 1-[1-[4-[(N-Acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]piperidin-4-yl]-4H-3,1-benzoxazin-2(1H)-one (L-371, 257): A new, orally bioavailable, non-peptide oxytocin antagonist. J Med Chem 1995, 38, 23, 4634. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 18619 | (2-aminophenyl)methanol; 2-Amino-benzenemethanol；2-Hydroxymethyl aniline;2-aminobenzyl alcohol;o-Aminobenzyl 2-aminobenzylalcohol;alcohol; 2-aminobenzenemethanol; 2-aminobenzyl alcohol | 5344-90-1 | C7H9NO | 详情 | 详情 |
| (II) | 18620 | tert-butyl 4-oxo-1-piperidinecarboxylate;BOC-Piperidone;N-(tert-Butoxycarbonyl)-4-piperidone; N-Boc-4-piperidone | 79099-07-3 | C10H17NO3 | 详情 | 详情 |
| (III) | 18621 | tert-butyl 4-[2-(hydroxymethyl)anilino]-1-piperidinecarboxylate | C17H26N2O3 | 详情 | 详情 | |
| (IV) | 18622 | tert-butyl 4-[2-oxo-2H-3,1-benzoxazin-1(4H)-yl]-1-piperidinecarboxylate | C18H24N2O4 | 详情 | 详情 | |
| (V) | 18623 | 1-(4-piperidinyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one hydrochloride | C13H17ClN2O2 | 详情 | 详情 | |
| (VI) | 16623 | methyl 2,4-dihydroxybenzoate | 2150-47-2 | C8H8O4 | 详情 | 详情 |
| (VII) | 18625 | tert-butyl 4-hydroxy-1-piperidinecarboxylate | C10H19NO3 | 详情 | 详情 | |
| (VIII) | 19423 | tert-butyl 4-[3-hydroxy-4-(methoxycarbonyl)phenoxy]-1-piperidinecarboxylate | C18H25NO6 | 详情 | 详情 | |
| (IX) | 18627 | tert-butyl 4-[3-methoxy-4-(methoxycarbonyl)phenoxy]-1-piperidinecarboxylate | C19H27NO6 | 详情 | 详情 | |
| (X) | 18628 | 4-[[1-(tert-butoxycarbonyl)-4-piperidinyl]oxy]-2-methoxybenzoic acid | C18H25NO6 | 详情 | 详情 | |
| (XI) | 18629 | tert-butyl 4-[3-methoxy-4-([4-[2-oxo-2H-3,1-benzoxazin-1(4H)-yl]-1-piperidinyl]carbonyl)phenoxy]-1-piperidinecarboxylate | C31H39N3O7 | 详情 | 详情 | |
| (XII) | 18630 | 1-[1-[2-methoxy-4-(4-piperidinyloxy)benzoyl]-4-piperidinyl]-1,4-dihydro-2H-3,1-benzoxazin-2-one hydrochloride | C26H32ClN3O5 | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：(I)N-Boc-4-Hydroxypiperidine (I) was converted to the mesylate (II) with methanesulfonyl chloride and pyridine. Then, alkylation of 3-methyl-4-phenylpyrazole (III) with (II) in the presence of NaH yielded a mixture of regioisomeric pyrazoles (IV) and (V), which were separated using flash chromatography. The required isomer (IV) was subsequently treated with HCl in Et2O to remove the Boc protecting group. The resulting piperidine (VI) was finally alkylated with 3-(bromomethyl)benzonitrile (VII) to afford the title compound.
| 【1】 Bonner, K.; Jones, E.A.; Moore, K.W.; et al.; 4-N-Linked-heterocyclic piperidine derivatives with high affinity and selectivity for human dopamine D4 receptors. Bioorg Med Chem Lett 1999, 9, 9, 1285. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 18625 | tert-butyl 4-hydroxy-1-piperidinecarboxylate | C10H19NO3 | 详情 | 详情 | |
| (II) | 25308 | tert-butyl 4-[(methylsulfonyl)oxy]-1-piperidinecarboxylate | C11H21NO5S | 详情 | 详情 | |
| (III) | 25309 | 3-methyl-4-phenyl-1H-pyrazole | 3566-44-7 | C10H10N2 | 详情 | 详情 |
| (IV) | 25310 | tert-butyl 4-(5-methyl-4-phenyl-1H-pyrazol-1-yl)-1-piperidinecarboxylate | C20H27N3O2 | 详情 | 详情 | |
| (V) | 25311 | tert-butyl 4-(3-methyl-4-phenyl-1H-pyrazol-1-yl)-1-piperidinecarboxylate | C20H27N3O2 | 详情 | 详情 | |
| (VI) | 25312 | 4-(5-methyl-4-phenyl-1H-pyrazol-1-yl)piperidine | C15H19N3 | 详情 | 详情 | |
| (VII) | 13244 | alpha-Bromo-m-tolunitrile; 3-(Bromomethyl)benzonitrile | 28188-41-2 | C8H6BrN | 详情 | 详情 |
合成路线5
该中间体在本合成路线中的序号：(I)The intermediate aniline (IV) was synthesized by Mitsunobu coupling between N-Boc-4-piperidinol (I) and p-nitrophenol (II), followed by catalytic hydrogenation of the resultant nitrophenyl ether (III). 7-Formyl-2-naphthalenecarbonitrile (VI) was prepared by oxidation of the bromomethyl(naphthalene) (V) employing either trimethylamine N-oxide or dimethylsulfoxide in the presence of silver tetrafluoroborate. Reductive alkylation of aniline (IV) with aldehyde (VI) by means of sodium triacetoxyborohydride produced the secondary amine (VII), which was subsequently acylated with ethyl 2-(Chlorosulfonyl)acetate (VIII) to furnish sulfonamide (IX). The required amidine (X) was then obtained by Pinner reaction of nitrile (IX) with ethanolic HCl, followed by treatment with ammonium acetate. The deprotected piperidine moiety of (X) was further subjected to condensation with ethyl acetimidate to give the bis-amidine compound (XI). The ethyl ester group of (XI) was finally hydrolyzed under acidic conditions, yielding the target carboxylic acid.
| 【1】 Hirayama, F.; et al.; The discovery of YM-60828: A potent, selective and orally-bioavailable factor Xa inhibitor. Bioorg Med Chem 2002, 10, 5, 1509. |
| 【2】 Hirayama, F.; Koshio, H.; Matsumoto, Y.; Kawasaki, T.; Kaku, S.; Yanagisawa, I. (Yamanouchi Pharmaceutical Co., Ltd.); Novel amidinonaphthyl derivs. or salt thereof. EP 0798295; US 5869501; WO 9616940 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 18625 | tert-butyl 4-hydroxy-1-piperidinecarboxylate | C10H19NO3 | 详情 | 详情 | |
| (II) | 11236 | 4-Nitrophenol; p-Nitrophenol | 100-02-7 | C6H5NO3 | 详情 | 详情 |
| (III) | 55852 | tert-butyl 4-(4-nitrophenoxy)-1-piperidinecarboxylate | C16H22N2O5 | 详情 | 详情 | |
| (IV) | 55853 | tert-butyl 4-(4-aminophenoxy)-1-piperidinecarboxylate | C16H24N2O3 | 详情 | 详情 | |
| (V) | 24988 | 7-(bromomethyl)-2-naphthonitrile | C12H8BrN | 详情 | 详情 | |
| (VI) | 55854 | 7-formyl-2-naphthonitrile | C12H7NO | 详情 | 详情 | |
| (VII) | 55855 | tert-butyl 4-(4-{[(7-cyano-2-naphthyl)methyl]amino}phenoxy)-1-piperidinecarboxylate | C28H31N3O3 | 详情 | 详情 | |
| (VIII) | 55856 | ethyl 2-(chlorosulfonyl)acetate | C4H7ClO4S | 详情 | 详情 | |
| (IX) | 55857 | tert-butyl 4-(4-{[(7-cyano-2-naphthyl)methyl][(2-ethoxy-2-oxoethyl)sulfonyl]amino}phenoxy)-1-piperidinecarboxylate | C32H37N3O7S | 详情 | 详情 | |
| (X) | 55858 | ethyl 2-{[({7-[amino(imino)methyl]-2-naphthyl}methyl)-4-(4-piperidinyloxy)anilino]sulfonyl}acetate | C27H32N4O5S | 详情 | 详情 | |
| (XI) | 55859 | ethyl 2-({({7-[amino(imino)methyl]-2-naphthyl}methyl)-4-[(1-ethanimidoyl-4-piperidinyl)oxy]anilino}sulfonyl)acetate | C29H35N5O5S | 详情 | 详情 |
合成路线6
该中间体在本合成路线中的序号：(VII)The reaction of 7-hydroxy-1,2,3,4-tetrahydroisoquinoline (I) with di-tert-butyl dicarbonate and triethylamine in dichloromethane gives 7-hydroxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester (II), which is condensed with 2-(4-benzyloxyphenyl)-2-chloroacetic acid ethyl ester (III) (obtained by chlorination of 2-(4-benzyloxyphenyl)acetic acid ethyl ester (IV) with PCl5), by means of K2CO3 in refluxing acetonitrile yields the disubstituted acetate (V). The selective debenzylation of (V) with H2 over Pd/C in ethyl acetate affords the phenol (VI), which is alkylated with 4-hydroxypiperidine-1-carboxylic acid tert-butyl ester (VII) by means of diethyl azodicarboxylate (AZE) and triphenyl phosphine providing the protected intermediate (VIII). The deprotection of (VIII) with HCl in ethanol gives intermediate (IX) with two free NH groups, which is treated with pyrazole-1-carboxamidine (X) and diisopropylethylamine (DIEA) in DMF yielding the bis amidino derivative (XI), which is finally hydrolyzed with NaOH in ethanol/water.
| 【1】 Kucznierz, R.; Von der Saal, W.; Leinert, H.; Grams, F.; Stegmeier, K. (Roche Diagnostics GmbH); New cyclic guanidines, process for preparing the same and medicaments. DE 19530996; EP 0846115; JP 1999511445; WO 9708165 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 28634 | 1,2,3,4-tetrahydro-7-isoquinolinol | C9H11NO | 详情 | 详情 | |
| (II) | 28635 | tert-butyl 7-hydroxy-3,4-dihydro-2(1H)-isoquinolinecarboxylate | C14H19NO3 | 详情 | 详情 | |
| (III) | 28636 | ethyl 2-[4-(benzyloxy)phenyl]-2-chloroacetate | C17H17ClO3 | 详情 | 详情 | |
| (IV) | 28637 | Ethyl 2-[4-(benzyloxy)phenyl]acetate; p-(Benzyloxy)phenylacetate | C17H18O3 | 详情 | 详情 | |
| (V) | 28638 | tert-butyl 7-[1-[4-(benzyloxy)phenyl]-2-ethoxy-2-oxoethoxy]-3,4-dihydro-2(1H)-isoquinolinecarboxylate | C31H35NO6 | 详情 | 详情 | |
| (VI) | 28639 | tert-butyl 7-[2-ethoxy-1-(4-hydroxyphenyl)-2-oxoethoxy]-3,4-dihydro-2(1H)-isoquinolinecarboxylate | C24H29NO6 | 详情 | 详情 | |
| (VII) | 18625 | tert-butyl 4-hydroxy-1-piperidinecarboxylate | C10H19NO3 | 详情 | 详情 | |
| (VIII) | 28640 | tert-butyl 7-[1-(4-[[1-(tert-butoxycarbonyl)-4-piperidinyl]oxy]phenyl)-2-ethoxy-2-oxoethoxy]-3,4-dihydro-2(1H)-isoquinolinecarboxylate | C34H46N2O8 | 详情 | 详情 | |
| (IX) | 28641 | ethyl 2-[4-(4-piperidinyloxy)phenyl]-2-(1,2,3,4-tetrahydro-7-isoquinolinyloxy)acetate | C24H30N2O4 | 详情 | 详情 | |
| (X) | 15983 | 1H-pyrazole-1-carboximidamide | 4023-00-1 | C4H6N4 | 详情 | 详情 |
| (XI) | 28642 | ethyl 2-[4-([1-[amino(imino)methyl]-4-piperidinyl]oxy)phenyl]-2-([2-[amino(imino)methyl]-1,2,3,4-tetrahydro-7-isoquinolinyl]oxy)acetate | C26H34N6O4 | 详情 | 详情 |
合成路线7
该中间体在本合成路线中的序号：(VIII)Regioselective Mitsunobu condensation of 2',4'-dihydroxyacetophenone (VII) with N-Boc-4-piperidinol (VIII) afforded ether (IX). The 2'-hydroxyl group of (IX) was then alkylated with 2,2,2-trifluoroethyl trifluoromethanesulfonate in the presence of Cs2CO3 to give (X). Oxidative rearrangement of the acetophenone (X) employing thallium trinitrate and trimethyl orthoformate generated the phenylacetic ester (XI), which was hydrolyzed to acid (XII) with NaOH in aqueous MeOH. Subsequent EDC-mediated coupling of (XII) with piperidine intermediate (VI) yielded amide (XIII). The N-Boc group of (XIII) was cleaved using HCl in EtOAc, and the secondary amine (XIV) was acylated with acetic anhydride in the presence of diisopropyl ethylamine to afford the target acetamide.
| 【1】 Bock, M.G.; Evans, B.E.; Williams, P.D.; et al.; Nonpeptide oxytocin antagonists: Analogs of L-371,257 with improved potency. Bioorg Med Chem Lett 1999, 9, 9, 1311. |
| 【2】 Freidinger, R.M.; Stauffer, K.; Perlow, D.S.; Sparks, M.A.; Williams, P.D.; Bell, I.M. (Merck & Co., Inc.); Tocolytic oxytocin receptor antagonists. GB 2326410; US 6090805 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 40675 | 2,2,2-trifluoroethyl trifluoromethanesulfonate | 6226-25-1 | C3H2F6O3S | 详情 | 详情 | |
| (VI) | 19420 | 1-(4-piperidinyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one | C13H16N2O2 | 详情 | 详情 | |
| (VII) | 13961 | Resacetophenone; 1-(2,4-Dihydroxyphenyl)-1-ethanone | 89-84-9 | C8H8O3 | 详情 | 详情 |
| (VIII) | 18625 | tert-butyl 4-hydroxy-1-piperidinecarboxylate | C10H19NO3 | 详情 | 详情 | |
| (X) | 27110 | tert-butyl 4-[4-acetyl-3-(2,2,2-trifluoroethoxy)phenoxy]-1-piperidinecarboxylate | C20H26F3NO5 | 详情 | 详情 | |
| (XI) | 27111 | tert-butyl 4-[4-(2-methoxy-2-oxoethyl)-3-(2,2,2-trifluoroethoxy)phenoxy]-1-piperidinecarboxylate | C21H28F3NO6 | 详情 | 详情 | |
| (XII) | 27112 | 2-[4-[[1-(tert-butoxycarbonyl)-4-piperidinyl]oxy]-2-(2,2,2-trifluoroethoxy)phenyl]acetic acid | C20H26F3NO6 | 详情 | 详情 | |
| (XIII) | 27113 | tert-butyl 4-[4-(2-oxo-2-[4-[2-oxo-2H-3,1-benzoxazin-1(4H)-yl]-1-piperidinyl]ethyl)-3-(2,2,2-trifluoroethoxy)phenoxy]-1-piperidinecarboxylate | C33H40F3N3O7 | 详情 | 详情 | |
| (XIV) | 27114 | phenyl(1-[2-[4-(4-piperidinyloxy)-2-(2,2,2-trifluoroethoxy)phenyl]acetyl]-4-piperidinyl)formamide | C27H32F3N3O4 | 详情 | 详情 |
合成路线8
该中间体在本合成路线中的序号：(II)4-Hydroxypiperidine (I) was protected as the tert-butyl carbamate (II) upon treatment with (Boc)2O. Subsequent Mitsunobu coupling of (II) with diphenyl disulfide using tributylphosphine and diethyl azodicarboxylate afforded thioether (III). Acid deprotection of the Boc group of (III), followed by nitrosation of the resulting amine (IV) gave N-nitrosopiperidine (V). Further reduction of (V) with LiAlH4 yielded hydrazine (VI). Condensation of (VI) with dichloropurine derivative (VII) produced piperidinyladenosine (VIII). Debenzoylation of the tribenzoate ester (VIII) with methanolic ammonia gave (IX). Then, chlorination at position 5' with concomitant formation of the 2',3' cyclic sulfite (X) by reaction with thionyl chloride and pyridine was followed by sulfite hydrolysis with methanolic ammonia to yield the title compound.
| 【1】 Lau, J.; Judge, M.E.; Sheardown, M.J.; Petersen, H.; Shalmi, M.; Knutsen, L.J.S.; Hansen, A.J.; Thomsen, C.; Weis, J.U.; N-substituted adenosines as novel neuroprotective A1 agonists with diminished hypotensive effects. J Med Chem 1999, 42, 18, 3463. |
| 【2】 Lau, J.; Knutsen, L.J.S. (Novo Nordisk A/S); Chemical cpds., their preparation and use. EP 0719275; JP 1999511436; US 5589467; WO 9507921 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 17473 | diphenyl disulfide; 1-(phenyldisulfanyl)benzene; diphenyldisulfide | 882-33-7 | C12H10S2 | 详情 | 详情 | |
| (I) | 12076 | 4-Piperidinol; 4-Hydroxypiperidine | 5382-16-1 | C5H11NO | 详情 | 详情 |
| (II) | 18625 | tert-butyl 4-hydroxy-1-piperidinecarboxylate | C10H19NO3 | 详情 | 详情 | |
| (III) | 32561 | tert-butyl 4-(phenylsulfanyl)-1-piperidinecarboxylate | C16H23NO2S | 详情 | 详情 | |
| (IV) | 32562 | 4-(phenylsulfanyl)piperidine; phenyl 4-piperidinyl sulfide | C11H15NS | 详情 | 详情 | |
| (V) | 32563 | 1-nitroso-4-piperidinyl phenyl sulfide; 1-nitroso-4-(phenylsulfanyl)piperidine | C11H14N2OS | 详情 | 详情 | |
| (VI) | 32564 | 4-(phenylsulfanyl)-1-piperidinamine; 4-(phenylsulfanyl)-1-piperidinylamine | C11H16N2S | 详情 | 详情 | |
| (VII) | 32565 | (2R,3R,4R,5R)-4-(benzoyloxy)-2-[(benzoyloxy)methyl]-5-(2,6-dichloro-9H-purin-9-yl)tetrahydro-3-furanyl benzoate | C31H22Cl2N4O7 | 详情 | 详情 | |
| (VIII) | 32568 | [(2R,3R,4R,5R)-3,4-bis(benzoyloxy)-5-(2-chloro-6-[[4-(phenylsulfanyl)-1-piperidinyl]amino]-9H-purin-9-yl)tetrahydro-2-furanyl]methyl benzoate | C42H37ClN6O7S | 详情 | 详情 | |
| (IX) | 32566 | (2R,3R,4S,5R)-2-(2-chloro-6-[[4-(phenylsulfanyl)-1-piperidinyl]amino]-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydro-3,4-furandiol | C21H25ClN6O4S | 详情 | 详情 | |
| (X) | 32567 | (3aR,4S,6R,6aR)-4-(chloromethyl)-6-(2-chloro-6-[[4-(phenylsulfanyl)-1-piperidinyl]amino]-9H-purin-9-yl)tetrahydro-2lambda(4)-furo[3,4-d][1,3,2]dioxathiol-2-one | C21H22Cl2N6O4S2 | 详情 | 详情 |
合成路线9
该中间体在本合成路线中的序号：(VI)4-Amino-benzodioxan-1-carboxylic acid (I) is esterified to (II) employing SOCl2 in EtOH. Subsequent chlorination of benzodioxan (II) with N-chlorosuccinimide furnishes (III). The ethyl ester group of (III) is then displaced by hydrazine hydrate to produce the corresponding hydrazide (IV). Cyclization of hydrazide (IV) with phosgene, followed by quenching with benzyl alcohol leads to the oxadiazole derivative (V). This is then coupled with N-Boc-4-piperidinol (VI) under Mitsunobu conditions to yield the piperidinyl oxadiazole (VII). Selective cleavage of the N-Boc protecting group of (VII) by means of trifluoroacetic acid in CH2Cl2 gives rise to piperidine (VIII).
| 【1】 Jegham, S.; Lochead, A.; Galli, F.; Nedelec, A.; Solignac, A.; De Cruz, L. (Sanofi-Synthélabo); 5-Phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3H)-one derivs. for use as 5-HT4 or H3 receptor ligands. EP 0863897; FR 2741069; FR 2741070; JP 2000500125; US 5929089; WO 9717345 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 63653 | 8-amino-2,3-dihydro-1,4-benzodioxine-5-carboxylic acid | C9H9NO4 | 详情 | 详情 | |
| (II) | 63654 | ethyl 8-amino-2,3-dihydro-1,4-benzodioxine-5-carboxylate | C11H13NO4 | 详情 | 详情 | |
| (III) | 63655 | ethyl 8-amino-7-chloro-2,3-dihydro-1,4-benzodioxine-5-carboxylate | C11H12ClNO4 | 详情 | 详情 | |
| (IV) | 63656 | 8-amino-7-chloro-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide | C9H10ClN3O3 | 详情 | 详情 | |
| (V) | 63657 | benzyl 6-chloro-8-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-2,3-dihydro-1,4-benzodioxin-5-ylcarbamate | C18H14ClN3O6 | 详情 | 详情 | |
| (VI) | 18625 | tert-butyl 4-hydroxy-1-piperidinecarboxylate | C10H19NO3 | 详情 | 详情 | |
| (VII) | 63658 | tert-butyl 4-[5-(8-{[(benzyloxy)carbonyl]amino}-7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)-2-oxo-1,3,4-oxadiazol-3(2H)-yl]-1-piperidinecarboxylate | C28H31ClN4O8 | 详情 | 详情 | |
| (VIII) | 63659 | benzyl 6-chloro-8-[5-oxo-4-(4-piperidinyl)-4,5-dihydro-1,3,4-oxadiazol-2-yl]-2,3-dihydro-1,4-benzodioxin-5-ylcarbamate | C23H23ClN4O6 | 详情 | 详情 |
合成路线10
该中间体在本合成路线中的序号：(II)4-Hydroxypiperidine (I) was protected as the N-Boc derivative (II), which was then condensed with 1,2-difluoro-4-nitrobenzene (III) in the presence of potassium tert-butoxide, yielding ether (IV). Reduction of the nitro group of (IV) by transfer hydrogenation, followed by treatment of the resulting aniline (V) with benzyl chloroformate, afforded carbamate (VI). After deprotonation of the carbamate group of (VI) with n-butyllithium, reaction with (R)-glycidyl butyrate (VII) generated the chiral oxazolidinone (VIII). Conversion of (VIII) to mesylate (IX) and subsequent displacement with NaN3 provided azide (X). This was reduced to the corresponding amine, which was acetylated with Ac2O to furnish amide (XI). Cleavage of the Boc protecting group of (XI) with trifluoroacetic acid gave piperidine (XII). This was finally acylated with benzyloxyacetyl chloride (XIII) to provide the title amide.
| 【2】 Boggs, C.M.; et al.; Novel piperidinyloxy-oxazolidinone antimicrobial agents: Effects of position, fluorine substitution, and ring-size on in vitro antimicrobial activity. 220th ACS Natl Meet (Aug 20 2000, Washington DC) 2000, Abst MEDI 98. |
| 【3】 Boggs, C.; Nelson, E.; Weidner-Wells, M.; Hlasta, D. (Ortho-McNeil Pharmaceutical, Inc.); Piperidinyloxy and pyrrolidinyloxyphenyl oxazolidinones as antibacterials. WO 0146164 . |
| 【1】 Hilliard, J.J.; Montenegro, D.A.; Nelson, E.A.; Goldschmidt, R.M.; Boggs, C.M.; Weidner-Wells, M.A.; Wira, E.; Hlasta, D.J.; Melton, J.; Foleno, B.D.; Bush, K.; Piperidinyloxy substituted oxazolidinones as antibacterial agents. Diversification of the N-substituent. 40th Intersci Conf Antimicrob Agents Chemother (Sept 17 2000, Toronto) 2000, Abst F-1828. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 12076 | 4-Piperidinol; 4-Hydroxypiperidine | 5382-16-1 | C5H11NO | 详情 | 详情 |
| (II) | 18625 | tert-butyl 4-hydroxy-1-piperidinecarboxylate | C10H19NO3 | 详情 | 详情 | |
| (III) | 17013 | 1,2-difluoro-4-nitrobenzene; 3,4-Difluoronitrobenzene | 369-34-6 | C6H3F2NO2 | 详情 | 详情 |
| (IV) | 45645 | tert-butyl 4-(2-fluoro-4-nitrophenoxy)-1-piperidinecarboxylate | C16H21FN2O5 | 详情 | 详情 | |
| (V) | 45646 | tert-butyl 4-(4-amino-2-fluorophenoxy)-1-piperidinecarboxylate | 654-01-3 | C16H23FN2O3 | 详情 | 详情 |
| (VI) | 45647 | tert-butyl 4-(4-[[(benzyloxy)carbonyl]amino]-2-fluorophenoxy)-1-piperidinecarboxylate | C24H29FN2O5 | 详情 | 详情 | |
| (VII) | 18385 | (2R)oxiranylmethyl butyrate;(R)-glycidyl butyrate | 60456-26-0 | C7H12O3 | 详情 | 详情 |
| (VIII) | 45648 | tert-butyl 4-[2-fluoro-4-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]phenoxy]-1-piperidinecarboxylate | C20H27FN2O6 | 详情 | 详情 | |
| (IX) | 45649 | tert-butyl 4-[2-fluoro-4-((5R)-5-[[(methylsulfonyl)oxy]methyl]-2-oxo-1,3-oxazolidin-3-yl)phenoxy]-1-piperidinecarboxylate | 22888-70-6 | C21H29FN2O8S | 详情 | 详情 |
| (X) | 45650 | tert-butyl 4-[4-[(5R)-5-(azidomethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-fluorophenoxy]-1-piperidinecarboxylate | C20H26FN5O5 | 详情 | 详情 | |
| (XI) | 45651 | tert-butyl 4-(4-[(5S)-5-[(acetamido)methyl]-2-oxo-1,3-oxazolidin-3-yl]-2-fluorophenoxy)-1-piperidinecarboxylate | C22H30FN3O6 | 详情 | 详情 | |
| (XII) | 45652 | N-([(5S)-3-[3-fluoro-4-(4-piperidinyloxy)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl)acetamide | 2642-63-9 | C17H22FN3O4 | 详情 | 详情 |
| (XIII) | 10493 | 2-(Benzyloxy)acetyl chloride; Benzyloxyacetyl chloride | 19810-31-2 | C9H9ClO2 | 详情 | 详情 |
合成路线11
该中间体在本合成路线中的序号：(II)4-Hydroxypiperidine (I) was protected as the N-Boc derivative (II), which was then condensed with 1,2-difluoro-4-nitrobenzene (III) in the presence of potassium tert-butoxide, yielding ether (IV). Reduction of the nitro group of (IV) by transfer hydrogenation, followed by treatment of the resulting aniline (V) with benzyl chloroformate, afforded carbamate (VI). After deprotonation of the carbamate group of (VI) with n-butyllithium, reaction with (R)-glycidyl butyrate (VII) generated the chiral oxazolidinone (VIII). Conversion of (VIII) to mesylate (IX) and subsequent displacement with NaN3 provided azide (X). This was reduced to the corresponding amine, which was acetylated with Ac2O to furnish amide (XI). Cleavage of the Boc protecting group of (XI) with trifluoroacetic acid, followed by acylation of the resulting piperidine with benzyloxyacetyl chloride, provided amide (XII). Finally, hydrogenolysis of the O-benzyl group of (XII) by transfer hydrogenation in the presence of ammonium formate and Pd/C yielded the title hydroxyacetamide.
| 【1】 Weidner-Wells, M.A.; et al.; Novel piperidinyloxy oxazolidinone antibacterial agents. Diversification of the N-substituent. Bioorg Med Chem 2002, 10, 7, 2345. |
| 【3】 Boggs, C.M.; et al.; Novel piperidinyloxy-oxazolidinone antimicrobial agents: Effects of position, fluorine substitution, and ring-size on in vitro antimicrobial activity. 220th ACS Natl Meet (Aug 20 2000, Washington DC) 2000, Abst MEDI 98. |
| 【4】 Boggs, C.; Nelson, E.; Weidner-Wells, M.; Hlasta, D. (Ortho-McNeil Pharmaceutical, Inc.); Piperidinyloxy and pyrrolidinyloxyphenyl oxazolidinones as antibacterials. WO 0146164 . |
| 【2】 Hilliard, J.J.; Montenegro, D.A.; Nelson, E.A.; Goldschmidt, R.M.; Boggs, C.M.; Weidner-Wells, M.A.; Wira, E.; Hlasta, D.J.; Melton, J.; Foleno, B.D.; Bush, K.; Piperidinyloxy substituted oxazolidinones as antibacterial agents. Diversification of the N-substituent. 40th Intersci Conf Antimicrob Agents Chemother (Sept 17 2000, Toronto) 2000, Abst F-1828. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 12076 | 4-Piperidinol; 4-Hydroxypiperidine | 5382-16-1 | C5H11NO | 详情 | 详情 |
| (II) | 18625 | tert-butyl 4-hydroxy-1-piperidinecarboxylate | C10H19NO3 | 详情 | 详情 | |
| (III) | 17013 | 1,2-difluoro-4-nitrobenzene; 3,4-Difluoronitrobenzene | 369-34-6 | C6H3F2NO2 | 详情 | 详情 |
| (IV) | 45645 | tert-butyl 4-(2-fluoro-4-nitrophenoxy)-1-piperidinecarboxylate | C16H21FN2O5 | 详情 | 详情 | |
| (V) | 45646 | tert-butyl 4-(4-amino-2-fluorophenoxy)-1-piperidinecarboxylate | 654-01-3 | C16H23FN2O3 | 详情 | 详情 |
| (VI) | 45647 | tert-butyl 4-(4-[[(benzyloxy)carbonyl]amino]-2-fluorophenoxy)-1-piperidinecarboxylate | C24H29FN2O5 | 详情 | 详情 | |
| (VII) | 18385 | (2R)oxiranylmethyl butyrate;(R)-glycidyl butyrate | 60456-26-0 | C7H12O3 | 详情 | 详情 |
| (VIII) | 45648 | tert-butyl 4-[2-fluoro-4-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]phenoxy]-1-piperidinecarboxylate | C20H27FN2O6 | 详情 | 详情 | |
| (IX) | 45649 | tert-butyl 4-[2-fluoro-4-((5R)-5-[[(methylsulfonyl)oxy]methyl]-2-oxo-1,3-oxazolidin-3-yl)phenoxy]-1-piperidinecarboxylate | 22888-70-6 | C21H29FN2O8S | 详情 | 详情 |
| (X) | 45650 | tert-butyl 4-[4-[(5R)-5-(azidomethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-fluorophenoxy]-1-piperidinecarboxylate | C20H26FN5O5 | 详情 | 详情 | |
| (XI) | 45651 | tert-butyl 4-(4-[(5S)-5-[(acetamido)methyl]-2-oxo-1,3-oxazolidin-3-yl]-2-fluorophenoxy)-1-piperidinecarboxylate | C22H30FN3O6 | 详情 | 详情 | |
| (XII) | 45653 | benzyl 4-(4-[(5S)-5-[(acetamido)methyl]-2-oxo-1,3-oxazolidin-3-yl]-2-fluorophenoxy)-1-piperidinecarboxylate | C25H28FN3O6 | 详情 | 详情 |
合成路线12
该中间体在本合成路线中的序号：(I)Coupling between N-Boc-4-piperidinol (I) and 4-fluorobenzotrifluoride (II) in the presence of cesium carbonate afforded ether (III). Subsequent acidic cleavage of the Boc protecting group of (III) furnished piperidine (IV) (1). Acylation of piperidine (IV) with 3,4-dimethoxybenzenesulfonyl chloride (V) yielded the corresponding sulfonamide (VI). Regioselective metalation of (VI) by means of tert-butyllithium, followed by quenching with dry carbon dioxide gave rise to the carboxylic acid (VII). This was converted to the corresponding acid chloride (VIII) employing oxalyl chloride, and then condensed with O-tetrahydropyranylhydroxylamine (IX). The resultant tetrahydropyranyl-protected hydroxamate (X) was finally deprotected by treatment with an in situ generated solution of methanolic HCl.
| 【1】 Barta, T.E.; et al.; Selective, orally active MMP inhibitor with an aryl backbone. Bioorg Med Chem Lett 2001, 11, 18, 2481. |
| 【2】 Villamil, C.I.; Becker, D.P.; Bedell, L.J.; Freskos, J.N.; Rao, S.N.; Getman, D.P.; Decrescenzo, G.A.; Mischke, B.V.; Barta, T.E.; McDonald, J.J. (Pharmacia Corp.); Hydroxamic acid derivs. as matrix metalloprotease inhibitors. EP 1177173; WO 0069819 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 18625 | tert-butyl 4-hydroxy-1-piperidinecarboxylate | C10H19NO3 | 详情 | 详情 | |
| (II) | 52131 | 4-Fluorobenzotrifluoride; alpha,alpha-4-Tetrafluorotoluene | 402-44-8 | C7H4F4 | 详情 | 详情 |
| (III) | 52132 | tert-butyl 4-[4-(trifluoromethyl)phenoxy]-1-piperidinecarboxylate | C17H22F3NO3 | 详情 | 详情 | |
| (IV) | 52133 | 4-[4-(trifluoromethyl)phenoxy]piperidine; 4-piperidinyl 4-(trifluoromethyl)phenyl ether | C12H14F3NO | 详情 | 详情 | |
| (V) | 47469 | 3,4-dimethoxybenzenesulfonyl chloride | 23095-31-0 | C8H9ClO4S | 详情 | 详情 |
| (VI) | 52134 | 1-[(3,4-dimethoxyphenyl)sulfonyl]-4-piperidinyl 4-(trifluoromethyl)phenyl ether; 1-[(3,4-dimethoxyphenyl)sulfonyl]-4-[4-(trifluoromethyl)phenoxy]piperidine | C20H22F3NO5S | 详情 | 详情 | |
| (VII) | 52135 | 2,3-dimethoxy-6-([4-[4-(trifluoromethyl)phenoxy]-1-piperidinyl]sulfonyl)benzoic acid | C21H22F3NO7S | 详情 | 详情 | |
| (VIII) | 52136 | 2,3-dimethoxy-6-([4-[4-(trifluoromethyl)phenoxy]-1-piperidinyl]sulfonyl)benzoyl chloride | C21H21ClF3NO6S | 详情 | 详情 | |
| (IX) | 52106 | 2-(aminooxy)tetrahydro-2H-pyran; O-tetrahydro-2H-pyran-2-ylhydroxylamine | C5H11NO2 | 详情 | 详情 | |
| (X) | 52137 | 2,3-dimethoxy-N-(tetrahydro-2H-pyran-2-yloxy)-6-([4-[4-(trifluoromethyl)phenoxy]-1-piperidinyl]sulfonyl)benzamide | C26H31F3N2O8S | 详情 | 详情 |
合成路线13
该中间体在本合成路线中的序号：(I)The (phenylsulfanyl)piperidine (III) was obtained by condensation of N-Boc-4-piperidinol (I) with diphenyl disulfide (II) in the presence of tributylphosphine. Subsequent oxidation of sulfide (III) to the corresponding sulfone (IV) was achieved using oxone® on wet alumina. Deprotection of the N-Boc-piperidine (IV) with HCl afforded piperidine (V), which was finally alkylated with 2-bromo-4'-fluoroacetophenone (VI) to furnish the title N-phenacyl piperidine.
| 【1】 Blurton, P.; Burkamp, F.; Fletcher, S.R.; et al.; 4-(Phenylsulfonyl)piperidines: Novel, selective, and biovailable 5-HT2A receptor antagonists. J Med Chem 2002, 45, 2, 492. |
| 【2】 Macleod, A.M.; Blurton, P.; Fletcher, S.R.; Van Niel, M.B.; Burkamp, F.; Cheng, S.K.-F. (Merck Sharp & Dohme Ltd.); Phenylsulphonyl derivs. as 5-HT receptor ligands. EP 1147083; WO 0043362 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 18625 | tert-butyl 4-hydroxy-1-piperidinecarboxylate | C10H19NO3 | 详情 | 详情 | |
| (II) | 17473 | diphenyl disulfide; 1-(phenyldisulfanyl)benzene; diphenyldisulfide | 882-33-7 | C12H10S2 | 详情 | 详情 |
| (III) | 32561 | tert-butyl 4-(phenylsulfanyl)-1-piperidinecarboxylate | C16H23NO2S | 详情 | 详情 | |
| (IV) | 56311 | tert-butyl 4-(phenylsulfonyl)-1-piperidinecarboxylate | C16H23NO4S | 详情 | 详情 | |
| (V) | 56312 | 4-(phenylsulfonyl)piperidine; phenyl 4-piperidinyl sulfone | C11H15NO2S | 详情 | 详情 | |
| (VI) | 27904 | 2-bromo-1-(4-fluorophenyl)-1-ethanone | 403-29-2 | C8H6BrFO | 详情 | 详情 |